IL-6 signalling biomarkers in hospitalised patients with moderate to severe SARS-CoV-2 infection in a single centre study in SwedenResearch article Published on 2022-11-012022-10-05 Journal: Cytokine [Category] SARS, 바이오마커, [키워드] addition analysed baseline Biomarker Biomarkers C-reactive protein (CRP Care classical correlated correlation COVID-19 COVID-19 disease severity COVID-19 pandemic CRP Cytokine/IL-6 defined demonstrated Epidemiology First wave glycoprotein group groups hospital Hospital admission hospitalised patient IL-6 IL-6 pathway IL-6 receptor immune immune response Infection Inflammation intensive care involved Level longitudinal cohort study marker moderate moderate-severe Mortality not differ pathogen pathway Pathways Patient patients with moderate plasma Potential difference Respiratory Support Result severe COVID-19 severe SARS-CoV-2 sgp130 significantly sIL-6R with COVID-19 [DOI] 10.1016/j.cyto.2022.156020 [Article Type] Research article
Brief Research Report: Serum clara cell 16 kDa protein levels are increased in patients hospitalized for severe SARS-CoV-2 or sepsis infectionArticle Published on 2022-10-132022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 바이오마커, [키워드] age Anti-inflammatory Biomarker case-control study CC16 Cell cell damage chronic pulmonary diseases Concentration disease Diseases ELISA epithelial epithelial cell epithelial cell damage Evidence expressed healthy Increased Infection Infectious disease kDa Lungs Non-pulmonary patients hospitalized patients treated Platelet positively correlated previous study Protein protein level SARS-CoV-2 Sepsis Serum level severe infections severe SARS-CoV-2 significantly increased subjects were measured [DOI] 10.3389/fimmu.2022.1037115 PMC 바로가기
Pembrolizumab in combination with tocilizumab in high-risk hospitalized patients with COVID-19 (COPERNICO): A randomized proof-of-concept phase II studyClinical Trial Published on 2022-10-012022-10-05 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 임상, 진단, [키워드] addition antibody Cell cellular Combination COVID-19 deaths discharge Efficacy and safety elevated faster Hospitalization hospitalized patient hyperinflammation immune dysregulation Infection interleukin 6 receptor lymphocyte males mechanical ventilation median age median time objective Open-label Patient Pembrolizumab Pneumonia Randomized reduced Result SARS-COV-2 infection severe SARS-CoV-2 Standard of care TCZ Tocilizumab Trial with COVID-19 [DOI] 10.1016/j.ijid.2022.08.007 [Article Type] Clinical Trial
Biomarkers extracted by fully automated body composition analysis from chest CT correlate with SARS-CoV-2 outcome severityArticle Published on 2022-09-302022-11-15 Journal: Scientific Reports [Category] SARS, 바이오마커, [키워드] 95% CI adipose adjusted Analysis analyzed approach association automated Biomarker body composition Chest Chest CT complex Computed tomography contribute Course death Deceased defined disease disease severity Endpoint endpoints feature female Female patients genders Infection investigated laboratory parameter male Mann-Whitney-U test marker Mortality Multiple multivariate logistic regression outcome Patient patients promoted remained risk risk stratification SARS-CoV-2 SARS-CoV-2 patients severe SARS-CoV-2 severity small patient cohort statistical significance tissue tissues two-sided Volume [DOI] 10.1038/s41598-022-20419-w PMC 바로가기
Autoantibodies elicited with SARS-CoV-2 infection are linked to alterations in double negative B cellsArticle Published on 2022-09-052022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] Activation alteration antibodies autoantibodies autoantibody Autoimmune disease autoreactive autoreactive antibody B cell B cells BCR Cell changes in characterized CRP described DN1 DN2 DN3 DN3 cells DN4 double negative elevated elicited Frequency functional heterogenous IFNγ IL-1β IL-6 Immunoglobulin increase increase in Infection Inflammation interferon negative precursor pro-inflammatory cytokine reduction in reported SARS-COV-2 infection SARS–CoV–2 secreting cell serum Severe infection severe SARS-CoV-2 Signaling significantly subset systemic inflammation systemic level TNFα viral infection [DOI] 10.3389/fimmu.2022.988125 PMC 바로가기
SARS-CoV-2 mRNA vaccinations fail to elicit humoral and cellular immune responses in patients with multiple sclerosis receiving fingolimodArticle Published on 2022-09-012022-11-15 Journal: Journal of neurology, neurosurgery, and psychiatry [Category] COVID19(2023년), SARS, 진단, [키워드] absence Acetate Alter analysed antagonist approved Autoimmune diseases B cell B cells booster booster vaccinations CD4 Cellular immune response clinical neurology elicit elicited fumarate functional immune response healthy individual homologous humoral humoral immune response IgG Immune cell immunogenic immunology Infection Infectious diseases investigated lack Measures mRNA mRNA vaccination mRNA vaccine multiple sclerosis Neutralising activity Patient patients Peripheral blood prospective cohort study Protective receiving receptor Receptor binding reduced risk SARS-CoV-2 serum severe COVID-19 severe SARS-CoV-2 stability T cell T cell response T cell responses therapy these cell Treatment vaccination Vaccinations vaccine-specific antibodies [DOI] 10.1136/jnnp-2022-329395 PMC 바로가기
COVID-19 in spinal cord injury patients at a veterans administration hospital: A case seriesArticle Published on 2022-09-012022-11-16 Journal: The journal of spinal cord medicine [Category] SARS, 치료기술, [키워드] administration age AIS Asymptomatic BMI case sery Chronic kidney disease chronic obstructive clinical feature Clinical findings co-morbidities Comorbidity Complete Completeness Confirmed COVID-19 infection cough COVID-19 COVID-19 pandemic Critical diagnostic disease course elevated facilitate Fever FIVE General population hospital implementation individual Infection Inflammatory marker Injury Level male Mild Patient predictor Presence presenting severe SARS-CoV-2 severity shown single center spinal cord Spinal cord injury treated Treatment unit veteran viral spread with COVID-19 [DOI] 10.1080/10790268.2020.1871254 PMC 바로가기
SARS-CoV-2 Reinfection Rate and Outcomes in Saudi Arabia: A National Retrospective StudyArticle Published on 2022-09-012022-11-16 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval Analysis B.1.617.2 Care Cohort Comorbidities concern control group COVID-19 vaccine defined demographics disease dose effective first dose Health HIV individual Infection majority Mortality multivariate logistic regression National naturally acquired immunity negative test obesity Odds ratio participant Positive test Pregnancy protective immunity provided Rate Reinfection Result retrospective risk factor SARS-CoV-2 SARS-CoV-2 disease SARS-CoV-2 reinfection SARS-CoV-2 test SARS-CoV-2 variant SARS-CoV-2 variants Saudi Arabia second dose severe disease severe SARS-CoV-2 subject transmissible variant vaccination Vaccine-induced immunity variant variant of concern [DOI] 10.1016/j.ijid.2022.07.025 PMC 바로가기
Consensus of the Liaison-Psychiatry Committee of the Colombian Psychiatric Association on the Diagnosis and Treatment of Delirium in the Context of the COVID-19 PandemicPractice guideline Published on 2022-09-012022-10-05 Journal: Revista Colombiana de Psiquiatría (English ed.) [Category] COVID19(2023년), SARS, 진단, 치료법, 치료제, [키워드] absence alteration Antipsychotics approach Brain Care caused Committee Consensus Context Coronavirus infection cough COVID-19 delirium Diagnosis diagnostic diagnostic techniques and procedures disease disorder Evidence Fever Health hospital Hospitalization increase increase in Infection interactions lung malaise Mental morbidity and mortality New coronavirus organ pandemic Patient pharmacological pharmacological treatment recommendation SARS-CoV-2 severe SARS-CoV-2 Side effect supported the patient Treatment treatments [DOI] 10.1016/j.rcpeng.2020.11.008 [Article Type] Practice guideline
COVID-19 isolation strategies: What have we learnedShort communication Published on 2022-09-012022-10-05 Journal: Travel medicine and infectious disease [Category] SARS, 변종, 진단, 치료기술, [키워드] concern COVID-19 COVID-19 pandemic Evolution highlight infected patients Infection prevention Isolation patients with COVID-19 public health severe SARS-CoV-2 significantly VoC [DOI] 10.1016/j.tmaid.2022.102416 [Article Type] Short communication