Clinical and Virological Features of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants of Concern: A Retrospective Cohort Study Comparing B.1.1.7 (Alpha), B.1.351 (Beta), and B.1.617.2 (Delta)중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 우려 변이의 임상 및 바이러스학적 특징: B.1.1.7(알파), B.1.351(베타) 및 B.1.617.2(베타)를 비교한 후향적 코호트 연구( 델타)Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, [키워드] 95% confidence interval adjusted odds ratio Admission age age and sex analyzed B.1.1.7 B.1.351 B.1.617.2 Beta Chain Reaction clinical clinical outcomes Cohort Comorbidities coronavirus 2 COVID-19 Ct value Ct values cycle threshold death Delta disease severity higher odd higher odds implementation Infection intensive care intensive care unit admission median not seen outcome oxygen Oxygen requirement Patient patients Pneumonia polymerase chain polymerase chain reaction respiratory Retrospective study SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants severity severity of illness Sex significantly lower Singapore study period surveillance data vaccination Vaccination Status variants variants of concern viral shedding VoC VOCs were infected wild-type wild-type strain [DOI] 10.1093/cid/ciab721 PMC 바로가기 [Article Type] Article
Clinical Performance of a Standardized Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Interferon-γ Release Assay for Simple Detection of T-Cell Responses After Infection or Vaccination감염 또는 백신 접종 후 T-세포 반응의 간단한 검출을 위한 표준화된 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 인터페론-γ 방출 분석의 임상 성능Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, 치료기술, [키워드] 19 2 95% confidence interval Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 best Cell cell response Chain Reaction clinical convalescent Convalescent patients coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 CoV COVID COVID-19 dependent on detection disease severity Euroimmun evaluated Follow-up Germany healthy IFN-γ IFN-γ response IFN-γ responses IGRA immune response individual Infection interferon interferon-γ magnitude Mild disease mild infections Neutralizing antibodies neutralizing antibody Patient performance polymerase chain reaction positive Primary infection Prospective Study Quantitative reference standard Release respiratory response reverse transcription Reverse transcription-polymerase chain reaction SARS SARS-CoV-2 SARS-COV-2 infection sensitivity serological serological test Serological tests serology severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe COVID-19 severity severity of illness simple specificity subject subjects T T-cell T-cell Response uninfected vaccination was measured Whole blood with mild disease γ release assay. [DOI] 10.1093/cid/ciab1021 PMC 바로가기 [Article Type] Article
Organ dysfunction and death in patients admitted to hospital with COVID-19 in pandemic waves 1 to 3 in British Columbia, Ontario and Quebec, Canada: a cohort studyObservational Study Published on 2022-04-192022-10-04 Journal: CMAJ open [Category] COVID19(2023년), SARS, 임상, [키워드] 28-day mortality 95% CI 95% confidence interval acute COVID-19 adjusted Admission angiotensin receptor blocker ARB association average baseline characteristics changes in cohort study Community Comorbidity conducted COVID-19 pandemic death demographic characteristics Dexamethasone dysfunction examined excluded hospital Hospital admission IMPROVE in-hospital mortality Invasive mechanical ventilation less Logistic lower mortality management Mortality multicentre Observational cohort study Odds ratio organ support outcome outcomes pandemic Patient Pragmatic readmission Regression model remained renal dysfunction renal replacement therapy RRT severity of illness significantly lower therapy Vasopressor with COVID-19 [DOI] 10.9778/cmajo.20210216 PMC 바로가기 [Article Type] Observational Study
Impact of prior vaccination with Covishield TM and Covaxin® on mortality among symptomatic COVID-19 patients during the second wave of the pandemic in South India during April and May 2021: a cohort study2021년 4월과 5월에 남인도에서 2차 대유행 기간 동안 Covishield TM 및 Covaxin®을 사용한 사전 예방 접종이 증상이 있는 COVID-19 환자의 사망률에 미치는 영향: 코호트 연구Article Published on 2022-03-182022-09-11 Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval Adjusted analysis Admission age Astra Zeneca circulation Cohort cohort study Corona Corona virus COVAXIN® COVID-19 COVID-19 patient COVID-19 patients COVID-19 vaccine COVID-19 vaccines COVISHIELDTM dose doses Emergency use evaluated expressed greater Hospitalization ICU ICU admission Impact impacted indeterminate India intensive care intensive care unit mitigate Mortality NIV non-invasive ventilation Oxford oxygen Oxygen therapy pandemic Patient patients presenting Primary outcome reduced risk risk ratio RT-PCR second wave severity severity of illness south India symptomatic vaccination Vaccine variant were assessed widespread [DOI] 10.1016/j.vaccine.2022.02.023 PMC 바로가기 [Article Type] Article
Secondary infection in COVID-19 critically ill patients: a retrospective single-center evaluationCOVID-19 중환자 환자의 2 차 감염 : 후 향적 단일 센터 평가Observational Study Published on 2022-03-022022-09-10 Journal: BMC Infectious Diseases [Category] MERS, SARS, 임상, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus administration of corticosteroid Admission adult COVID-19 patient aggravate Bacteremia Bacterial infection Bacterial infections Belgium bloodstream infection Bloodstream infections catheter caused cocci Combination coronavirus Corticosteroid Corticosteroids COVID-19 COVID-19 patient COVID-19 patients Critically ill critically ill COVID-19 patients Critically ill patient critically ill patients Culture cultures cumulative Cumulative Dose database develop diabetes Diabetes Mellitus dose eligible for inclusion Gender gram group higher risk highest ICU identify Immunosuppression incidence increased risk Infection intensive care intensive care unit Observational cohort study pathogen Pathogens Patient patients Pneumonia proportion Research Result resulting retrospective retrospective observational cohort study risk risk factor risk of death SARS-CoV-2 secondary bacterial infection Secondary bacterial infections Secondary infection secondary infections secondary pneumonia Sepsis severe acute respiratory syndrome Coronavirus severity severity of illness single-center supplementary material susceptible virus Virus Disease was performed [DOI] 10.1186/s12879-022-07192-x PMC 바로가기 [Article Type] Observational Study
Durable T-cellular and humoral responses in SARS-CoV-2 hospitalized and community patientsSARS-COV-2 입원 및 지역 사회 환자의 내구성 T- 세포 및 체액 반응Clinical Trial Published on 2022-02-222022-09-10 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, [키워드] age analyzed antibody Antibody Response Antibody responses assays Blood blood sample Blood samples boost Clinical data clinical observations collected Community Comorbidity determine diagnosed ELISA Gender Hospitalized Humoral response IFN-γ IgA IgG IgM IL-2 immune response Immunity immunosorbent impacted infected patients Infection interferon interferon-γ interleukin investigated long-term memory memory response microneutralization mononuclear cell mononuclear cells neutralization Neutralizing antibodies neutralizing antibody pandemic Patient patients peripheral Peripheral blood Peripheral blood mononuclear cells prospective cohort Protein pseudotype Re-infection recruited response Result risk RT-PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 virus secreting serum sample serum samples severity severity of illness specific antibodies specific antibody T-cell Response T-cell responses vaccination variant variants of concern virus-specific T-cell response virus-specific T-cell responses viruses [DOI] 10.1371/journal.pone.0261979 PMC 바로가기 [Article Type] Clinical Trial
A new SARS-CoV-2 variant with high lethality poorly detected by RT-PCR on nasopharyngeal samples: an observational study비인두 샘플에 대한 RT-PCR로 잘 검출되지 않는 높은 치사율을 지닌 새로운 SARS-CoV-2 변종: 관찰 연구Observational Study Published on 2022-02-012022-09-11 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 변종, 임상, 치료기술, [키워드] 28-day mortality 95%CI acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed anti-SARS-CoV-2 Characteristics chest CT scan clinical collected coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus infections Coronavirus infections/epidemiology Coronavirus infections/virology COVID-19 COVID-19 case COVID-19 cases Cox model enrolled feature hospital Inclusion inclusion criteria Inpatient interquartile range involved IQR Lineage Lower respiratory tract lower respiratory tract samples multivariable nasopharyngeal nasopharyngeal sample Nasopharyngeal samples new SARS-CoV-2 nosocomial Older outbreak outcome Patient positive radiological respiratory sample RT-PCR RT-PCR test RT-PCR tests SARS-CoV-2 SARS-CoV-2 RT-PCR SARS-CoV-2 variants Sequencing Seroconversion severe disease severity of illness severity of illness index Symptom the WHO variant Virological Virology VoC WGS whole-genome sequencing [DOI] 10.1016/j.cmi.2021.09.035 PMC 바로가기 [Article Type] Observational Study
Modelling upper respiratory viral load dynamics of SARS-CoV-2SARS-CoV-2의 상부 호흡기 바이러스 부하 역학 모델링Research Article Published on 2022-01-132022-09-12 Journal: BMC Medicine [Category] SARS, 진단, [키워드] age antibody can be used collected correlated strongly COVID-19 explained Factor Host host response identify immune response immune responses Immune-mediated individuals late phase magnitude Neutralising Antibodies Pathogenesis produced regression analysis relationship SARS-CoV-2 severity severity of illness Sex subject subjects subsequent supplementary material symptom onset therapeutic Transmissibility Transmission Treatment upper respiratory upper respiratory tract URT variable Variation Viral load virus [DOI] 10.1186/s12916-021-02220-0 PMC 바로가기 [Article Type] Research Article
Persistence of live virus in critically ill patients infected with SARS-COV-2: a prospective observational studySARS-COV-2에 감염된 중환자에서 살아있는 바이러스의 지속성: 전향적 관찰 연구Observational Study Published on 2022-01-042022-09-11 Journal: Critical Care [Category] SARS, 임상, 치료기술, [키워드] 95% CI AUC best Chain Reaction COVID-19 COVID-19 pneumonia Critically ill patient Culture cycle cycle threshold detect determine diagnosis of COVID-19 ICU admission ICU patient ICU Patients infection control infectiousness initial intensive care unit interquartile range lab lack Level 4 Live virus mechanical ventilation median nasopharyngeal nasopharyngeal sample Nasopharyngeal samples nasopharyngeal sampling non-infectious observational study Patient patients with COVID-19 PCR test performed polymerase chain polymerase chain reaction positive positive rate positive RT-PCR Positive test predict Prospective prospective observational study repeated Result reverse transcriptase Reverse transcriptase polymerase chain reaction RT-PCR severity of illness specificity Test threshold Vero Cell Vero cells Viral viral culture Viral RNA were measured with COVID-19 [DOI] 10.1186/s13054-021-03884-z PMC 바로가기 [Article Type] Observational Study
Visual classification of three computed tomography lung patterns to predict prognosis of COVID-19: a retrospective studyCovid-19의 예후를 예측하기위한 3 가지 컴퓨터 단층 촬영 폐 패턴의 시각적 분류 : 후 향적 연구Research Published on 2022-01-032022-09-01 Journal: BMC Pulmonary Medicine [Category] 바이오마커, 진단, 치료제, [키워드] administration Admission Analysis Antigen association body temperature C-reactive protein Clinical data Clinical practice clinical variable collected Compromised Computed tomography coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients D-dimer death decrease demographic and clinical variables Diagnosis diagnostic evaluate evaluated Favipiravir Health care Hounsfield unit intensive care intensive care unit intervals Intubated intubation Lactate lactate dehydrogenase lung Lungs lymphocyte Lymphocyte count neutrophil neutrophil count outcome Patient patients hospitalized patients with COVID-19 Pneumonia predict Prognosis Prognostic value Protein Quantitative Radiographic reading respiratory Respiratory function Result resulting retrospective cohort study Retrospective study severity severity of COVID-19 severity of illness significantly single-center steroid suggested tested tracheal tracheal intubation United States utility Ventilation Visual Volume was performed with COVID-19 [DOI] 10.1186/s12890-021-01813-y PMC 바로가기 [Article Type] Research