Two genetic variants in the SRD5A2 gene are found to be associated with sex differences in the disease characteristics of patients with chronic hepatitis B virus infectionarticle Published on 2023-10-032024-09-05 Journal: Biol Sex Differ [Category] update2024, [키워드] Chronic HBV infection Hepatitis B virus Sex difference sex hormone Sex hormone receptor Single nucleotide polymorphism SRD5A2 [DOI] 10.1186/s13293-023-00553-4 PMC 바로가기 [Article Type] article
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection by Intranasal or Intratesticular Route Induces Testicular Damage비강 또는 고환 경로에 의한 중증 급성 호흡기 증후군 코로나바이러스 2(SARS-CoV-2) 감염은 고환 손상을 유발합니다Article Published on 2022-08-242022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 신종인플루엔자, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Apoptosis asymmetric Awareness caused Cell change changes convalescent coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 damage death decrease degeneration delta variant demonstrated Depletion Disruption epididymal epithelial cells expressing hamster hamsters hemorrhage histopathological hypogonadism immune complex immunological change induce Infection Inflammation Influenza Influenza virus injection interstitial cell interstitial cells intranasal investigated Leydig cell Leydig cells lung tissues men Necrosis nucleocapsid omicron Pathogenesis Pneumonia prevented protein expression reduction in respiratory respiratory tract infection route SARS-CoV-2 SARS-CoV-2 nucleocapsid seminiferous Sertoli serum severe acute respiratory syndrome Coronavirus Sex sex hormone Sperm sperm count spermatogenesis spermatogenic cell spermatozoa subfertility subsequent testes testicle testicle. Testicular Testosterone vaccination variant Viral load viral loads Virological virus inoculum weight while wild-type SARS-CoV-2 worsening [DOI] 10.1093/cid/ciac142 PMC 바로가기 [Article Type] Article
Effects of Cordyceps militaris fermentation products on reproductive development in juvenile male mice Research Published on 2022-08-122022-10-05 Journal: Scientific Reports [Category] 바이오마커, [키워드] activity analyzed basic Concentration control group Cordyceps militaris Effect evaluated Extracellular group groups male mice parameters polysaccharide promote promoted reproductive seminiferous sex hormone significantly significantly higher significantly increased [DOI] 10.1038/s41598-022-18066-2 [Article Type] Research
Epigenetic mechanisms regulate sex-specific bias in disease manifestations후성 유전적 메커니즘은 질병 발현에서 성별에 따른 편향을 조절합니다Review Published on 2022-08-012022-09-11 Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] 유전자 메커니즘, [키워드] affecting Anatomy Autoimmune disorders Cancer change chromosome Clinical outcome clinical study COVID-19 COVID-19 infection differential expression disease disease manifestation disease onset Diseases Effect Epigenetic epigenetic modification epigenetics exhibit explained expression fibrosis Genes Genetic Genetic and epigenetic changes Hormones immune response immune responses immune system implicated inactivation infections input involved Liver fibrosis mechanism Neuropsychiatric Neuropsychiatric diseases progression recent regulate Respiratory disease respiratory diseases response to therapy responsible Sex Sex bias Sex chromosome sex hormone Sex hormones susceptibility therapeutic targets therapy underlying disease X chromosome X-inactivation X-linked X-linked gene X-linked genes. [DOI] 10.1007/s00109-022-02227-x PMC 바로가기 [Article Type] Review
Effects of acute severe acute respiratory syndrome coronavirus 2 infection on male hormone profile, ACE2 and TMPRSS2 expression, and potential for transmission of severe acute respiratory syndrome coronavirus 2 in semen of Asian men급성 중증 급성 호흡기 증후군 코로나바이러스 2 감염이 남성 호르몬 프로필, ACE2 및 TMPRSS2 발현에 미치는 영향, 아시아 남성의 정액에서 중증 급성 호흡기 증후군 코로나바이러스 2 전파 가능성Article Published on 2022-02-012022-09-11 Journal: F&S science [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 ACE2 and TMPRSS2 expression ACE2 expression Acute COVID-19 infection acute phase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute SARS-CoV-2 infection affected age androgen Asian binding changes in clinical clinical study Cohort Contact coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 COVID-19 infection detect detectable diagnosis of SARS-CoV-2 diagnostic Effect expressed expression expression of SARS-CoV-2 follicle-stimulating hormone Human Infection Laboratory laboratory-confirmed Luteinizing Hormone male male hormone male hormone profile masturbation men Mild molecular morning Nasopharyngeal swab normal range outcome potential for transmission profile recruited RNA SARS-CoV-2 SARS-CoV-2 expression SARS-COV-2 infection SARS-CoV-2 RNA Semen severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Sex sex hormone Singapore Symptom Testosterone TMPRSS2 TMPRSS2 expression undetectable university was collected [DOI] 10.1016/j.xfss.2021.11.003 PMC 바로가기 [Article Type] Article
Association Between Sex Hormone Levels and Clinical Outcomes in Patients With COVID-19 Admitted to Hospital: An Observational, Retrospective, Cohort StudyObservational Study Published on 2022-01-272022-10-04 Journal: Frontiers in Immunology [Category] 임상, [키워드] age ARDS association both sexes clinical cohort study confounders COVID-19 COVID-19 patients death estradiol hormone Hospitalized in-hospital mortality Italy Level male males median age Older outcome Patient Probability progesterone Protective Regression model reported retrospective severe COVID-19 severity Sex sex hormone Sex hormones stratified by sex STROBE survivor Testosterone understanding with COVID-19 [DOI] 10.3389/fimmu.2022.834851 PMC 바로가기 [Article Type] Observational Study
Immuno-Endocrinology of COVID-19: The Key Role of Sex HormonesCOVID-19의 면역 내분비학: 성 호르몬의 주요 역할Review Published on 2021-12-022022-09-11 Journal: Frontiers in Endocrinology [Category] SARS, 유전자 메커니즘, [키워드] Adaptive immune response androgen Clinical studies clinical study coronavirus coronavirus 2019 disease COVID-19 COVID-19 pathogenesis COVID-19 severity Cytopathic effect disease severity element Estrogen Evidence Factor Factors fatality Gender Gene regulation hormone hyper-inflammatory response identify immune response immune responses immuno-endocrinology include Infection Injury involved mechanism optimization Pathogenesis personalised regulated Regulation role SARS-CoV2 severity Sex sex hormone Sex hormones susceptibility target targets therapeutic intervention tissue injury tissue specific Treatment outcome Trial [DOI] 10.3389/fendo.2021.726696 PMC 바로가기 [Article Type] Review
Semen parameters in men recovered from COVID-19: a systematic review and meta-analysisReview Published on 2021-12-022022-10-29 Journal: Middle East Fertility Society Journal [Category] COVID-19, [키워드] 95% CI Affect age article Concentration confidence interval consequence Control COVID-19 database disease eligibility eligible evaluated females heterogeneity high risk Hormones infertility less Luteinizing Hormone male Male sex mean difference mechanism men Meta-analysis novel beta-coronavirus observational studies parameter participant reported SARS-CoV-2 Semen serum Seven sex hormone Sex hormones Standard deviation subject suffered supplementary material systematic review Volume was performed were assessed [DOI] 10.1186/s43043-021-00089-w PMC 바로가기 [Article Type] Review
Predicting respiratory failure in patients infected by SARS-CoV-2 by admission sex-specific biomarkers입원 성별 바이오 마커에 의해 SARS-COV-2에 의해 감염된 환자의 호흡기 부전 예측Research Published on 2021-11-222022-08-31 Journal: Biology of Sex Differences [Category] MERS, SARS, 바이오마커, [키워드] 17β-estradiol ACE2 acute respiratory distress acute respiratory distress syndrome Admission affecting analysed Angiotensin1-7 ARDS association Biomarker Biomarkers choice circulating COVID-19 COVID-19 patient COVID-19 severity Definition Deterioration discharged estradiol Estrogen female female patient Female patients females Gender hospital Hospitalization identify lymphocyte Lymphocytes male males neutrophil neutrophil count Occurrence outcome Patient plasma plasma biomarker Plasma level Plasma levels predict predicted Predictive progression respiratory respiratory distress Respiratory failure Result SARS-CoV-2 severe respiratory failure severity Sex Sex difference sex hormone Sex hormones specific biomarker syndrome Testosterone were measured worsening [DOI] 10.1186/s13293-021-00407-x PMC 바로가기 [Article Type] Research
Why Females Do Better: The X Chromosomal TLR7 Gene-Dose Effect in COVID-19여성이 더 잘하는 이유: 코로나19에서 X 염색체 TLR7 유전자 용량 효과Immunology Published on 2021-11-112022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 치료법, [키워드] age biallelic caused concerning contribute COVID-19 COVID-19 pandemic COVID-19 treatment dendritic cells Effect expression Factor female gene-dose effect Hypothesis ICU IFN IFN pathway IFN response Immune cell immune cells Immunopathogenesis inactivation Infection interferon investigated Male sex modulation Mortality Pattern recognition pattern recognition receptor Pattern recognition receptors plasmacytoid dendritic cell plasmacytoid dendritic cells Protective responsible SARS-CoV-2 severe COVID-19 severity Sex difference sex differences sex hormone Sex hormones ssRNA TLR TLR7 TLR7 gene Toll-like receptor Treatment type 1 interferon Viral viral infections X chromosome X chromosome inactivation escape [DOI] 10.3389/fimmu.2021.756262 PMC 바로가기 [Article Type] Immunology