A CTB-SARS-CoV-2-ACE-2 RBD Mucosal Vaccine Protects Against Coronavirus InfectionArticle Published on 2023-12-182024-09-05 Journal: Vaccines [Category] update2024, [키워드] angiotensin converting enzyme (ACE-2) receptor binding domain (RBD) Beta coronaviruses cholera toxin B subunit COVID-19 Mucosal immunization protein subunit vaccine SARS-CoV-2 SIgA Virus neutralization [DOI] 10.3390/vaccines11121865 PMC 바로가기 [Article Type] Article
Mucosal antibody responses to SARS-CoV-2 booster vaccination and breakthrough infectionObservation Published on 2023-12-012024-09-05 Journal: mBio [Category] update2024, [키워드] booster vaccination Breakthrough infection mRNA vaccine Saliva SARS-CoV-2 SIgA spike [DOI] 10.1128/mbio.02280-23 PMC 바로가기 [Article Type] Observation
Safety and immunogenicity of heterologous boosting with orally administered aerosolized bivalent adenovirus type-5 vectored COVID-19 vaccine and B.1.1.529 variant adenovirus type-5 vectored COVID-19 vaccine in adults 18 years and older: a randomized, double blinded, parallel controlled trialEmerging and Re-Emerging Coronaviruses Published on 2023-11-062024-09-05 Journal: Emerging Microbes & Infections [Category] update2024, [키워드] Bivalent adenovirus type-5 vectored COVID-19 vaccine inhalation mucosal immunity Safety SIgA [DOI] 10.1080/22221751.2023.2281355 PMC 바로가기 [Article Type] Emerging and Re-Emerging Coronaviruses
SARS-CoV-2 vaccination induces mucosal antibody responses in previously infected individualsArticle Published on 2022-09-012022-11-15 Journal: Nature Communications [Category] SARS, 진단, [키워드] acute respiratory syndrome antibody Antibody Response Antigen coronavirus coronavirus disease COVID-19 Critical humans impacted individual induce infected individual mRNA vaccination mucosal Patient pre-existing immunity Prevent respiratory infection response Saliva SARS-CoV-2 SARS-CoV-2 vaccination secretory IgA serum SIgA vaccination [DOI] 10.1038/s41467-022-32389-8 PMC 바로가기
Survival of Vaccine-Induced Human Milk SARS-CoV-2 IgG, IgA and SIgA Immunoglobulins across Simulated Human Infant Gastrointestinal Digestion인간 유아 위장 소화를 통한 백신 유도 모유 SARS-CoV-2 IgG, IgA 및 SIgA 면역글로불린의 생존Article Published on 2022-08-172022-09-12 Journal: Nutrients [Category] SARS, 진단, [키워드] adenovirus-based antibody Breastfeeding breastmilk COVID-19 COVID-19 pandemic Degradation digestion dose evaluated Evidence Gastrointestinal GI Tract help Human human milk IgA IgA antibody IgG Immunoglobulin immunoglobulins in vitro Inconclusive Infant information intestinal lactating milk mother mRNA-based vaccine natural infection passive immunity persistence Pfizer/BioNTech produced PROTECT protective role protocol recent reduced reduction SARS-CoV-2 SARS-CoV-2 IgG secretory IgA SIgA the SARS-CoV-2 virus the spike protein the vaccine transfer vaccination Vaccine women [DOI] 10.3390/nu14163368 PMC 바로가기 [Article Type] Article
Mucosal immunity: The missing link in comprehending SARS-CoV-2 infection and transmissionArticle Published on 2022-08-172022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] accumulating acquisition acute respiratory disease Administered aerosol antibody Antibody Response asymptomatic infection cause Community consequence Contact COVID COVID-19 demonstrated disease droplet explain helping humans immune system Immunoglobulin immunoglobulin A induce Infection initial intranasally limit lung mice Mild mucosal mucosal immune mucosal immunity mucosal secretion naïve subjects nasal fluid nasal passage Prevent protective immune response recall repeated response resulting Saliva SARS-CoV-2 SARS-COV-2 infection secretion secretory IgA SIgA Spread subjects suppress tonsil Transmission upper respiratory upper respiratory tract Vaccine virus while [DOI] 10.3389/fimmu.2022.957107 PMC 바로가기
Effects of Vaccination Against Influenza, Pertussis, and COVID-19 on Human Milk Antibodies: Current Evidence and Implications for Health Equity인플루엔자, 백일해 및 COVID-19에 대한 예방 접종이 모유 항체에 미치는 영향: 건강 형평성에 대한 현재 증거 및 시사점Review Published on 2022-07-122022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 백일해, 진단, [키워드] addition Administered Against anti-SARS-CoV-2 IgG antibody benefit COVID COVID - 19 COVID-19 COVID-19 vaccine current Effect Human human milk IgA response IgG IgG response IgM Immunity immunization IMPROVE induce infant health Influenza lactation milk mRNA vaccine mucosal pathogen specific pertussis pertussis vaccine Pregnancy PROTECT public health Research respiratory illnesses secretory IgA shown SIgA Support the SARS-CoV-2 virus vaccination [DOI] 10.3389/fimmu.2022.910383 PMC 바로가기 [Article Type] Review
Inhalable dry powder mRNA vaccines based on extracellular vesiclesResearch article Published on 2022-07-112022-10-05 Journal: Matter [Category] 비임상, [키워드] Bioavailability Bronchiole carriers circumvent COVID-19 death disease distribution dry powder inhalation elicited exhibited Exosome Exosomes extracellular vesicle Extracellular vesicles functional greater IgG illness Immunoglobulin Inhaled limitation limitations Liposome lung mRNA mRNA vaccine NHPs nonhuman primate Protein remained respiratory Respiratory Coronavirus response rodent SARS-CoV-2 secretory IgA SIgA Spike protein stability Therapeutics Vaccine [DOI] 10.1016/j.matt.2022.06.012 [Article Type] Research article
Bacteria-enabled oral delivery of a replicon-based mRNA vaccine candidate protects against ancestral and delta variant SARS-CoV-2레플리콘 기반 mRNA 백신 후보의 박테리아 지원 경구 전달은 조상 및 델타 변이형 SARS-CoV-2로부터 보호Article Published on 2022-05-042022-09-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 alphaviruses antibody antigenic diversity B.1.617.2 Bacteria Cellular immune response cellular immune responses clade contributed contributing to Coronavirus-2 COVID-19 cross-protective domain Efficacy epitope Epitopes Evolution feasible forest gene delivery hamster hamsters heptad repeat immune responses immunization immunized immunized mice Immunoglobulin lung Lungs mass vaccination membrane protein mRNA mRNA vaccine mucosal mucosal vaccine NAbs nasal Nasal cavity Neutralizing antibodies neutralizing antibody non-structural protein nsp13 offer oral Oral Immunization oral route Pneumonia principle PROTECT provide RBD Receptor binding domain recorded replicon-based respiratory Salmonella Salmonella-mediated SARS-CoV-2 secretory IgA SIgA the vaccine vaccination Vaccine vaccine efficacy variant variants Viral viral replication virus [DOI] 10.1016/j.ymthe.2022.01.042 PMC 바로가기 [Article Type] Article
Immune Responses in Pregnant Sows Induced by Recombinant Lactobacillus johnsonii Expressing the COE Protein of Porcine Epidemic Diarrhea Virus Provide Protection for Piglets against PEDV InfectionArticle Published on 2021-12-212022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Lactobacillus johnsonii (L. johnsonii) activate administration antibody Antigen cause Cell cellular immune responses COE COE antigen dendritic cell develop effective epidemic diarrhea epitope evaluated expressing humoral IgA IgG antibody IgM antibody immune protection immune responses immunomodulatory effect in vitro induced Infection Infectious disease intestinal lactobacillus maturation mucosal Neutralizing Oral Immunization Oral vaccine PEDV pregnant pregnant sow protection Protein recombinant response secretory immunoglobulin A serum IgG SIgA triggered vaccination Vaccine viral spike protein virus [DOI] 10.3390/v14010007 PMC 바로가기 [Article Type] Article