Benzomorphan and non-benzomorphan agonists differentially alter sigma-1 receptor quaternary structure, as does types of cellular stressOriginal Article Published on 2024-01-092024-09-05 Journal: Cellular and Molecular Life Sciences [Category] update2024, [키워드] Endoplasmic reticulum MAM Mitochondria neurodegenerative disorders sigma-1 receptor [DOI] 10.1007/s00018-023-05023-z PMC 바로가기 [Article Type] Original Article
Targeting Sigma-1 Receptor: A Promising Strategy in the Treatment of Parkinson’s DiseaseReview Published on 2023-05-312024-09-05 Journal: Neurochemical research [Category] update2024, [키워드] neuroprotection Parkinson’s disease S1R agonists sigma-1 receptor [DOI] 10.1007/s11064-023-03960-6 PMC 바로가기 [Article Type] Review
Sigma-1 receptor and seizuresArticle Published on 2023-05-012024-09-05 Journal: Pharmacological Research [Category] update2024, [키워드] Multidimensional drug target Seizure-related comorbidities Seizures sigma-1 receptor Sigma-1 receptor knockout Sigma-1 receptor ligands [DOI] 10.1016/j.phrs.2023.106771 PMC 바로가기 [Article Type] Article
Inhibition of SARS-CoV-2 infection in human iPSC-derived cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoarchitecture and beatingBiochemistry Published on 2021-12-202022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] 48 hours abrogate Affect arrhythmia cardiomyocyte cause Cell cell death chaperone condition consequence COVID COVID-19 patients described detrimental effect disrupt downregulating dysfunction expressed expression Frequency infect inhibition investigated IPSC myocarditis number of infected prevented pro-inflammatory cytokine Protective effects receptor reduced reducing reported SARS-CoV-2 SARS-COV-2 infection sigma-1 receptor survival therapeutic potential therapeutic target triggered viral particle [DOI] 10.7717/peerj.12595 PMC 바로가기 [Article Type] Biochemistry
Anaesthesia drugs, SARS-CoV-2, and the sigma-1 receptor: a complex affair. Comment on Br J Anaesth 2021; 127: e32-4마취 약물, SARS-COV-2 및 시그마 -1 수용체 : 복잡한 일.Br J Anaesth 2021에 대한 의견;127 : E32-4Comment Published on 2021-12-012022-08-31 Journal: British journal of anaesthesia [Category] SARS, 치료제, [키워드] Abstract anaesthetic drugs autophagy Comment complex COVID-19 drugs opioid receptor SARS-CoV-2 sigma-1 receptor [DOI] 10.1016/j.bja.2021.09.008 PMC 바로가기 [Article Type] Comment
Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected CellsArticle Published on 2021-11-202022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] antiviral activity antiviral therapeutics cellular Characteristics Combination complex Contact COVID-19 drug Drug discovery effective Host human cells impacted inhibit inhibiting Interaction investigated Ligand molecular docking pathway property receptor Receptor binding Replication representing SA4503 SARS-CoV-2 SARS-CoV-2 genome SARS-COV-2 infection SARS-CoV-2 mutation SARS-CoV-2 protein sigma sigma-1 receptor Specific therapeutic Toxicity Treatment treatment strategy variants of concern virus virus infection [DOI] 10.3390/pathogens10111514 PMC 바로가기 [Article Type] Article
Repurposing of CNS drugs to treat COVID-19 infection: targeting the sigma-1 receptorCOVID-19 감염 치료를 위한 CNS 약물의 용도 변경: 시그마-1 수용체 표적화Review Published on 2021-03-012022-08-31 Journal: European archives of psychiatry and clinical neuro [Category] 신약개발, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adult outpatient adult outpatients antidepressant approved arketamine article candidate caused cells Central nervous system Clinical deterioration clinical trial CNS coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cutamesine demonstrated donepezil drug Endoplasmic reticulum fluvoxamine global pandemic high affinity ifenprodil indicate infected individuals infected with SARS-CoV-2 knockdown knockout market Novel coronavirus novel coronavirus disease Prevent Prophylactic protein-protein interaction receptor reductions in Replication repurposing respiratory robust SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2-infected individual SARS-CoV-2-infected individuals SARS-CoV-2-infected patients severe acute respiratory syndrome Coronavirus sigma sigma-1 receptor SIGMAR1 status therapeutic drug therapeutic target treat Treatment Viral viral spread [DOI] 10.1007/s00406-020-01231-x PMC 바로가기 [Article Type] Review
Identification of antiviral antihistamines for COVID-19 repurposingCOVID-19 용도 변경을 위한 항바이러스성 항히스타민제 식별Article Published on 2021-01-292022-08-31 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 신약개발, 유전자 메커니즘, 치료제, [키워드] ACE2 adjuvant therapy age angiotensin angiotensin converting enzyme Angiotensin converting enzyme-2 Antihistamine Antihistamines Antiviral antiviral activity Antiviral effect antiviral effects approved drug approved drugs azelastine benefit candidate clinical Clinical studies COVID-19 COVID-19 patients diphenhydramine disease docking Effectiveness Electronic health record Electronic health records enzyme greater Histamine hydroxyzine identification identify IMPROVE in vitro in vitro activity incidence Intervention ligands mechanism outcome Prevent receptor Receptor binding reduced Repurposed drug Repurposed drugs repurposing safety profile SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 positivity severe COVID-19 sigma sigma-1 receptor subject tested therapy Treatment Usage [DOI] 10.1016/j.bbrc.2020.11.095 PMC 바로가기 [Article Type] Article
Repurposing Sigma-1 Receptor Ligands for COVID-19 Therapy?Pharmacology Published on 2020-11-092022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] activate acute respiratory syndrome adaptive Anti-viral Antiviral Antiviral compound antiviral drug approach approaches approved drug benefit cause chaperone clinical development clinical trials coronavirus Course COVID-19 COVID-19 pandemic COVID-19 patients CoVs Drug repurposing drugs Endoplasmic reticulum ER membranes ER stress expected facilitate Health host cell host cell response host protein identify in vitro Infection infections interact Interaction interfere Intervention Ligand mechanism Medicine membrane-bound modulation occur pathway patients potential mechanism Prevent professional protective immune response Proteins provide receptor reduce regulate Repurposed drugs repurposing SARS-CoV-2 SARS-CoV-2 protein sigma-1 receptor Stress targeting the disease therapeutic therapy treat unique upstream viral replication [DOI] 10.3389/fphar.2020.582310 PMC 바로가기 [Article Type] Pharmacology