Clinical data mining reveals Gancao-Banxia as a potential herbal pair against moderate COVID-19 by dual binding to IL-6/STAT3임상 데이터 마이닝은 IL-6/STAT3에 대한 이중 결합에 의해 중간 정도의 CovID-19에 대한 잠재적 인 허브 쌍으로 간카오-밴 내증을 밝혀냅니다.Article Published on 2022-06-012022-08-31 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, 치료제, [키워드] activator Analysis applied association benzyl binding Bioinformatic Chinese Chinese medicines (CMs) clinical clinical records Commission coniferin coronavirus disease Coronavirus disease 2019 COVID-19 Critical cytokine Cytokine storm Data mining Defense demonstrated dual FIVE Frequency Gancao-Banxia Gene ontology genomes group highest IL-6 immune response immune responses indicated Inflammatory response ingredient inhibit interleukin interleukin-6 Interleukin-6 (IL-6) KEGG Kyoto licochalcone a Medicine Moderate COVID-19 moderate COVID-19 patients molecular docking multisite network network pharmacology Pathways patients piperazine potential mechanisms PPI protein-protein interaction provided quercetin quinone Radix reveal SARS-CoV-2 signal Signal transducer and activator of transcription Signal transducer and activator of transcription 3 (STAT3). signaling pathways STAT3 Support target targets the cytokine storm therapeutic efficacy therapy Transcription Viral were used [DOI] 10.1016/j.compbiomed.2022.105457 PMC 바로가기 [Article Type] Article
Anti-Inflammatory Treatment of COVID-19 Pneumonia With Tofacitinib Alone or in Combination With Dexamethasone is Safe and Possibly Superior to Dexamethasone as a Single Agent in a Predominantly African American CohortResearch article Published on 2021-06-012022-10-05 Journal: Mayo Clinic Proceedings: Innovations, Quality & Outcomes [Category] 치료법, [키워드] addition adjusted adjusted odds ratio African American age agent Anti-inflammatory therapy AORadjusted odds ratio benefit C-reactive protein center clinical parameter Computed tomography coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 diagnosis COVID-19coronavirus disease 2019 CRPC-reactive protein CTComputed Tomography death Delta Delta Regional Medical Center Dexamethasone discharged DRMCDelta Regional Medical Center Eligible patients group hospital Hospitalization Hospitalized hospitalized patient ILInterleukin immunomodulator in-hospital mortality inhibitor interleukin JAKJanus kinase janus Janus kinase objective Odds ratio OROdds Ratio Other Patient PCRpolymerase chain reaction Pneumonia polymerase chain reaction Primary outcome proportion reduction in Regional Result retrospective Signal transducer and activator of transcription single-center STATSignal transducer and activator of transcription Superior survival Tofacitinib Transcription treated Treatment treatment regimen [DOI] 10.1016/j.mayocpiqo.2021.03.007 [Article Type] Research article
Therapeutic targets and signaling mechanisms of vitamin C activity against sepsis: a bioinformatics study패혈증에 대한 비타민 C 활성의 치료 표적 및 신호 메커니즘: 생물정보학 연구Article Published on 2021-05-202022-09-11 Journal: Briefings in Bioinformatics [Category] SARS, 유전자 메커니즘, [키워드] accumulating addition assays benefit bioinformatics Bioinformatics analysis Biological functions biological processe Clinical practice conducted coronavirus coronavirus disease coronavirus disease-2019 Effect EGFR epidermal epidermal growth factor evidence of functional growth factor hub genes immune immune dysfunction implicated Inflammation involved JUN Kyoto life-threatening MAPK1 mechanism mitogen mitogen-activated protein kinase molecular mechanism molecular mechanisms network pharmacology Pathways Pneumonia Predictive Protein receptor Sepsis shown Signal transducer and activator of transcription Signaling signaling pathway signaling pathways STAT3 suppression target targets treat Treatment Vitamin C [DOI] 10.1093/bib/bbaa079 PMC 바로가기 [Article Type] Article
Type I Interferon (IFN)-Regulated Activation of Canonical and Non-Canonical Signaling PathwaysImmunology Published on 2020-11-232022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] accumulating approach biological activity canonical cells clinical implication consequence COVID-19 Critical cytoplasm element event Evidence group of disease IFN-stimulated gene IFNs immune response interferon ISG ISGs JAK/STAT mammalian target of rapamycin MAP kinase signaling mRNA translation nucleus outcomes Pathways positive Protein SARS-CoV-2 Signal transducer and activator of transcription Signaling signaling cascade signaling pathways Transcription transcriptional activation treat Type Type I IFN type I interferon [DOI] 10.3389/fimmu.2020.606456 PMC 바로가기 [Article Type] Immunology
Clinical Pharmacology of Janus Kinase Inhibitors in Inflammatory Bowel DiseaseSupplement Article Published on 2020-08-112024-09-04 Journal: Journal of Crohn's and Colitis [Category] 대상포진, [키워드] inflammatory bowel diseases Janus kinase inhibitors Janus kinases Signal transducer and activator of transcription [DOI] 10.1093/ecco-jcc/jjaa014 PMC 바로가기 [Article Type] Supplement Article
Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn’s diseaseReview Published on 2020-07-282024-09-04 Journal: World journal of gastroenterology [Category] 대상포진, [키워드] Crohn’s disease Inflammatory bowel disease JAK/STAT inhibition JAK/STAT pathway Janus kinase Signal transducer and activator of transcription Tofacitinib ulcerative colitis [DOI] 10.3748/wjg.v26.i28.4055 PMC 바로가기 [Article Type] Review