significant component

[키워드] aberrant immune response aberrant macrophage and plasma-cell responses acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition anatomic sites arteritis Autopsy cellular distribution cellular resolution characterized coronavirus coronavirus disease Corticosteroid Corticosteroids COVID-19 death deleterious inflammation determine direct reaction effort evidence of excessive reactive plasmacytosis fatal COVID-19 highlight Histologic evidence immune response immune responses Immune-mediated independent immunopathologic process Inflammation influx iron iron-laden macrophages life-threatening coronavirus disease lung lymphoid tissues Macrophage macrophage/monocyte-lineage cell macrophage/monocyte-lineage cells macrophages mapped measurement monocyte/myeloid-rich vasculitis Multiple Multiple aberrant immune responses multiplex immunofluorescence Multiplex PCR novel immunopathologic mechanism novel immunopathologic mechanisms occur occurred organ dysfunction organ injury organ-specific inflammatory response organ-specific inflammatory responses organotropism pathogen tolerance postmortem examinations primary mechanism promote Protein pulmonary immune response pulmonary parenchyma quantified rationale reduce mortality respiratory response responses reticuloendothelial reticuloendothelial system SARS-CoV-2 SARS-CoV-2 RNA Sequencing severe acute respiratory syndrome Coronavirus severe disease significant component stereotyped abnormal reticuloendothelial responses therapeutically target tissue Tissue-specific immunopathology tissues Vasculitis Viral viral presence viral S virus virus-independent immunopathologic process
[DOI] 10.1164/rccm.202008-3265OC PMC 바로가기 [Article Type] Original Articles