Favipiravir, lopinavir-ritonavir, or combination therapy (FLARE): A randomised, double-blind, 2 × 2 factorial placebo-controlled trial of early antiviral therapy in COVID-19Article Published on 2022-10-192022-11-15 Journal: PLoS Medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] 95% CI Administered administration Adverse affected analysed antiviral therapy Antiviral treatment ARMS baseline changed Combination combination therapy concentrations conducted coronavirus 2 COVID-19 COVID-19 pandemic Day Dose escalation doses double-blind double-blind trial drug level effective Efficacy evaluate the effect event Favipiravir healthy Interaction Lopinavir-ritonavir measure monotherapy Odds ratio Outpatient participant Participants Phase 2 Placebo placebo-controlled placebo-controlled trial placebos plasma primary analysis Primary outcome provided randomised recruited reduced respiratory SARS-CoV-2 SARS-CoV-2 viral load significant interaction significantly study population symptom onset the mean trajectory Treatment undetectable United Kingdom Viral load virus [DOI] 10.1371/journal.pmed.1004120 PMC 바로가기
Tracking the incidence and risk factors for SARS-CoV-2 infection using historical maternal booking serum samplesArticle Published on 2022-09-022022-11-15 Journal: PLoS ONE [Category] SARS, 치료기술, [키워드] Antenatal anti-RBD antibody binding domain community transmission Critical death Deprivation determine Effect Estimated Evidence groups hospitalisation incidence London NHS Outbreaks pandemic peaked Prevalence quantified reflect resource risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor serum sample serum samples significant interaction tested the SARS-CoV-2 virus Transmission dynamics [DOI] 10.1371/journal.pone.0273966 PMC 바로가기
Hair cortisol as a risk marker for increased depressive symptoms among older adults during the COVID-19 pandemicCOVID-19 대유행 기간 동안 노인들 사이에서 증가된 우울 증상에 대한 위험 마커로서의 헤어 코르티솔Article Published on 2022-09-012022-09-11 Journal: Psychoneuroendocrinology [Category] 바이오마커, 유전자 메커니즘, [키워드] 95% CI adjusted Ageing applied association center clinically collected cortisol covariate COVID-19 COVID-19 pandemic Depression depressive depressive symptom Depressive symptoms Determining Effect elevated environmental stress epidemiological studies Evidence evidence of exposure to female finding hair help identify individual investigated likelihood logistic regression model longitudinal longitudinal study marker mental health Modification no evidence of Older Older adults pandemic Pathways phenotype predicted psychological health risk risk markers scale Sex significant interaction significantly Stress susceptibility Wave were assessed [DOI] 10.1016/j.psyneuen.2022.105847 PMC 바로가기 [Article Type] Article
Global slowness and increased intra-individual variability are key features of attentional deficits and cognitive fluctuations in post COVID-19 patients Research Published on 2022-07-302022-10-05 Journal: Scientific Reports [Category] 임상, 치료기술, 치료법, [키워드] Analysis ANOVA assessment assessments Attention cognitive collected components Control controls cortical COVID-19 COVID-19 neurological symptoms COVID-19 patient disorder distribution enrolled executive explain fatigue feature fluctuation hallmark healthy volunteer impairment intra-individual measure mechanism Montreal motor Neurological involvement Patient patients reaction resting RTS significant interaction significantly higher sustained Symptom syndrome time to define Variability [DOI] 10.1038/s41598-022-17463-x [Article Type] Research
Association between smoking and COVID-19 severity: A multicentre retrospective observational studyObservational Study Published on 2022-07-222022-10-04 Journal: Medicine [Category] COVID19(2023년), SARS, 임상, [키워드] Accuracy active smoking Algorithms Analysis Clinical severity Comorbidities complex coronavirus disease COVID-19 COVID-19 severity decrease diabetes enrolled hospital hypertension Interaction Jiangsu multicentre non-severe group number of comorbidity Patient patients patients with COVID-19 predictor variable progression proportion Prospective Study random remained retrospective risk factor risk of COVID-19 selective severe COVID-19 severe disease severe group severity significant interaction significantly significantly higher smoking smoking status Univariate analysis were used [DOI] 10.1097/MD.0000000000029438 PMC 바로가기 [Article Type] Observational Study
Predictive medicinal metabolites from Momordica dioica against comorbidity related proteins of SARS-CoV-2 infectionsSARS-CoV-2 감염의 동반 질환 관련 단백질에 대한 Momordica dioica의 예측 의약 대사 산물Article Published on 2022-07-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE-2 ADME angiotensin angiotensin converting enzyme antidiabetic Antiviral binding binding affinities Blood brain barrier cardiovascular disease catechin comorbid comorbid condition comorbid conditions Comorbidity Compound correlated DDP4 diabetes dipeptidyl peptidase docking score DPP4 drugs enzyme exhibited Favipiravir flavonoid flavonoids gastrointestinal tract hederagenin Human Hydroxychloroquine immune immunomodulatory activities in silico in vitro investigated involved kidney ligands metabolite molecular molecular docking Momordica Momordica dioica oleanolic acid plant predicted protease Proteases Protein quercetin RdRP receptor reflect Remdesivir reported RNA-dependent RNA polymerase Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 main protease significant interaction Spike protein the SARS-CoV-2 therapeutic viral entry viral proteases [DOI] 10.1080/07391102.2020.1868340 PMC 바로가기 [Article Type] Article
Vascular alterations among male elite athletes recovering from SARS-CoV-2 infection Research Published on 2022-05-232022-10-05 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, [키워드] absence Affect age alteration Analysis ANOVA athletic Biomarker Biomarkers calculated cardiovascular system central blood pressure COVID-19 cross-over Effect evaluated examined Follow-up healthy impairment indicate Interaction interaction effect investigated male normalized observation performed positive recovering from COVID-19 repeated measure repeated-measures ANOVA reported SARS-CoV-2 SARS-COV-2 infection severe COVID-19 Significant significant interaction Symptoms tested transfer Vascular Vascular function [DOI] 10.1038/s41598-022-12734-z [Article Type] Research
Effectiveness of COVID-19 vaccines against SARS-CoV-2 variants of concern: a systematic review and meta-analysis우려되는 SARS-CoV-2 변종에 대한 COVID-19 백신의 효과: 체계적인 검토 및 메타 분석Meta-Analysis Published on 2022-05-232022-09-11 Journal: BMC Medicine [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval Ad26 Ad26.COV2.S Alpha Alpha variant Analysis BBIBP-CorV Beta BNT162b2 booster vaccination calculated case-control studies case-control study ChAdOx1 CIs Cohort studies cohort study conducted controlled trials CoronaVac COV2.S COVID-19 COVID-19 vaccine COVID-19 vaccines CVnCoV defined Delta delta variant Delta variants effective Effectiveness estimate evaluated Evidence Gamma Interaction Meta-analysis moderate mRNA mRNA vaccine mRNA vaccines mRNA-1273 NVX-CoV2373 omicron Omicron variants Participants random-effect Random-effects meta-analysis Randomized controlled trial RCT RCTs SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants SCB-2019 searched significant interaction systematic review vaccination Vaccine vaccine effectiveness variants variants of concern VoC [DOI] 10.1186/s12916-022-02397-y PMC 바로가기 [Article Type] Meta-Analysis
Pulmonary embolism severity and in-hospital mortality: An international comparative study between COVID-19 and non-COVID patientsResearch article Published on 2022-04-012022-10-05 Journal: European journal of internal medicine [Category] 바이오마커, [키워드] Analysis association clinical picture COVID COVID case COVID patient Covid patients COVID-19 evaluated French in both group In-hospital In-hospital death in-hospital mortality Interaction International less lobar Mortality objective outcome Patient patients patients with PE PCR-confirmed performed PESI Pulmonary embolism Result risk Risk factors severity significant interaction significantly Spanish subsegmental ventricular dysfunction [DOI] 10.1016/j.ejim.2022.01.035 [Article Type] Research article
Enhancing Physical Activity and Psychological Well-Being in College Students during COVID-19 through WeActive and WeMindful InterventionsRandomized Controlled Trial Published on 2022-03-312022-10-04 Journal: International Journal of Environmental Research an [Category] 임상, [키워드] activity aerobic All participant assigned college COVID-19 Effect effective eight Enhancing Follow-up group intensity Intervention moderate participant physical physical activity Qualtrics Randomly Resilience resilience score Resistance training scale significant interaction significantly increased student university students web-based intervention. [DOI] 10.3390/ijerph19074144 PMC 바로가기 [Article Type] Randomized Controlled Trial