Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial Research Published on 2022-07-212022-10-05 Journal: Nature Medicine [Category] 변종, 임상, 치료제, [키워드] 95% confidence interval Administered administration adverse event approval benefit biopsy cells characteristic clinical disease doses Efficacy Fever Glioblastoma herpes simplex initial investigator-initiated Japan leukopenia lymphocyte lymphocytopenia magnetic resonance imaging nausea occurred Patient patients phase 2 trial prespecified endpoint primary endpoint radiation therapy registry safety profile Secondary endpoints single-arm trial survival survival rate the median therapy Trial virus vomiting [DOI] 10.1038/s41591-022-01897-x [Article Type] Research
Onasemnogene abeparvovec for presymptomatic infants with three copies of SMN2 at risk for spinal muscular atrophy: the Phase III SPR1NT trial Research Published on 2022-06-172022-10-05 Journal: Nature Medicine [Category] 변종, 유전자 메커니즘, 임상, 진단, [키워드] biallelic children Deletion develop developmental effective Efficacy and safety Infant Intervention investigated investigator MOST multicenter muscular Mutation phase presymptomatic required Respiratory Support risk Serious Adverse Event single-arm trial SMN1 SMN2 Support survived symptom onset treated Trial urgency Ventilation WHO [DOI] 10.1038/s41591-022-01867-3 [Article Type] Research
Combination anti-HIV antibodies provide sustained virological suppression Research Published on 2022-06-012022-10-05 Journal: Nature [Category] 바이오마커, 임상, 치료제, [키워드] Administered antibody Antiretroviral therapy antiviral agent baseline clinical trial clinically Combination combination therapy Complete develop double-blind effective enrolled Guidance half-lives HIV HIV infection Human immunodeficiency virus individual inhibit initiated neutralizing monoclonal antibodies neutralizing monoclonal antibody offer Open-label participant Placebo placebo-controlled trial plasma provided Randomized Serious Adverse Event single-arm trial study participant Study participants sustained therapy transfer Treatment Viraemia virological suppression virus with HIV [DOI] 10.1038/s41586-022-04797-9 [Article Type] Research
Resource and infrastructure challenges on the RESIST-2 Trial: an implementation study of drug resistance genotype-based algorithmic ART switches in HIV-2-infected adults in Senegal저항 2 시험의 자원 및 인프라 과제 : 세네갈의 HIV-2에 감염된 성인의 약물 저항성 유전자형 기반 알고리즘 아트 스위치의 구현 연구Clinical Trial Published on 2021-12-182022-09-01 Journal: Trials [Category] SARS, 임상, 진단, [키워드] AIDS Algorithm antiretroviral drugs Antiretroviral therapy ART Blood can be used conducted Controlled trial counseling COVID-19 COVID-19 pandemic defined demonstrated dolutegravir drug resistance drug resistance testing enrolled Evidence evidence of Follow-up funding genotypes genotypic help HIV treatment HIV-2 implementation Implementation study inhibitor lack mutations National no evidence of nucleoside outcome participant Participants Patient per-protocol point-of-care prevented problem problems protease Protease inhibitor receiving regimen Result reverse transcriptase RLS Seattle single-arm trial suppressed switching transcriptase Treatment Trial Trial registration Viral Viral load Viral suppression VL testing was performed were assessed [DOI] 10.1186/s13063-021-05902-5 PMC 바로가기 [Article Type] Clinical Trial
Clinical efficacy and security of glycyrrhizic acid preparation in the treatment of anti-SARS-CoV-2 drug-induced liver injury: a protocol of systematic review and meta-analysis항 -SARS-COV-2 약물-유도 간 손상의 치료에서 혈당산 제제의 임상 효능 및 보안 : 체계적인 검토 및 메타 분석의 프로토콜Article Published on 2021-07-092022-08-31 Journal: BMJ Open [Category] meta-analysis, SARS, [키워드] acute pneumonia analyses Analysis anti-SARS-CoV-2 antiviral effects assessment China Chinese clinical clinical variable Cochrane Handbook collected conducted confidence COVID-19 COVID-19 research cumulative defined development Drug-induced liver injury Efficacy English Ethical approval Ethics Evidence Final geographical region glycyrrhizic acid Grey literature guidelines Handbook Healthcare professional healthcare professionals heterogeneity Infectious disease Infectious diseases infectious diseases & infestations Infrastructure item journal language limitation liver Liver injury Meta-analysis meta-regression OVID Patient patients patients with COVID-19 peer-reviewed performed Pneumonia PROSPERO protocol protocols protocols & public health Quality Randomised controlled trials registration number Reporting required researcher Retrospective study review Risk of bias Scientific community screened security selected single-arm trial study population Subgroup analyses systematic review systematic reviews Treatment Web of Science [DOI] 10.1136/bmjopen-2021-051484 PMC 바로가기 [Article Type] Article
Efficacy and tolerability of bevacizumab in patients with severe Covid-19중증 코로나19 환자에서 베바시주맙의 효능 및 내약성Clinical Trial Published on 2021-02-052022-08-13 Journal: Nature Communications [Category] MERS, 임상, 진단, 치료법, 치료제, [키워드] ambient anti-vascular Anti-vascular endothelial growth factor bevacizumab bevacizumab plus standard care body temperature changes Chest computed tomography chest imaging China Clinical efficacy clinical trial comparable Computed tomography conducted control group Controlled trial controls COVID-19 patient COVID-19 patients discharged Drug development endothelial Fever fraction growth factor IMPROVE improving oxygenation inspiration Italy lesion areas/ratio mmHg NCT04275414 oxygen oxygen pressure oxygen saturation oxygen-support status Oxygenation PaO partial arterial oxygen pressure Patient patients Pneumonia pulmonary pathological Randomized controlled trial recruited reduction relative respiratory rate SARS-CoV-2 severe COVID-19 shortening oxygen-support duration shown Significant single-arm single-arm trial standard care Tolerability Treatment Vascular vascular changes VEGF viral infection X-ray [DOI] 10.1038/s41467-021-21085-8 PMC 바로가기 [Article Type] Clinical Trial