single nucleotide – Communicable Diseases Research

Rapid detection of SARS-CoV-2 variants of concern by single nucleotide polymorphism genotyping using TaqMan assays

Article

Published on 2022-12-012022-11-15
Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 변종, 치료기술,

[키워드] 95% CI Accuracy acute respiratory syndrome approach B.1.1.7 B.1.526 clinical setting Concordance coronavirus coronavirus disease 19 Coronavirus disease 19 (COVID-19) E484K evaluated genotyping mutations N501Y nasopharyngeal Negative predictive value New York City nonsynonymous patient population polymorphism positive positive sample predicted ranged Rapid Real-time reverse-transcription PCR residual RT-qPCR SARS-CoV-2 SARS-CoV-2 testing SARS-CoV-2 variant sensitivity Sequencing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significantly lower single nucleotide specificity Spike protein submitted subset TaqMan TaqMan assay Thermofisher variant variants variants of concern were used WGS whole genome
[DOI] 10.1016/j.diagmicrobio.2022.115789 PMC 바로가기

Evidence of co-infections during Delta and Omicron SARS-CoV-2 variants co-circulation through prospective screening and sequencing

Article

Published on 2022-11-012022-11-15
Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제,

[키워드] Analysis chimeric circulation Co-infection collected COVID-19 Delta Delta and Omicron VOC Epidemic epidemiologically evidence of France generate Genetic Health Infection K417N L452R Mutation nasopharyngeal sample omicron Pandemics pathogenic patients PCR assay polymorphism primer sets profile Recombination recombination event Respiratory samples S-gene mutation Sample SARS-CoV-2 SARS-CoV-2 co-infection SARS-CoV-2 genome SARS-CoV-2 variant screened sequence Sequencing single nucleotide Single nucleotide polymorphism Single nucleotide polymorphism screening SNP SNPs submitted Surveillance variant virus VoC was performed WGS whole genome Whole genome sequencing
[DOI] 10.1016/j.cmi.2022.06.030 PMC 바로가기

From oncoproteins to spike proteins: the evaluation of intramolecular stability using hydropathic force field

Article

Published on 2022-11-012022-11-16
Journal: Journal of computer-aided molecular design [Category] 유전자 메커니즘,

Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 Spike

Article

Published on 2022-10-262022-11-15
Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종, 진단,

[키워드] acid acute respiratory syndrome addition addressed Amino acid amino acid substitution antigenic Antisera Care caused characterized coronavirus COVID-19 death demonstrated expressing expression level fitness FIVE GISAID globe greater Health highlight host immunity identifying Immune escape immune evasion immunological profile initiative Intervention L452 less lineages maintain mutant Mutation mutational studies Naturally neutralization pandemic phenotypic position promote pseudovirus retrieved SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant selected sensitivity sequence single nucleotide spike Spike protein Substitution T cell Transmissibility variants of concern viral evolution viral fitness viral infectivity virus VoC
[DOI] 10.1128/jvi.01162-22 PMC 바로가기

Reverse Transcription-Loop-Mediated Isothermal Amplification-CRISPR-Cas13a Technology as a Promising Diagnostic Tool for SARS-CoV-2

Article

Published on 2022-10-262022-11-16
Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료기술,

[키워드] acute respiratory syndrome caused change clinical samples coronavirus coronavirus disease COVID-19 CRISPR-Ca CRISPR-Cas CRISPR-Cas13 cycle threshold deaths develop Diagnosis diagnostic Diagnostic method early diagnosis effort exhibit highlighting isothermal isothermal amplification maintain Molecular diagnosis nasopharyngeal sample Negative predictive value New coronavirus NPV pandemic performed persist Positive predictive value PPV Prevalence protocol reaction required researcher RNA extraction RNA molecules RT-LAMP SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus sensitivity Sensitivity and specificity single nucleotide single-stranded specificity technology viral loads
[DOI] 10.1128/spectrum.02398-22 PMC 바로가기

Association of ACE2 Gene Variants with the Severity of COVID-19 Disease-A Prospective Observational Study

Article

Published on 2022-10-022022-11-16
Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 변종,

Early Detection of SARS-CoV-2 Omicron BA.4 and BA.5 in German Wastewater

Article

Published on 2022-08-252022-11-15
Journal: Viruses [Category] SARS, 변종, 치료기술, 치료제,

Gene Variants Related to Cardiovascular and Pulmonary Diseases May Correlate with Severe Outcome of COVID-19

심혈관 및 폐 질환과 관련된 유전자 변이가 COVID-19의 심각한 결과와 관련될 수 있음

Article

Published on 2022-08-042022-09-11
Journal: International Journal of Molecular Sciences [Category] 변종,

Multidrug-resistant OXA-48/CTX-M-15 Klebsiella pneumoniae cluster in a COVID-19 intensive care unit: salient lessons for infection prevention and control during the COVID-19 pandemic

Research article

Published on 2022-08-012022-10-05
Journal: The Journal of hospital infection [Category] 변종,

[키워드] Appropriate Carbapenemase-producing Enterobacterales Cluster Contact COVID-19 COVID-19 pandemic COVID-19 patients CPE Critical disease doffing donning Escalation finding healthcare healthcare worker hygiene ICU ICUs infection control Infection prevention Infection prevention and control intensive care intensive care patient intensive care unit Intervention isolate Klebsiella pneumoniae measure multidrug-resistant Multidrug-resistant organisms Mutation organism Organisms outbreak outer membrane pathogen Patient patients Personal protective equipment Phylogenetic polymorphism Precaution Prevent Prolonged protocol reduced SARS-CoV-2 screening swab Sequencing Sequencing analysis single nucleotide specimen Surveillance Transmission transmission of SARS-CoV-2 ward with COVID-19
[DOI] 10.1016/j.jhin.2022.05.001 [Article Type] Research article

Are Pain Polymorphisms Associated with the Risk and Phenotype of Post-COVID Pain in Previously Hospitalized COVID-19 Survivors?

이전에 입원한 COVID-19 생존자의 통증 다형성이 COVID-19 이후 통증의 위험 및 표현형과 관련이 있습니까?

Article

Published on 2022-07-262022-09-11
Journal: Genes [Category] 변종,

[키워드] All participants Anxiety association BDNF carried clinical feature Clinical features cognitive collected COMT COVID-19 de novo depressive distribution distributions Features female Gender Genotype Hospitalization hospitalized COVID-19 HTR1B involved kinesiophobia long-COVID Musculoskeletal neuropathic neuropathic pain no differences no effect not significantly different nucleotide OPRM1 Pain participant Participants participated phenotypic feature phenotypic features polymerase chain reaction polymerase chain reactions polymorphism Post-COVID Psychological risk rs4680 rs6265 selected sensitization single nucleotide Single nucleotide polymorphism sleep quality SNP SNPs survivor Survivors Symptom Symptoms variable variant were assessed
[DOI] 10.3390/genes13081336 PMC 바로가기 [Article Type] Article