Sirtuin 1
[용어속성] Term
Senescent cells as promising targets to tackle age-related diseases
Review article
[키워드] also known as Akt
also known as E3 ubiquitin-protein ligase Mdm2
group 2A
group 2D
(p)Rb(phosphorylated) retinoblastoma protein
(phosphorylated) retinoblastoma protein
AKTProtein kinase B
An activating Natural Killer (NK) cell receptor
Anti-apoptotic B-cell lymphoma
Ataxia telangiectasia and Rad3-related protein
Ataxia-telangiectasia mutated
ATMAtaxia-telangiectasia mutated
ATRAtaxia telangiectasia and Rad3-related protein
BclAnti-apoptotic B-cell lymphoma
Biomarker
Cell
cell cycle arrest
cellular senescence
Characteristics
Checkpoint kinase 2
Chk2Checkpoint kinase 2
clearance
contribute
DDRDNA damage response
disease
DNA damage response
DNA segments with chromatin alterations reinforcing senescence
DNA-SACRSDNA segments with chromatin alterations reinforcing senescence
ERKextracellular signal-regulated kinases
examined
extracellular signal-regulated kinases
Forkhead box protein O4
FOXO4Forkhead box protein O4
genotoxic
hallmark
health system
heat shock protein
highlight
HSP90Heat shock protein
IkBInhibitor of nuclear factor kappa B
IKKIκB kinase
ILInterleukin
IMMP2LInner mitochondrial membrane peptidase subunit 2
immune system
Inhibitor of nuclear factor kappa B
Inner mitochondrial membrane peptidase subunit 2
interleukin
Interleukin-1 receptor-associated kinase 1
investigated
IRAK1Interleukin-1 receptor-associated kinase 1
IκB kinase
Mammalian target of rapamycin complex 1/2
MAPKmitogen-activated protein kinase
MDM2Mouse double minute 2 homolog
mechanism
mitogen-activated protein kinase
Mitogen-activated protein kinase-activated protein kinase 2
MK2Mitogen-activated protein kinase-activated protein kinase 2
Mouse double minute 2 homolog
mTORC1/2Mammalian target of rapamycin complex 1/2
NADPHNicotinamide adenine dinucleotide phosphate
NEMONF-kappa-B essential modulator
NF-kappa-B essential modulator
NF-kBNuclear factor – κB
Nicotinamide adenine dinucleotide phosphate
NKG2AAn activating Natural Killer (NK) cell receptor
NKG2DAn activating Natural Killer (NK) cell receptor
Nuclear factor – κB
occur
OISOncogene-induced senescence
Oncogene-induced senescence
organism
phosphatase and tensin homolog
Phosphoinositide 3-kinases
physiological
PI3KPhosphoinositide 3-kinases
PICSPTEN-loss–induced cellular senescence
Potential
potential therapeutic target
Premature
Protein kinase B
PTEN-loss–induced cellular senescence
PTENphosphatase and tensin homolog
reactive oxygen species
replicative
Research
ROSreactive oxygen species
SA-β-GalSenescence-associated beta-galactosidase
SAHFSenescence-associated heterochromatin foci
SAMSenescence-accelerated mice
SASPsenescence-associated secretory phenotype
Senescence-accelerated mice
Senescence-associated beta-galactosidase
Senescence-associated heterochromatin foci
senescence-associated secretory phenotype
senescent cell
SIRT1Sirtuin 1
Sirtuin 1
Stressor
target
therapeutic approaches
therapy
Therapy induced senescence
TISTherapy induced senescence
wound healing
[DOI] 10.1016/j.arr.2020.101251 [Article Type] Review article
[DOI] 10.1016/j.arr.2020.101251 [Article Type] Review article