Immune Reactions of Vector Insects to Parasites and PathogensReview Published on 2024-03-122024-09-05 Journal: Microorganisms [Category] update2024, [키워드] Aedes Anopheles antimicrobial peptides Arboviruses blackflies Chagas disease Culex Eicosanoids encapsulation Filariasis Fleas immune priming insect vector immunity Leishmaniasis Lice malaria melanisation mosquitoes onchocerciasis pathogen recognition phagocytosis Rhodnius Sandflies signaling pathways sleeping sickness tsetse flies [DOI] 10.3390/microorganisms12030568 PMC 바로가기 [Article Type] Review
Identifying regions for enhanced control of gambiense sleeping sickness in the Democratic Republic of Congo Research Published on 2022-03-182022-10-05 Journal: Nature Communications [Category] 진단, [키워드] African trypanosomiasis Blanket Coverage disease Endemic Health identifying Impact likelihood predicted reduction in Region required sleeping sickness Transmission utilised vector control while zone [DOI] 10.1038/s41467-022-29192-w [Article Type] Research
Cost-effectiveness of sleeping sickness elimination campaigns in five settings of the Democratic Republic of Congo Research Published on 2022-02-252022-10-05 Journal: Nature Communications [Category] 진단, [키워드] African trypanosomiasis Algorithm average Coverage driven by FIVE fixed Health include outcome persist Probability reported sleeping sickness the disease Transmission vector control [DOI] 10.1038/s41467-022-28598-w [Article Type] Research
Predicted Impact of COVID-19 on Neglected Tropical Disease Programs and the Opportunity for Innovation방치된 열대성 질병 프로그램 및 혁신 기회에 대한 COVID-19의 예측된 영향Viewpoints Published on 2021-04-152022-09-10 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 치료기술, [키워드] accelerate activity coronavirus COVID-19 COVID-19 pandemic disease Diseases Drug administration faster hindrance Impact infections Innovation Intervention lymphatic filariasis Mathematical modelling mitigate modeling Neglected neglected tropical diseases new infections NTD NTDs onchocerciasis opportunity Program resurgence risk Schistosomiasis sleeping sickness STH trachoma tropical tropical disease visceral leishmaniasis [DOI] 10.1093/cid/ciaa933 PMC 바로가기 [Article Type] Viewpoints
Improved Access to Diagnostics for Rhodesian Sleeping Sickness around a Conservation Area in Malawi Results in Earlier Detection of Cases and Reduced MortalityArticle Published on 2020-12-012023-06-22 Journal: Journal of Epidemiology and Global Health [Category] 조류인플루엔자, [키워드] Diagnosis diagnostic Human African trypanosomiasis Malawi rhodesian rhodesiense. sleeping sickness [DOI] 10.2991/jegh.k.200321.001 PMC 바로가기
Identification of a novel base J binding protein complex involved in RNA polymerase II transcription termination in trypanosomes트리파노솜에서 RNA 중합효소 II 전사 종결에 관여하는 새로운 염기 J 결합 단백질 복합체의 확인Research Article Published on 2020-02-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Ablation addition African sleeping sickness Analysis base binding binding domain cause co-IP complex dephosphorylation derepression described DNA downstream genes Epigenetic eukaryotes expand expressed expression Factors gene cluster gene clusters Gene Expression Genome homolog Host Human humans identification identify immune evasion Interaction involved lead leads Leishmania mammalian mass spectrometry mechanism Modification mutant mutants organism Organisms organized phosphatase promoter Protein protein complex Protozoa Reciprocal recruitment regulate regulated Regulatory residue RNA RNA Polymerase II RNA-Seq RNAi RT-PCR shown significantly silent sleeping sickness specific proteins sucrose surface Surface glycoprotein termination thymine Transcription transcription start sites Trypanosoma Trypanosoma brucei Trypanosome upstream variant Variant Surface Glycoprotein Wdr82 yeast [DOI] 10.1371/journal.pgen.1008390 PMC 바로가기 [Article Type] Research Article
Transcriptional and genomic parallels between the monoxenous parasite Herpetomonas muscarum and Leishmania일산화 기생충 Herpetomonas muscarum과 Leishmania 사이의 전사 및 게놈 유사점Research Article Published on 2019-11-112022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] biting flies causative agents conserved Culture Diptera disease Drosophila melanogaster early stage early stages event Gene regulation Genome genomic highlighting Host hosts Human identify in vitro infect Infection infections insect Insects Interaction Leishmania Leishmania major Leishmaniasis less mammal mammalian mammals monoxenous parasites MOST Neglected NTDs parasite parasites Regulation reported Sand similarity sleeping sickness Transcriptome Transmission transmitted Tropical Diseases Trypanosome turn vector [DOI] 10.1371/journal.pgen.1008452 PMC 바로가기 [Article Type] Research Article
Anti-Trypanosomal and Antimalarial Properties of Tetralone Derivatives and Structurally Related Benzocycloalkanones테트라론 유도체 및 구조적으로 관련된 벤조사이클로알카논의 항트리파노소말 및 항말라리아 특성Communication Published on 2019-05-242024-08-11 Journal: Medicina [Category] 말라리아, [키워드] Anti-malarial anti-trypanosomal benzocycloalkanone hit optimization malaria sleeping sickness tetralone [DOI] 10.3390/medicina55050206 PMC 바로가기 [Article Type] Communication
Discovery of 2-(1H-imidazo-2-yl)piperazines as a new class of potent and non-cytotoxic inhibitors of Trypanosoma brucei growth in vitroArticle Published on 2018-12-152024-08-28 Journal: Bioorganic & Medicinal Chemistry Letters [Category] 말라리아, [키워드] 2-(1H-imidazo-2-yl)piperazines antiparasitic Human African trypanosomiasis (HAT) sleeping sickness Trypanosoma brucei.
Impact of mass chemotherapy in domestic livestock for control of zoonotic T. b. rhodesiense human African trypanosomiasis in Eastern UgandaArticle Published on 2017-01-012023-06-21 Journal: Acta tropica [Category] 조류인플루엔자, [키워드] Animal African trypanosomiais (AAT) animal reservoir burden DALYs Endemic Human African trypanosomiasis (HAT) outbreak reservoir sleeping sickness T. b. gambiense T. b. gambiense HAT (gHAT) T. b. rhodesiense T. b. rhodesiense HAT (rHAT) Trypanocide Uganda zoonosis [DOI] 10.1016/j.actatropica.2016.08.022