Fluorogenic RNA-Based Biosensors of Small Molecules: Current Developments, Uses, and PerspectivesReview Published on 2024-08-012024-09-05 Journal: Biosensors [Category] update2024, [키워드] flap Fluorescent reporters fluorogenic RNA-based biosensors light-up aptamer molecular imaging RNA Selection small molecule structure-switching aptamer synthetic nucleic acids [DOI] 10.3390/bios14080376 PMC 바로가기 [Article Type] Review
Organotypic culture of human brain explants as a preclinical model for AI-driven antiviral studiesResource Published on 2024-03-122024-09-05 Journal: EMBO Molecular Medicine [Category] update2024, [키워드] artificial intelligence bunyavirus Computational biology Microbiology, Virology & Host Pathogen Interaction neurotropic virus small molecule Tahyna Virus [DOI] 10.1038/s44321-024-00039-9 PMC 바로가기 [Article Type] Resource
Recent Advances in Real-Time Label-Free Detection of Small MoleculesReview Published on 2024-02-012024-09-05 Journal: Biosensors [Category] update2024, [키워드] biosensor electrochemical transduction Label-free optical transduction piezoelectric transduction Real-time detection small molecule [DOI] 10.3390/bios14020080 PMC 바로가기 [Article Type] Review
Redox modulating small molecules having antimalarial efficacyarticle Published on 2023-12-312024-09-01 Journal: Intervirology [Category] 말라리아, [키워드] antioxidant enzyme Free radicals malaria oxidative stress reactive oxygen species small molecule [Article Type] article
Safety, pharmacodynamics, and antiviral activity of selgantolimod in viremic patients with chronic hepatitis B virus infectionResearch Article Published on 2023-11-302024-09-05 Journal: JHEP Reports [Category] update2024, [키워드] HBV cure Hepatitis B virus Immunotherapy oral antiviral small molecule Toll-like receptor viremic [DOI] 10.1016/j.jhepr.2023.100975 PMC 바로가기 [Article Type] Research Article
Delineation of the distinct inflammatory signaling roles of TAK1 and JAK1 /3 in the CIA model of rheumatoid arthritisOriginal Article Published on 2023-08-112024-09-05 Journal: Pharmacology Research & Perspectives [Category] update2024, [키워드] Inflammation rheumatoid arthritis small molecule TAK1 Therapeutics TNF [DOI] 10.1002/prp2.1124 PMC 바로가기 [Article Type] Original Article
Discovery and structural characterization of chicoric acid as a SARS-CoV-2 nucleocapsid protein ligand and RNA binding disruptorArticle Published on 2022-11-022022-11-15 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] Antiviral antivirals binding C-terminal domain cell cultures compounds coronavirus Critical CTD disrupt Genome identify information isothermal titration calorimetry Ligand ligands N protein N-protein NMR nucleocapsid Protein reduced representing RNA SARS-CoV-2 nucleocapsid SARS-CoV-2 replication small molecule the N protein the SARS-CoV-2 the SARS-CoV-2 genome Transcription [DOI] 10.1038/s41598-022-22576-4 PMC 바로가기
Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infectionArticle Published on 2022-10-042022-11-16 Journal: Cell Reports [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome chromosomal Compound coronavirus Coronavirus infection CP: Immunology Effect Effects highlighting human macrophages identify induce influenza A inhibit inhibitor innate immune innate immune training LPS LPS tolerance Macrophage memory modulate modulation Necrosis NFAT-2 OC43 pro-inflammatory cytokine pro-inflammatory cytokines promote promoter prophylactic treatment reported rutaecarpine. SARS-CoV-2 SARS-COV-2 infection secretion small molecule susceptibility Syk inhibition TNF Tolerance Topology variant [DOI] 10.1016/j.celrep.2022.111441 PMC 바로가기
Computational and experimental insights on the interaction of artemisinin, dihydroartemisinin and chloroquine with SARS-CoV-2 spike protein receptor-binding domain (RBD)Article Published on 2022-10-012022-11-15 Journal: Natural Product Research [Category] COVID19(2023년), SARS, 치료제, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 antimalarial Antiviral agents Artemisinin bind bio-layer interferometry Chloroquine complexes Compound computational tool Coronavirus disease-19 Coronavirus-2 COVID-19 demonstrated derivative docking study domain drug candidate host cell in vitro Interaction interfere Invasion investigated mechanism mechanisms metabolite molecular molecular dynamics predicted Protein RBD SARS-CoV-2 SARS-CoV-2 spike protein small molecule Spike protein stability treat [DOI] 10.1080/14786419.2021.1925894 PMC 바로가기
Peimine inhibits variants of SARS-CoV-2 cell entry via blocking the interaction between viral spike protein and ACE2Article Published on 2022-10-012022-11-16 Journal: Journal of food biochemistry [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome addition Analysis binding affinity block Calu-3 caused cell entry complementary coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients docking drug energy transfer evade exhibit Fritillaria functional glycoprotein Hydrogen bond Infection inhibit inhibit SARS-CoV-2 inhibitor Interaction lung cells molecular docking analysis N501Y patients peimine. Protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 viral infection significantly small molecule suggested suppresse the spike protein treatment for COVID-19 Vaccine variant variant spike variants of concern variants of SARS-CoV-2 viral entry viral infection viral infections viral spike viral spike protein VoC VOCs [DOI] 10.1111/jfbc.14354 PMC 바로가기