Novel antiviral approaches for Marburg: a promising therapeutics in the pipelineMicrobiology Mini Review Published on 2024-04-252024-09-05 Journal: Frontiers in Microbiology [Category] update2024, [키워드] antiviral therapy clinical trials combination therapy drug resistance Immune modulators marburg virus disease RNA interference Small molecule inhibitors [DOI] 10.3389/fmicb.2024.1387628 PMC 바로가기 [Article Type] Microbiology Mini Review
Screening for Active Compounds of Acorus calamus against SARS-CoV-2 Viral Protease and Mechanism PredictionArticle Published on 2024-03-012024-09-05 Journal: Pharmaceuticals [Category] update2024, [키워드] Acorus calamus Coronaviruses SARS-CoV Mpro SARS-CoV PLpro Small molecule inhibitors [DOI] 10.3390/ph17030325 PMC 바로가기 [Article Type] Article
Genetic conservation across SARS-CoV-2 non-structural proteins – Insights into possible targets for treatment of future viral outbreaksReview Published on 2023-03-102024-09-05 Journal: Virology [Category] update2024, [키워드] bioinformatics computer-aided drug design conservation Group IV viruses Non-structural proteins (NSPs) SARS-CoV-2 Sequence alignment Small molecule inhibitors [DOI] 10.1016/j.virol.2023.02.011 PMC 바로가기 [Article Type] Review
Human mpox: Biology, epidemiology, therapeutic options, and development of small molecule inhibitorsReview Published on 2023-03-092023-06-10 Journal: Medicinal research reviews [Category] 원숭이두창, [키워드] Biology Epidemiology mpox Small molecule inhibitors therapeutic options [DOI] 10.1002/med.21943 [Article Type] Review
Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenalReview Published on 2022-09-062022-10-04 Journal: Journal of Biomedical Science [Category] SARS, 변종, 신약개발, [키워드] 3CLpro 3CLpro inhibitors accelerated ACE-2 ACE2 antibody anticipated Antiviral effect approach benefit composed Conjugates conserved Coronaviruses COVID-19 COVID-19 pandemic COVID19 drug Drug discovery effort Evidence FDA approval In-vitro inhibitor Medicinal chemistry monoclonal antibodies peptide-based peptides plethora PLPro PLpro inhibitors Predictive model Prevent Proteases Protein pursuit RdRP RdRp inhibitors Replication reported required researcher S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants small molecule small molecule drug Small molecule inhibitors targets therapeutic option TMPRSS2 TMPRSS2 drug repurposing TMPRSS2 inhibitors Treatment vaccination vaccine platform Vaccines viral entry viral replication [DOI] 10.1186/s12929-022-00847-6 PMC 바로가기 [Article Type] Review
Multifaceted roles of plant derived small molecule inhibitors on replication cycle of SARS-CoV-2SARS-CoV-2의 복제 주기에 대한 식물 유래 소분자 억제제의 다면적 역할Review Published on 2022-07-012022-09-11 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affected Anti-inflammatory anti-SARS-CoV-2 activities Anti-SARS-CoV-2 Activity Anti-viral antioxidant antiviral therapeutics approved assembly caused clinical trial compounds coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 drug candidate Economy Factor Google Scholar help highlight Host inhibiting knowledge mechanism New coronavirus plant plants platform polyprotein public health registry Replication SARS-CoV-2 SARS-COV-2 infection small molecule small molecule inhibitor Small molecule inhibitors Small molecules therapeutic approaches therapy Vaccine viral entry Viral replication cycle. [DOI] 10.1016/j.micpath.2022.105512 PMC 바로가기 [Article Type] Review
A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitorsArticle Published on 2022-03-092023-07-01 Journal: Antiviral Research [Category] COVID19(2023년), SARS, [키워드] 3CLpro cell-based assay High-throughput screening nsp5 SARS-CoV-2 Small molecule inhibitors [DOI] 10.1016/j.antiviral.2022.105272 PMC 바로가기 [Article Type] Article
Unbinding ligands from SARS-CoV-2 Mpro via umbrella sampling simulationsChemistry Published on 2022-01-262022-10-28 Journal: Royal Society Open Science [Category] COVID-19, [키워드] Accuracy Analysis approach ASN142 binding binding affinity correlation coefficient demonstrated experiment free energy Glu166 Gly143 inhibitor Interaction Leu141 Ligand linear mechanism MPro not differ pathway residue SARS-CoV-2 Mpro Small molecule inhibitors SMD Substitution the SARS-CoV-2 umbrella sampling unbinding pathway [DOI] 10.1098/rsos.211480 PMC 바로가기 [Article Type] Chemistry
Future of Therapy for Inborn Errors of ImmunityArticle Published on 2022-01-122024-09-04 Journal: Clinical reviews in allergy & immunology [Category] 대상포진, [키워드] fusion protein Gene therapy inborn errors of immunity monoclonal antibodies newborn screening Primary Immunodeficiency Small molecule inhibitors [DOI] 10.1007/s12016-021-08916-8 PMC 바로가기 [Article Type] Article
Identification of potent small molecule inhibitors of SARS-CoV-2 entrySARS-CoV-2 진입의 강력한 소분자 억제제의 식별Article Published on 2022-01-012022-09-11 Journal: SLAS discovery : advancing life sciences R & D [Category] SARS, 변종, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin angiotensin-converting enzyme 2 Anti-viral drugs assays Cell cellular receptor characterized coronavirus COVID-19 Effectiveness high affinity highlighting HTS identification Immunocompromised infectivity assays inhibitor Interaction molecular docking Mutation novel protease responsible reveal robust SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 protease SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus small molecule small molecule inhibitor Small molecule inhibitors specific inhibitor Spike protein target cells the spike protein the vaccine Transmissibility unique variants variants of SARS-CoV-2 viral spike protein virus entry [DOI] 10.1016/j.slasd.2021.10.012 PMC 바로가기 [Article Type] Article