Detection of Inflammatory Biomarkers Among Patients with Sepsis of Gram-Negative Bacteria: A Cross-Sectional StudyOriginal Research Published on 2023-08-312024-09-05 Journal: International Journal of General Medicine [Category] update2024, [키워드] double-disc synergy test Gram-negative bacteria sepsis biomarkers SOFA score β-lactamase [DOI] 10.2147/IJGM.S415200 PMC 바로가기 [Article Type] Original Research
Identification of COVID-19 patients at risk of hospital admission and mortality: a European multicentre retrospective analysis of mid-regional pro-adrenomedullinObservational Study Published on 2022-08-282022-10-05 Journal: Respiratory Research [Category] SARS, 바이오마커, 임상, [키워드] age Analysis assessment Bacterial infections Classifier collected Combination COVID-19 patient CRP death demographics Department discharge Emergency emergency department Europe European examined failure hospital Hospital admission hospitalisation identification identify IMPROVE in viral increased risk infected with SARS-CoV-2 Infection Inflammatory biomarker International LDH mid-regional pro-adrenomedullin Mortality MR-proADM multicenter multicentre Organ failure outcome Patient patients performed presenting previous study primary endpoint prognostic Prognostic factor random Retrospective analysis risk RT-qPCR Safe SARS-CoV-2 SARS-COV-2 infection secondary care Sepsis Septic shock SOFA SOFA score the patient Treatment utility was performed [DOI] 10.1186/s12931-022-02151-1 PMC 바로가기 [Article Type] Observational Study
ICU strain and outcome in COVID-19 patients-A multicenter retrospective observational studyObservational Study Published on 2022-07-192022-10-04 Journal: PLoS ONE [Category] 임상, [키워드] 28-day mortality Admissions Characteristics Chronic kidney disease collected Coronavirus Disease (COVID)-19 COVID-19 COVID-19 admission COVID-19 patient Cox proportional-hazards model evaluate Factor First wave FIVE France had more hospital Hypoxemia ICU ICU admission intensive care unit intubation less management medical records Mortality multicenter multicentre nasal obesity Older Older age outbreak outcome overweight pandemic Patient prognosis of patient retrospective Retrospective study second wave severity SOFA SOFA score study period [DOI] 10.1371/journal.pone.0271358 PMC 바로가기 [Article Type] Observational Study
SARS-CoV-2 Genomic Characteristics and Clinical Impact of SARS-CoV-2 Viral Diversity in Critically Ill COVID-19 Patients: A Prospective Multicenter Cohort Study중증 COVID-19 환자에서 SARS-CoV-2 게놈 특성 및 SARS-CoV-2 바이러스 다양성의 임상 영향: 전향적 다기관 코호트 연구Observational Study Published on 2022-07-132022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 임상, [키워드] Acute respiratory failure association clinical clinical outcomes COPD COVID-19 COVIDSeq Diversity Endpoint genetic diversity groups had more higher risk hospital ICU admission ICUs Ill Illumina Impact intensive care intensive care unit Mortality multicenter Next-generation sequencing not differ Observational cohort study Older other variant other variants Paris Patient Prospective Respiratory failure SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants sequenced severe COVID-19 significantly SOFA score SOFA scores specific mutations Spread suggested the patient variant variant of concern variants were infected [DOI] 10.3390/v14071529 PMC 바로가기 [Article Type] Observational Study
Specific nutrition and metabolic characteristics of critically ill patients with persistent COVID-19Observational Study Published on 2022-07-012022-10-04 Journal: JPEN. Journal of parenteral and enteral nutrition [Category] 임상, [키워드] Admission C-reactive protein Characteristics characteristics of patient characterized cohorts collected constipation coronavirus disease COVID-19 COVID-19 patient Critical Critically ill patient defined demographic data diarrhea energy balance energy deficit Enteral faster gastrointestinal function Hospital stay hypophosphatemia ICU ICU protocol in both group Infection intestinal intubation less Lipid men Mortality mortality rate neuromuscular blockade non-respiratory organ nutrition obese obese patients Patient patients patients with COVID-19 patients without COVID-19 Prone position propofol proportion prospective observational study Protein reduced refeeding syndrome risk Screening Sedation severity scores significantly more SOFA score SOFA scores Specific syndrome target underfeeding. variables with COVID-19 [DOI] 10.1002/jpen.2334 PMC 바로가기 [Article Type] Observational Study
Immunometabolic analysis shows a distinct cyto-metabotype in Covid-19 compared to sepsis from other causesResearch article Published on 2022-06-242022-10-05 Journal: Heliyon [Category] 바이오마커, 치료기술, [키워드] accompanied Analysis cause CD14+ CD14+ monocyte CD8+ T cells change characteristic Cohort concentrations controls correlated COVID-19 Critical cytokine Cytokine release syndrome Disease progression disease severity expression flow cytometry greater healthy control Hypothesis immune checkpoint immune response immunometabolism involved Lipid mechanism metabolic derangement metabolic risk factor metabolism monocytopenia mononuclear cell multiplex pandemic Pathway analysis Patient PBMC PBMCs PD-L1 Peripheral blood Phosphatidylcholine plasma plasma concentration recruited reduced reflect Result Sepsis serum severe cases severity shown SOFA score Support systemic inflammatory response the disease Treg Tryptophan unique was increased was performed [DOI] 10.1016/j.heliyon.2022.e09733 [Article Type] Research article
Early dexamethasone use as a protective measure in non-mechanically ventilated critically ill patients with COVID-19: a multicenter, cohort study Research Published on 2022-06-132022-10-05 Journal: Scientific Reports [Category] 임상, 치료법, [키워드] 1:1 24 hour benefit cohort study consequence COVID-19 COVID19 Critically ill patient debatable Dexamethasone higher odd hospital ICU admission ICUs in-hospital mortality initiated intensive care unit LOS mechanical ventilation Mortality multicenter multicenter cohort study outcome Patient patients with COVID-19 Prevent primary endpoint Propensity score Protective required Respiratory failure SOFA score statistically significant the timing Tocilizumab two group Ventilated ventilated patients was used with COVID-19 [DOI] 10.1038/s41598-022-13239-5 [Article Type] Research
Aberrant Fibrin Clot Structure Visualized Ex Vivo in Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 InfectionObservational Study Published on 2022-06-012022-10-05 Journal: Critical Care Medicine [Category] 임상, [키워드] acute respiratory syndrome age anticoagulation assessment Biomarkers body mass index buffer clot Coagulation Cohort Comorbidities contribute coronavirus coronavirus 2 COVID-19 COVID-19 patient Critically ill patient cross-sectional determine died failure fibrin clot fluorescent functional Gender ICU ICU admission ICU patient Ill implication Infection interquartile range Laboratory measurement median microthrombi Mortality outcome Patient patients with COVID-19 patients without COVID-19 plasma positively correlated reported required respiratory Sepsis SOFA SOFA score Structure was collected was used widespread with COVID-19 [DOI] 10.1097/CCM.0000000000005465 PMC 바로가기 [Article Type] Observational Study
Characteristics and outcomes of sepsis patients with and without COVID-19Research article Published on 2022-06-012022-10-05 Journal: Journal of infection and public health [Category] 바이오마커, [키워드] Acute kidney injury acute respiratory distress syndrome adjusted adjusted relative risk AKIAcute Kidney Injury Analysis analyzed ARDSacute respiratory distress syndrome BMIbody mass index body mass index C-reactive protein Characteristics CIconfidence interval Clinical characteristics confidence interval Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients COVID-19coronavirus disease 2019 Critically ill CRPC-reactive protein CRScytokine release syndrome Cytokine release syndrome diagnosed ECMOextracorporeal membrane oxygenation extracorporeal membrane oxygenation facilitate HAIHospital acquired infection High-risk patients Hospital acquired infection ICU admission ICU patient ICUIntensive Care Unit identify IL-6interleukin 6 in-hospital mortality independent risk factor Inhaled nitric oxide iNOInhaled nitric oxide intensive care unit interleukin 6 invasive ventilation Kaplan-Meier estimator lactate dehydrogenase LDHlactate dehydrogenase medical icu Mortality not differ outcome Patient patients PCT PCTProcalcitonin Poisson regression procalcitonin Relative risk renal replacement therapy Result risk factor robust RRRelative risk RRTRenal replacement therapy screened Sepsis sepsis patient sepsis patients septic patient septic patients Septic shock sequential organ failure assessment score Sex significantly significantly higher SOFA score SOFA scoreSequential organ failure assessment score surgical survival treated university were assessed WHOWorld Health Organization World Health Organization [DOI] 10.1016/j.jiph.2022.05.008 [Article Type] Research article
Clinical and laboratory predictors at ICU admission affecting course of illness and mortality rates in a tertiary COVID-19 center3차 COVID-19 센터의 질병 경과 및 사망률에 영향을 미치는 ICU 입원 시 임상 및 실험실 예측 변수Observational Study Published on 2022-05-012022-09-11 Journal: Heart & lung : the journal of critical care [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 임상, 치료기술, [키워드] Admission affected affecting age Analysis analyzed applied Arterial hypertension bacterial superinfections baseline clinical clinical feature Clinical features Cohort Comorbidities congestive heart failure Course COVID-19 COVID-19 patient COVID-19 patients Critical care Critically ill critically ill COVID-19 patients Croatia CRP determine Factor Features hospital hypertension ICU ICU admission IL-6 increase Inflammatory biomarker Invasive mechanical ventilation Laboratory laboratory parameter Laboratory parameters Length Mortality mortality rate mortality rates mortality risk multivariate adjustment outcome PaO predict predictor primary endpoint primary endpoints Regression model retrospective risk factor Risk factors Serum ferritin SOFA SOFA score survival survival analysis survival rates Survivors therapeutic intervention therapeutic interventions treated Trial utility [DOI] 10.1016/j.hrtlng.2022.01.013 PMC 바로가기 [Article Type] Observational Study