Potential pitfalls in analysing a SARS-CoV-2 RT-PCR assay and how to standardise data interpretationSARS-CoV-2 RT-PCR 분석 및 데이터 해석을 표준화하는 방법 분석의 잠재적 함정Article Published on 2022-10-012022-09-11 Journal: Journal of virological methods [Category] COVID19(2023년), SARS, 치료기술, [키워드] addition analysed Applied Biosystem Audit automated baseline Baseline threshold carried complex data interpretation determine Diagnostics.ai Frequency implementation in some increase in Interpretation introduced investigated Laboratory manual intervention Patient PCR positive result Potential processed produced provide Real-time PCR real-time RT-PCR relative Relative threshold RT-PCR RT-PCR kit RT-PCR kits SARS-CoV-2 SARS-CoV-2 RT-PCR solution tested thermocyclers threshold time-consuming virus detection was determined [DOI] 10.1016/j.jviromet.2022.114589 PMC 바로가기 [Article Type] Article
An electrochemical aptasensor with N protein binding aptamer-complementary oligonucleotide as probe for ultra-sensitive detection of COVID-19N 단백질 결합 앱타머-상보성 올리고뉴클레오티드를 COVID-19의 초고감도 검출을 위한 프로브로 사용하는 전기화학적 앱타센서Article Published on 2022-10-012022-09-11 Journal: Biosensors & bioelectronics [Category] 치료기술, 치료제, [키워드] affected applied aptamer binding blood sample Blood samples changes in complementary Complementary DNA Concentration conformational COVID-19 COVID-19 epidemic COVID-19 in patients DNA double-stranded Early detection effective Electrochemical aptasensor gold hybridization Incubation linear relationship log logarithm N protein N protein detection probe R 2 Rapid Rapid COVID-19 diagnosis Regenerable aptamer sensor. reported sensor solution target the N protein throat swab throat swabs vaccination volunteers was measured [DOI] 10.1016/j.bios.2022.114436 PMC 바로가기 [Article Type] Article
The impact of COVID-19 restrictions on participant enrollment in the PREPARE trialResearch article Published on 2022-10-012022-10-05 Journal: Contemporary Clinical Trials Communications [Category] 임상, [키워드] affected approval clinical trials COVID-19 COVID-19 pandemic COVID-19 research Enrollment Evaluating extremities implementation interquartile range median pandemic participant Patient Pragmatic pragmatic trials PREPARE trial protocol recorded researcher Result significantly lower skin solution t-test Trial [DOI] 10.1016/j.conctc.2022.100973 [Article Type] Research article
PEDOT:PSS in Solution Form Exhibits Strong Potential in Inhibiting SARS-CoV-2 Infection of the Host Cells by Targeting Viruses and Also the Host CellsArticle Published on 2022-09-122022-11-16 Journal: Biomacromolecules [Category] SARS, 변종, [키워드] ACE2-expressing cell acute respiratory syndrome antiviral activity blocked caused Cell cells Combination coronavirus Culture cytotoxicity Effect exhibited form global pandemic high mutation rate inhibitor investigated medium Mutation Potential Prophylactic pseudovirus SARS-CoV-2 SARS-CoV-2 pseudovirus infection SARS-CoV-2 variant solution Spike protein Strong targeting the SARS-CoV-2 the spike protein therapeutic transcriptional transcriptomic data Transmission treated Treatment variants virus [DOI] 10.1021/acs.biomac.2c00271 PMC 바로가기
Considering epitopes conservity in targeting SARS-CoV-2 mutations in variants: a novel immunoinformatics approach to vaccine design변이체에서 SARS-CoV-2 돌연변이 표적화에서 에피토프 보존성 고려: 백신 설계에 대한 새로운 면역정보학 접근Article Published on 2022-08-182022-09-11 Journal: Scientific Reports [Category] SARS, 변종, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptive Adaptive immunity antibody antigenicity approach Avian flu calculated collected conserved Coronavirus-2 database Developing Efficacy epitope Epitopes event flu ideal identify IEDB immune Immune Epitope Database Immunity immunodominant immunogenicity immunoinformatics mutated Mutation mutations neutralization pathogenicity platform predicted preference provide reduce Region SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 mutation selected Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Shannon entropy similarity solution technique Vaccine design Vaccines variant variants virulence virus viruses [DOI] 10.1038/s41598-022-18152-5 PMC 바로가기 [Article Type] Article
SARS-CoV-2-positive patients display considerable differences in proteome diversity in urine, nasopharyngeal, gargle solution and bronchoalveolar lavage fluid samplesSARS-CoV-2-양성 환자는 소변, 비인두, 양치액 및 기관지폐포 세척액 샘플에서 단백질체 다양성에 상당한 차이를 나타냅니다.Article Published on 2022-08-082022-09-11 Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 BALF Beijing Bronchoalveolar lavage fluid center chance change characterized Charle China collected coronavirus coronavirus 2 database demonstrated Department downloaded followed by gargle gargle solution Germany Human human body in urine individual infected with SARS-CoV-2 Infection information investigated Mayo Clinic Medicine nasopharyngeal nasopharyngeal sample Nasopharyngeal samples pathology peptide Protein Proteins proteome proteomic proteomics respiratory SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV-2 proteome SARS-CoV-2 virus SARS-CoV-2 viruses SARS-CoV-2-positive patient SARS-CoV-2-positive patients Science secreted seropositive individuals Severe acute respiratory syndrome significantly more solution status technology the SARS-CoV-2 virus UniProt unique university Urine USA virus viruses was used while [DOI] 10.1371/journal.pone.0271870 PMC 바로가기 [Article Type] Article
Determination of rSpike Protein by Specific Antibodies with Screen-Printed Carbon Electrode Modified by Electrodeposited Gold Nanostructures전착된 금 나노구조에 의해 변형된 스크린 인쇄된 탄소 전극이 있는 특정 항체에 의한 rSpike 단백질의 측정Article Published on 2022-08-032022-09-11 Journal: Biosensors [Category] SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 albumin antibodies antibody antigen–antibody complex applicability binding Blood bovine bovine serum albumin carbon changed coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cyclic voltammetry (CV) Determination differential pulse voltammetry (DPV) DPV electrochemical immunosensor electrochemical impedance spectroscopy (EIS) electrode electron transfer evaluated exhibit gold gold nanostructures (AuNS) heterogeneous Interaction L-cysteine limit limit of detection nanostructure nonspecific Patient Protein pulse quantification rate constant Research respiratory SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 virus self-assembled monolayer (SAM) serum serum albumin severe acute respiratory syndrome Coronavirus solution Specific specific antibodies specific antibody specificity spike Spike protein spike protein (Spike). Spike proteins surface area was performed was used were assessed [DOI] 10.3390/bios12080593 PMC 바로가기 [Article Type] Article
Simulation of group testing scenarios can boost COVID-19 screening power그룹 테스트 시나리오의 시뮬레이션은 COVID-19 스크리닝 능력을 높일 수 있습니다Article Published on 2022-07-132022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료기술, [키워드] affected approach boost COVID-19 COVID-19 dissemination dependent on detect disease Disease prevalence dissemination group health system health systems individual mass mitigate positive individuals power Prevalence quarantine reagents shortage of reagent Simulation solution stages the disease Viral load [DOI] 10.1038/s41598-022-14626-8 PMC 바로가기 [Article Type] Article
Protection of hamsters challenged with SARS-CoV-2 after two doses of MVC-COV1901 vaccine followed by a single intranasal booster with nanoemulsion adjuvanted S-2P vaccineMVC-COV1901 백신 2회 접종 후 SARS-CoV-2에 감염된 햄스터 보호 및 나노에멀젼 보조제 S-2P 백신이 포함된 단일 비강 내 부스터Article Published on 2022-07-052022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] alum booster booster vaccination country COVID-19 COVID-19 vaccine COVID-19 vaccines CpG1018 death Delta disease dose elicit followed by hamster Hospitalization Immunity immunization immunogenicity Infection intramuscular intranasal Lung pathology medical need mucosal offer omicron Pandemics Patient prefusion problem promote protection protective immunity protocol reduced regimen respiratory respiratory tracts resurgence robust S-2P SARS-CoV-2 SARS-CoV-2 spike severe COVID-19 severe disease solution Transmission vaccination Vaccine variants variants of SARS-CoV-2 Viral viral challenge viral clearance viral infection waning immunity weight loss were used [DOI] 10.1038/s41598-022-15238-y PMC 바로가기 [Article Type] Article
One Solution for All: Searching for Universal Aptamers for Constantly Mutating Spike Proteins of SARS-CoV-2모두를 위한 하나의 솔루션: SARS-CoV-2의 스파이크 단백질을 지속적으로 돌연변이시키기 위한 범용 앱타머 검색Article Published on 2022-07-052022-09-11 Journal: ChemMedChem [Category] COVID19(2023년), SARS, 변종, [키워드] aptamer binding bioinformatic analysis COVID-19 demonstrated develop diagnostics DNA effort experiment followed by high affinity Mutation overcome pool producing Protein recognize S protein S protein variant SARS-CoV-2 sequence significantly solution specificity spike Spike protein the S protein the spike protein Therapeutics Universal variant variants variants of concern virus VOCs wildtype [DOI] 10.1002/cmdc.202200166 PMC 바로가기 [Article Type] Article