Pre-vaccination RT-PCR negative contacts in workplace settings show high, SARS COV-2 neutralizing antibody levelsArticle Published on 2022-10-252022-11-15 Journal: BMC Public Health [Category] COVID19(2023년), SARS, 진단, [키워드] age anti-SARS-CoV-2 antibody carried characterized Cohort cohort study collected Contact COVID-19 evaluated individual Infection infection control measure neutralization Neutralizing antibodies neutralizing antibody Outbreaks PCR PCR negative contacts positive Protective Ratio risk factor Risk factors RT-PCR SARS-CoV-2 SARS-COV-2 infection selected Seroprevalence significantly higher specific neutralizing antibody tested Transmission dynamics transmission of SARS-CoV-2 vaccination was tested while Workplace Workplace settings. [DOI] 10.1186/s12889-022-14381-5 PMC 바로가기
Molecular Docking and In-Silico Analysis of Natural Biomolecules against Dengue, Ebola, Zika, SARS-CoV-2 Variants of Concern and Monkeypox VirusArticle Published on 2022-09-222022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 변종, 진단, 치료제, [키워드] Amino acid AMP AMPs antimicrobial peptide Antiviral antiviral drug Antiviral treatment AutoDock vina B.1.617.2 Bacterial bacterial AMPs binding energy Biomolecule biomolecules Cell cell receptor cell surface receptors concern Control Dengue dengue virus determine develop docking docking score Ebola Ebola virus Effective vaccines envelope protein Evolution in silico increase in indicated Modification molecular molecular docking Monkeypox mutant natural Occurrence P.1 pathogenic viruses positive proline Protein receptors SARS-CoV-2 Secondary Metabolite specific neutralizing antibody tested the SARS-CoV-2 the spike protein therapeutic agents variant variants of SARS-CoV-2 viral cell viral surface virus was performed Zika Zika virus [DOI] 10.3390/ijms231911131 PMC 바로가기
Comparison of IgA, IgG, and Neutralizing Antibody Responses Following Immunization With Moderna, BioNTech, AstraZeneca, Sputnik-V, Johnson and Johnson, and Sinopharm’s COVID-19 VaccinesModerna, BioNTech, AstraZeneca, Sputnik-V, Johnson and Johnson 및 Sinopharm의 COVID-19 백신을 사용한 면역 후 IgA, IgG 및 중화 항체 반응의 비교Article Published on 2022-06-212022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] age Analysis analyzed antibody Antibody titers AstraZeneca automated binding blood sample categories category Combination comparable Correlation analysis COVID-19 COVID-19 vaccines demonstrated DNA dose doses effective ELISA expression group groups Heterologous highest homologous IgA IgG immunogenic investigated lowest moderate Moderna mRNA vaccine negative correlation neutralization Neutralizing Neutralizing antibodies neutralizing antibody Older reactogenicity response sandwich ELISA SARS-CoV-2 sera significant increase significantly higher Sinopharm Spearman specific neutralizing antibody statistically Trial vaccination Vaccination strategy Vaccine vaccinee vaccinees vectored vaccine virus Virus neutralization Virus-specific IgG Volunteer [DOI] 10.3389/fimmu.2022.917905 PMC 바로가기 [Article Type] Article
Evaluation of Two Rapid Lateral Flow Tests and Two Surrogate ELISAs for the Detection of SARS-CoV-2 Specific Neutralizing AntibodiesMedicine Published on 2022-02-042022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] collected convalescent patient COVID-19 detection diagnostics ELISA Euroimmun evaluated Flow highest Lateral lateral flow lateral flow assay lowest negative control sample neutralization Neutralizing antibodies Rapid SARS-CoV-2 sensitivity sera serological significant difference Specific specific neutralizing antibody specificity surrogate Test tested vaccinated individual vaccinated individuals vaccination [DOI] 10.3389/fmed.2022.820151 PMC 바로가기 [Article Type] Medicine
Antibody Response against SARS-CoV-2 Infection: Implications for Diagnosis, Treatment and Vaccine DevelopmentSARS-CoV-2 감염에 대한 항체 반응: 진단, 치료 및 백신 개발에 미치는 영향Review Published on 2022-01-012022-09-12 Journal: International reviews of immunology [Category] SARS, 진단, [키워드] antibody Antibody Response Characteristics convalescent plasma Convalescent plasma therapy development diagnostic Efficacy and safety humoral humoral response to COVID-19 infected patient infected patients infections information monoclonal Neutralizing neutralizing monoclonal antibodies neutralizing monoclonal antibody produced provided Quantitative reported response robust SARS-CoV-2 SARS-COV-2 infection serologic tests specific neutralizing antibody specificity therapeutic options Vaccine Vaccine design [DOI] 10.1080/08830185.2021.1929205 PMC 바로가기 [Article Type] Review
Effect of BCG Revaccination on Occupationally Exposed Medical Personnel Vaccinated against SARS-CoV-2SARS-CoV-2 예방 접종을 받은 직업적으로 노출된 의료진에 대한 BCG 재접종의 영향Article Published on 2021-11-152022-09-12 Journal: Cells [Category] MERS, SARS, 진단, [키워드] Administered allele anti-SARS-CoV-2 BCG both group Concentration confounding effect COVID-19 COVID-19 patients cytokine Effect exhibited Frequency genotyped GM-CSF group HLA-DRB1 IL-12p70 IL-13 IL-18 IL-1β IL-4 IL-6 individual INF-γ loci Neutralizing antibodies neutralizing antibody neutralizing antibody titers nine participant Patient Placebo protocol Randomized reducing revaccination SARS-CoV-2 serum serum cytokine severe COVID-19 specific neutralizing antibody subsequent thought TNF-α vaccination Vaccine vaccine group was determined [DOI] 10.3390/cells10113179 PMC 바로가기 [Article Type] Article
Chemiluminescence Immunoassay Based Serological Immunoassays for Detection of SARS-CoV-2 Neutralizing Antibodies in COVID-19 Convalescent Patients and Vaccinated PopulationCOVID-19 회복기 환자 및 백신 접종 된 집단에서 SARS-COV-2 중화 항체의 검출을위한 화학 발광 면역 분석 기반 혈청 학적 면역 분석Article Published on 2021-07-302022-09-01 Journal: Viruses [Category] SARS, 진단, 치료기술, [키워드] ACE2-RBD ACE2-RBD binding ACE2-RBD inhibition assay antibody calculated chemiluminescence chemiluminescence immunoassay Concentration correlated correlation COVID-19 COVID-19 convalescent patient COVID-19 patients detection diagnosis of COVID-19 diagnostic Donor evaluate evaluated healthy donor healthy donors high affinity human sera immunization inhibiting inhibiting antibody Microneutralization test MNT neutralization test neutralization tests Neutralizing antibodies neutralizing antibody patients Population Quantitative SARS-CoV-2 SARS-CoV-2 vaccine sera serological significantly specific neutralizing antibody value was used were used [DOI] 10.3390/v13081508 PMC 바로가기 [Article Type] Article
Computational design and modeling of nanobodies toward SARS-CoV-2 receptor binding domainSARS-CoV-2 수용체 결합 도메인에 대한 나노바디의 컴퓨터 설계 및 모델링Article Published on 2021-07-012022-09-12 Journal: Chemical biology & drug design [Category] SARS, 진단, [키워드] ACE2 ACE2 binding site acute respiratory syndrome addition angiotensin-converting enzyme 2 binding binding affinity binding domain binding mechanism caused CDRs complementarity-determining region complex computational protein design Contact coronavirus coronavirus disease COVID-19 docking domain effective FIVE free energy landscape grafting Health host cell host cells include Infection information inhibit Interaction mAb mAbs mechanism MERS-CoV monoclonal antibody nanobody Neutralizing neutralizing nanobody pandemic predicted Prevent Protein Protein docking RBD reported residue SARS-CoV SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 receptor selected sequence Seven specific neutralizing antibody Spike protein Spread stability Structure structures therapeutic drug virus virus infection [DOI] 10.1111/cbdd.13847 PMC 바로가기 [Article Type] Article
Utility of Different Surrogate Enzyme-Linked Immunosorbent Assays (sELISAs) for Detection of SARS-CoV-2 Neutralizing AntibodiesArticle Published on 2021-05-142022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] Abbott ACE2 antibody automated BNT162b2 clinical samples conditions COVID-19 cut-off value demonstrated detection ELISAs enzyme-linked immunosorbent assay evaluated examined Follow-up functional Genscript Germany IgG antibody immunoassay Laboratory safety Mainz Neutralizing antibodies performed plaque reduction neutralization PRNT Quantitative ranged reference method SARS-CoV-2 sensitivity serum samples specific neutralizing antibody specificity spike surrogate surrogate ELISA Switzerland Test USA vaccinated individuals Wiesbaden York [DOI] 10.3390/jcm10102128 PMC 바로가기 [Article Type] Article
Endogenously Produced SARS-CoV-2 Specific IgG Antibodies May Have a Limited Impact on Clearing Nasal Shedding of Virus during Primary Infection in Humans내인적으로 생성된 SARS-CoV-2 특이적 IgG 항체는 인간의 1차 감염 동안 바이러스의 비강 배출 제거에 제한적인 영향을 미칠 수 있음Article Published on 2021-03-202022-09-01 Journal: Viruses [Category] SARS, 진단, [키워드] antibody antibody kinetics antigenic antigenic stimulation binding characterized Clearing Clinical severity ENhance Human IgG IgG and IgM IgG antibodies IgG level IgG levels IgM antibodies Immunity Impact Infection isotype Limited mathematical mathematical model Mathematical models Mitigation nasal passage nasal passages natural infection neutralization no effect occur Primary infection production rate resulting SARS-CoV-2 SARS-CoV-2 viral severe disease severity shedding Specific specific IgG antibodies specific IgG antibody specific neutralizing antibodies specific neutralizing antibody symptom onset therapeutic purposes Trigger triggers vaccination Viral viral clearance viral dynamics virus while [DOI] 10.3390/v13030516 PMC 바로가기 [Article Type] Article