(+)-Usnic Acid and Its Derivatives as Inhibitors of a Wide Spectrum of SARS-CoV-2 VirusesArticle Published on 2022-09-292022-11-15 Journal: Viruses [Category] SARS, 치료제, [키워드] acid Antiviral antiviral action antiviral activity Antiviral compound binding site Compound compounds Delta derivative exhibit glycoprotein hemoglobin inhibitory activity main viral protease 3CLPro mechanism metabolite molecular Molecular modeling N-terminal domain omicron performed protease SARS-CoV-2 SARS-CoV-2 virus shown Spectrum strain Strains Surface glycoprotein surface glycoprotein S usnic acid virus virus SARS-CoV-2. Wuhan [DOI] 10.3390/v14102154 PMC 바로가기
Morphological, cellular, and molecular basis of brain infection in COVID-19 patients코로나19 환자 뇌 감염의 형태적, 세포적, 분자적 기초Article Published on 2022-08-302022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration anxiety symptoms Astrocyte astrocytes biogenesis Brain brain damage Brain infection brain tissue brains cellular changes in characterized Cohort contribute coronavirus cortical Cortical atrophy COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients death deregulated died dysfunction elicit energy metabolism Evidence exhibited fatigue FIVE foci functional genetic material guide histopathological sign histopathological signs Hypothesis impairment in vitro independent individual infect infected individual Infection Interaction manifestation manifested mechanism metabolism metabolite metabolites mild infection molecular basis neural stem cell Neurological symptoms neuronal neurons Neuropsychiatric Neurotransmitters NRP1 Patient phenotype Protein reduce Replication SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Severe COVID-19 Infection Spectrum Support Supporting susceptible syndrome tissue sample viability virus [DOI] 10.1073/pnas.2200960119 PMC 바로가기 [Article Type] Article
Prospective Evaluation of Coronavirus Disease 2019 (COVID-19) Vaccine Responses Across a Broad Spectrum of Immunocompromising Conditions: the COVID-19 Vaccination in the Immunocompromised Study (COVICS)광범위한 면역 손상 조건에 걸친 코로나바이러스 질병 2019(COVID-19) 백신 반응의 전향적 평가: 면역 손상 연구(COVICS)의 COVID-19 백신 접종Article Published on 2022-08-242022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 진단, [키워드] acute respiratory syndrome adenovirus vector vaccine age anti-CD20 antibody antibody level Antibody Response approach autoimmune condition autoimmune conditions BNT162b2 cause comparison coronavirus coronavirus disease correlated correlation COVID-19 COVID-19 vaccine COVID-19 vaccines domain Factor greater HCW HCWs healthcare worker Hematologic malignancy Hematological malignancy HIV Human immunodeficiency virus Humoral response identify Immunocompromised immunocompromised adult immunocompromised individual Immunocompromised patient immunodeficiency Immunoglobulin Immunosuppression Logistic regression lowest Messenger RNA Moderna monoclonal monoclonal antibodies mRNA-1273 neutralization titer neutralization titers outcome participant Pfizer Primary outcome proportion Prospective pseudovirus reactive recipient recipients response SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 neutralization secondary seropositive seropositive participant significantly lower solid cancers solid organ transplant solid tumor SOT Spearman Spectrum vaccination Vaccine was used [DOI] 10.1093/cid/ciac103 PMC 바로가기 [Article Type] Article
Differences and similarities in endothelial and angiogenic profiles of preeclampsia and COVID-19 in pregnancy임신 중 자간전증 및 COVID-19의 내피 및 혈관 신생 프로파일의 차이 및 유사성Article Published on 2022-08-012022-08-31 Journal: American journal of obstetrics and gynecology [Category] MERS, 바이오마커, 진단, [키워드] absence activate addition Adhesion Molecule alteration Analysis Angiogenesis angiogenic factors angiopoietin Antigen Biomarker Biomarkers C5b9 Cell cell membrane cell membranes Cell signaling change changes in circulating Coagulation Coagulopathy component Concentration Control controls COVID-19 COVID-19 infection COVID-19 patients Culture demonstrated difference differential diagnosis differentiation disease disorder endothelial Endothelial cell endothelial cells endothelial damage Endothelial dysfunction evaluated exhibited expected explained expression Extracellular Extracellular matrix group growth growth factor healthy heparan sulfate hypertensive hypertensive disorders of pregnancy Immunoblots immunofluorescence in some in vitro increase in Infection Inflammation inflammatory signaling innate immune response intercellular intercellular adhesion molecule less lysate lysates Mild mitogen-activated protein kinase Necrosis neutrophil Neutrophil extracellular trap Neutrophil extracellular traps normotensive overexpression Pathways Patient Phosphorylation placental placental growth factor preeclampsia Pregnancy pregnant women Principal component principal component analysis profile profiles Protein protein kinase receptor reduced reduction reduction in SARS-CoV-2 sera severe COVID-19 severe COVID-19 patient signaling pathway significant increase significantly increased Signs and symptoms similarity soluble fms-like tyrosine kinase-1 soluble tumor necrosis factor-α receptor I Spectrum statistical analysis statistically Study design sulfate Symptom Tumor tumor necrosis tumor necrosis factor-α tyrosine variable variance vascular cell adhesion von Willebrand disease von Willebrand factor with COVID-19 women [DOI] 10.1016/j.ajog.2022.03.048 PMC 바로가기 [Article Type] Article
COVID-19 and Guillain-Barré syndrome: A single-center prospective case series with a 1-year follow-upCOVID-19 및 Guillain-Barré 증후군: 1년 추적 관찰이 포함된 단일 센터 전향적 사례 시리즈Observational Study Published on 2022-07-292022-09-11 Journal: Medicine [Category] COVID19(2023년), SARS, 변종, 임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Admission antecedent antibody association bystander Case report case reports case sery cerebrospinal fluid clinical clinical feature Clinical presentations Clustering Computerized tomography consecutive patient coronavirus COVID-19 diagnosed disability feature Follow-up Guillain-barrè syndrome highlight hospital incidence Infection involved Italian Laboratory lack lymphopenia Medical Research Council Nasopharyngeal swab neurological Neurological diseases no difference no differences observational study pandemic patients patients with SARS-CoV-2 Pneumonia positive Prevalence Prognosis reduction Referral Region reported response to treatment retrospective SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus severity single-center Spectrum subtype Support Swab syndrome systemic inflammation Temporal Treatment university Waves while X-ray [DOI] 10.1097/MD.0000000000029704 PMC 바로가기 [Article Type] Observational Study
Real-life data on monoclonal antibodies and antiviral drugs in Italian inborn errors of immunity patients during COVID-19 pandemic코로나19 팬데믹 기간 동안 이탈리아 선천성 면역질환 환자의 단클론항체 및 항바이러스제 실생활 데이터Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] Alpha Analysis Antiviral antiviral agent Antiviral agents antiviral drug antiviral drugs Asymptomatic Care circulating Cohort contributed Course COVID-19 COVID-19 pandemic COVID-19 severity disease disease severity duration of viral shedding Effect Efficacy error evaluated Hospital admission Hospitalization hospitalization-risk hospitalizations hospitalized patients ICU admission Immunity immunized Inborn Inborn errors inborn errors of immunity Infection Italian longitudinal lower risk mAbs mitigate monoclonal monoclonal antibodies monoclonal antibody Mortality mRNA vaccine mRNA vaccines offered Patient patients treated performed positive Prevent prophylactic measure prophylactic measures Re-infection Re-infections reduce reduced Reinfection reported respond risk Safe SARS-CoV-2 SARS-CoV-2 infected patients SARS-CoV-2 positivity SARS-CoV-2 strains SARS-CoV-2 virus severe COVID-19 severe disease Spectrum Spread Strains therapeutic therapy treated vaccination Vaccinations Viral viral shedding viral strain viral strains widespread [DOI] 10.3389/fimmu.2022.947174 PMC 바로가기 [Article Type] Article
In vitro activity of therapeutic antibodies against SARS-CoV-2 Omicron BA.1, BA.2 and BA.5SARS-CoV-2 Omicron BA.1, BA.2 및 BA.5에 대한 치료 항체의 시험관 내 활성Article Published on 2022-07-232022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] active against Alter antibody cilgavimab D614G delta variant European Fold change growth less Lineage lineage B.1 monoclonal antibodies monoclonal antibody Mutation neutralising not enhanced omicron reduction replacement SARS-CoV-2 significantly Sotrovimab Spectrum spike glycoprotein strain therapeutic therapeutic antibodies Tixagevimab union variant of SARS-CoV-2 variants [DOI] 10.1038/s41598-022-16964-z PMC 바로가기 [Article Type] Article
Genomic surveillance of SARS-CoV-2 in patients presenting neurological manifestations신경학적 징후를 보이는 환자에서 SARS-CoV-2의 게놈 감시Article Published on 2022-06-302022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Ageusia analyzed Anosmia Anosmia/ageusia approach Cell Central nervous system CNS coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient evaluate explain feature First wave genomic Genomic surveillance group Host in vitro in vivo individual infections Mutation Nasopharyngeal swab nasopharyngeal swabs neurological manifestation neurological manifestations Neurological symptom Neurological symptoms occur Patient patients presenting raised SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 positive patient selected severe acute respiratory syndrome Coronavirus severe symptoms shown Spectrum subset Support viral fitness viral genome viral sequence viral sequences virus was related while whole genome sequence [DOI] 10.1371/journal.pone.0270024 PMC 바로가기 [Article Type] Article
Borneol Ester Derivatives as Entry Inhibitors of a Wide Spectrum of SARS-CoV-2 Viruses광범위한 SARS-CoV-2 바이러스의 진입 억제제로서의 보르네올 에스테르 유도체Article Published on 2022-06-142022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료제, [키워드] antiviral activity binding site borneol carried Compound conserved coronavirus coronavirus surface protein S-spike Delta derivative domain early stage early stages ester glycoprotein Glycoproteins heptad repeat Ligand ligands molecular molecular docking molecular dynamics nitrogen omicron protein S pseudoviral system Region SARS-CoV-2 SARS-CoV-2 virus SARS-CoV-2 virus strains SARS-CoV-2 viruses searched Spectrum strain Strains suggested surface protein terpene the SARS-CoV-2 virus viral replication Wuhan [DOI] 10.3390/v14061295 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Continuous Genetic Divergence and Changes in Multiplex RT-PCR Detection Pattern on Positive Retesting Median 150 Days after Initial InfectionSARS-CoV-2 지속적인 유전적 분화 및 초기 감염 후 150일의 양성 재검사 중앙값에 대한 다중 RT-PCR 검출 패턴의 변화Article Published on 2022-06-022022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, 치료법, 치료제, [키워드] accumulate amplification Amplification assay analyzed being Chain Reaction change Clinical diagnosis Continuous COVID-19 COVID-19 pandemic Day detection diagnostic Divergence envelope gene epicenter Epidemiology evaluated Evolution Frequency gene amplification Genetic genetic divergence genomes highlight hotspot identify in viral independent Infection initial isolate isolates lab molecular molecular evolution multiplex Multiplex RT-PCR Mutation next generation sequencing NGS Nucleocapsid gene Patient pattern performed polymerase chain polymerase chain reaction positive primer probe Region Reinfection reverse transcription reverse transcription polymerase chain reaction RT-PCR SARS-CoV-2 SARS-CoV-2 RNA specimen Spectrum target tested utility Viral viral genome viral genomes Viral variants virus WGA whole genome [DOI] 10.3390/ijms23116254 PMC 바로가기 [Article Type] Article