Vero cell-adapted SARS-CoV-2 strain shows increased viral growth through furin-mediated efficient spike cleavageResearch Article Published on 2024-04-282024-09-05 Journal: Microbiology Spectrum [Category] update2024, [키워드] Infection pathogenicity severe acute respiratory syndrome virus-2 (SARS-CoV-2) spike (S) protein viral replication [DOI] 10.1128/spectrum.02859-23 PMC 바로가기 [Article Type] Research Article
Monoclonal antibody designed for SARS-nCoV-2 spike protein of receptor binding domain on antigenic targeted epitopes for inhibition to prevent viral entryArticle Published on 2023-04-012023-07-09 Journal: Molecular diversity [Category] COVID19(2023년), [키워드] cellular immune responses COVID19 Human receptor angiotensin converting enzyme-2 (hACE2) monoclonal antibody receptor binding domain (RBD) Severe acute respiratory syndrome-coronavirus (SARS-CoV-2) spike (S) protein [DOI] 10.1007/s11030-022-10449-x PMC 바로가기
Monoclonal antibodies against S2 subunit of spike protein exhibit broad reactivity toward SARS-CoV-2 variantsArticle Published on 2022-12-222023-07-11 Journal: Journal of Biomedical Science [Category] COVID19(2023년), [키워드] B cell epitope monoclonal antibody phage display severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein [DOI] 10.1186/s12929-022-00891-2 PMC 바로가기
Evaluation of Antibody-Dependent Fc-Mediated Viral Entry, as Compared With Neutralization, in SARS-CoV-2 InfectionSARS-CoV-2 감염에서 중화와 비교한 항체 의존성 Fc 매개 바이러스 진입 평가Article Published on 2022-05-312022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Alpha antibody antibody dependent enhancement B.1.1.7 B.1.351 B.1.617.2 Beta characterization collected concern convalescent plasma coronavirus coronavirus – COVID-19 correlated Delta determine evaluated Fc-mediated virus entry functional Gamma HEK293 cell HEK293 cells IgM in vivo individuals infecting neutralization neutralization activity neutralization potency neutralization titer Neutralizing P.1 pandemic peaked plasma plasma dilution plasma IgG plasmas pseudovirus SARS-CoV-2 SARS-CoV-2 pseudovirus SARS-CoV-2 strain SARS-CoV-2 variants significantly significantly higher significantly lower spike (S) protein titers variant variant of concern viral entry virus virus entry viruses VoC waned Washington while [DOI] 10.3389/fimmu.2022.901217 PMC 바로가기 [Article Type] Article
Perspectives: SARS-CoV-2 Spike Convergent Evolution as a Guide to Explore Adaptive AdvantageArticle Published on 2022-05-272023-07-09 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), [키워드] convergent evolution mutations SARS-CoV-2 spike (S) protein virus [DOI] 10.3389/fcimb.2022.748948 PMC 바로가기
A SARS-CoV-2 Spike Receptor Binding Motif Peptide Induces Anti-Spike Antibodies in Mice andIs Recognized by COVID-19 PatientsSARS-CoV-2 스파이크 수용체 결합 모티프 펩티드는 마우스에서 스파이크 방지 항체를 유도하고 COVID-19 환자가 인식합니다Article Published on 2022-05-262022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] absence ACE2 acute respiratory syndrome Analysis angiotensin-converting enzyme 2 anti-S antibody Antigen available data benefit caused conformational coronavirus disease coronavirus SARS-CoV-2 COVID-19 COVID-19 patient domain elicit ELISA expressed Frequency Human human host cell immunized immunized animals immunized mice Infection interact Ligand means Neutralizing neutralizing Abs neutralizing function pandemic penetrate peptide peptide synthesis problems produced Protein RBD RBD domain RBM receptor Receptor binding receptor binding motif Region Research S protein SARS-CoV-2 selected spike spike (S) protein subject the antibody response the disease the S protein Treatment trimeric spike Vaccine Vaccines virus virus-neutralizing antibodies [DOI] 10.3389/fimmu.2022.879946 PMC 바로가기 [Article Type] Article
Neutralizing Monoclonal Antibodies Inhibit SARS-CoV-2 Infection through Blocking Membrane Fusion중화 단일 클론 항체는 막 융합 차단을 통해 SARS-CoV-2 감염을 억제합니다Article Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Alpha antigenic epitope Antisera blocking cell membrane collected conserved COVID-19 therapeutics Delta Effectiveness epitope epitope peptide Epitopes Epsilon exhibited fusion Gamma immunized immunodominant Infection inhibit SARS-CoV-2 inhibited membrane membrane fusion mice MOST Mutation NAb NAbs Neutralizing Neutralizing activity Neutralizing antibodies neutralizing antibody peptides Protein RBD RBD sequence RBD sequences Receptor binding Receptor binding domain reduced S protein S2 subunit SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 neutralizing antibodies SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike SARS-CoV-2 variant SARS-CoV-2 variants SARS-like coronaviruses sequence spike (S) protein the RBD the S protein the SARS-CoV-2 unique Vaccine Vaccines variants virus virus entry [DOI] 10.1128/spectrum.01814-21 PMC 바로가기 [Article Type] Article
Estimating the Neutralizing Effect and Titer Correlation of Semi-Quantitative Anti-SARS-CoV-2 Antibody Immunoassays반정량적 항SARS-CoV-2 항체 면역분석법의 중화 효과 및 역가 상관관계 추정Article Published on 2022-04-142022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 진단, 치료기술, 치료법, 치료제, [키워드] Anti-RBD IgG anti-SARS-CoV-2 antibody antibodies antibody Antibody responses antibody tests assays best Chemiluminescent assay comparable convalescent phase correlated correlation COVID-19 cut-off Effect evaluated IgG antibodies IgG antibody immunoassay infections investigated linear linear correlation neutralization test Neutralizing Neutralizing activity neutralizing antibody nucleocapsid protein nucleopcapsid (NP) protein Pearson plaque reduction neutralization Plaque reduction neutralization test PRNT Protein RBD Receptor-binding domain SARS-CoV-2 SARS-COV-2 infection semi-quantitative sensitivity serology specificity spike (S) protein Spike protein sVNT the RBD the receptor-binding domain the spike protein titer total antibodies total antibody virus neutralization test [DOI] 10.3389/fcimb.2022.822599 PMC 바로가기 [Article Type] Article
Rapid Degradation of SARS-CoV-2 Spike S Protein by A Specific Serine Protease특정 세린 프로테아제에 의한 SARS-CoV-2 스파이크 S 단백질의 빠른 분해Article Published on 2022-03-142022-09-11 Journal: Molecules [Category] SARS, 변종, [키워드] Acidic alkaline alkaline serine protease with an acidic pI (ASPNJ) Antiviral antiviral agent arginine ASP carbonyl cleave contributed COVID-19 Degradation degradation of S protein degrade experiment functional in vitro lysine macroscopic Mutation new treatment strategy peptide Peptide bond Prevent Protein purified Rapid RBD of SARS-CoV-2 S protein S1 subunit SARS-CoV-2 SARS-CoV-2 variants SARS-CoV-2 virus SDS-PAGE Serine serine protease Specific spike spike (S) protein the S protein the S1 subunit variant virus virus entry wild-type SARS-CoV-2 [DOI] 10.3390/molecules27061882 PMC 바로가기 [Article Type] Article
Cryptococcal Protease(s) and the Activation of SARS-CoV-2 Spike (S) ProteinArticle Published on 2022-01-272022-10-31 Journal: Cells [Category] COVID-19, [키워드] Cryptococcus neoformans activate biochemical cleavage site comparable cryptococcal infection Cryptococcus Efficiency fluorogenic peptide furin Infection peptide protease Protein proteolytic cleavage PRRA S protein S1 and S2 S1/S2 cleavage site S1/S2 site SARS-CoV-2 SARS-CoV-2 disease sequence spike spike (S) protein the SARS-CoV-2 unique [DOI] 10.3390/cells11030437 PMC 바로가기 [Article Type] Article