starting point – Communicable Diseases Research

Towards the development of an epitope-focused vaccine for SARS-CoV-2

Article

Published on 2022-10-262022-11-15
Journal: Vaccine [Category] COVID19(2023년), SARS, 변종, 진단,

Two Ligand-Binding Sites on SARS-CoV-2 Non-Structural Protein 1 Revealed by Fragment-Based X-ray Screening

Article

Published on 2022-10-182022-11-15
Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 치료제,

[키워드] affinity Antiviral antiviral drug applicability assays atomic resolution caused consequence Consequences conserved coronavirus CoV COVID-19 cross-binding effects Degradation drug design effective Efficiency expression fragment-based X-ray screening functional Health Host host mRNA IFN infection rate inhibitor interferon ligands limitation MERS coronaviruses mortality rate N-terminal domain non-structural protein non-structural protein 1 outbreak pandemic Pathways Protein provide Replication respiratory Revealed Safe SARS-CoV-2 Screening Site starting point Structure-based drug design unique vaccination Vaccines variety virulence virus X-ray X-ray crystallography
[DOI] 10.3390/ijms232012448 PMC 바로가기

Small-Molecule RAF265 as an Antiviral Therapy Acts against PEDV Infection

Article

Published on 2022-10-152022-11-15
Journal: Viruses [Category] COVID19(2023년), SARS, 치료제,

Systematic virtual screening in search of SARS CoV-2 inhibitors against spike glycoprotein: pharmacophore screening, molecular docking, ADMET analysis and MD simulations

Article

Published on 2022-10-012022-11-15
Journal: Molecular diversity [Category] COVID19(2023년), SARS, 치료제,

Genetic Surveillance of SARS-CoV-2 Mpro Reveals High Sequence and Structural Conservation Prior to the Introduction of Protease Inhibitor Paxlovid

Article

Published on 2022-08-302022-11-15
Journal: mBio [Category] COVID19(2023년), SARS, 변종, 치료제,

[키워드] 3CLpro acute respiratory syndrome Analysis analyzed Antiviral antiviral drug Antiviral treatment antivirals baseline binding circulating cleavage clinical response conservation conserved Contact Coronaviral Coronaviridae family coronavirus COVID-19 COVID-19 pandemic Critical database determine drug target effort Emergency use authorization enzyme escape mutation EUA Evolution expected Genetic genomic GISAID globe health emergency implication inhibitor inhibitors initiative introduced isolate isolates M pro motifs MPro Mutation Nirmatrelvir pandemic progresse Paxlovid protease purifying selection raise reference sequence Region remained residue retrieved robust SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 Mpro SARS-CoV-2 viral selective sequence Sequencing starting point Surveillance the SARS-CoV-2 the spike protein Treatment unique variants variants of SARS-CoV-2 virus widespread Wuhan-Hu-1
[DOI] 10.1128/mbio.00869-22 PMC 바로가기

Discovery of 2-(furan-2-ylmethylene)hydrazine-1-carbothioamide derivatives as novel inhibitors of SARS-CoV-2 main protease

SARS-CoV-2 주요 프로테아제의 신규 억제제로서의 2-(푸란-2-일메틸렌)히드라진-1-카르보티오아미드 유도체의 발견

Article

Published on 2022-08-052022-09-11
Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제,

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection

게놈 전체에 걸친 양방향 CRISPR 스크린은 뮤신을 SARS-CoV-2 감염을 조절하는 숙주 인자로 식별합니다

Article

Published on 2022-08-012022-09-11
Journal: Nature Genetics [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, 치료기술, 치료법, 치료제,

[키워드] ACE2 Activation acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus airway Antiviral bidirectional cause clathrin conducted coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 CRISPR CRISPR screen Critical Defense defense mechanism Epigenetic epithelial cell epithelial cells expression Factor family functional highlight Highlights Host host defense human lung human lung epithelial cells identify in vitro infected individuals Infection inflammatory signaling inhibit mechanism mild respiratory modulating molecular weight mucin mucins murine models Pathways progression provide Regulation respiratory respiratory distress Respiratory illness respiratory viruses SARS-CoV-2 SARS-CoV-2 entry factors SARS-COV-2 infection SARS-CoV-2-host interaction SARS-CoV-2-host interactions severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 starting point Symptom syndrome the SARS-CoV-2 TMPRSS2 transcriptional Transport Viral viral infection
[DOI] 10.1038/s41588-022-01131-x PMC 바로가기 [Article Type] Article

CROMATIC: Cro ss-Relationship Ma p of Cavi ti es from C oronaviruses

CHROMATIC: 코로나바이러스의 Cavi 시간 교차 관계 지도

Article

Published on 2022-06-272022-09-11
Journal: Journal of Chemical Information and Modeling [Category] COVID19(2023년), SARS, 변종,

Quercetin and luteolin are single-digit micromolar inhibitors of the SARS-CoV-2 RNA-dependent RNA polymerase

Research

Published on 2022-06-222022-10-05
Journal: Scientific Reports [Category] COVID19(2023년), SARS, 신약개발, 치료제,

Monoclonal antibodies for malaria prevention

말라리아 예방을 위한 단일클론항체

Review

Published on 2022-05-042022-09-12
Journal: Molecular therapy : the journal of the American So [Category] MERS, 말라리아, 진단,