SARS-CoV-2 viral protein ORF3A injures renal tubules by interacting with TRIM59 to induce STAT3 activationArticle Published on 2023-03-012023-07-11 Journal: Molecular therapy : the journal of the American So [Category] COVID19(2023년), [키워드] Acute kidney injury COVID-19 Inflammation NF-κB ORF3a Phosphorylation renal tubule SARS-CoV-2 STAT zebrafish [DOI] 10.1016/j.ymthe.2022.12.008 PMC 바로가기
Recent clinical findings on the role of kinase inhibitors in COVID-19 managementCOVID-19 관리에서 키나제 억제제의 역할에 대한 최근 임상 결과Review Published on 2022-10-012022-09-11 Journal: Life sciences [Category] 변종, 신약개발, 임상, 치료제, [키워드] activator affected alleviate Anti-inflammatory anti-viral effects antiviral agent Antiviral agents BTK clinical evidence Clinical finding Clinical practice clinical trial Complication complications Consequences coronavirus disease COVID-19 COVID-19 patient COVID-19 patients CRS cytokine release storm drug Efficacy glycogen synthase GSK-3 highly pathogenic inhibitor inhibitors JAK/STAT janus Janus kinase kinase Kinase inhibitor kinase inhibitors kinases management MAPK Novel coronavirus novel coronavirus disease outbreak p38 MAPK pandemic paradigm shift performed pharmacological pharmacological intervention protein kinase recent Signaling STAT therapy Transcription trials Viral load [DOI] 10.1016/j.lfs.2022.120809 PMC 바로가기 [Article Type] Review
Characterization of Selective and Potent JAK1 Inhibitors Intended for the Inhaled Treatment of AsthmaOriginal Research Published on 2022-08-312024-09-04 Journal: Drug design, development and therapy [Category] 대상포진, [키워드] AZD0449 AZD4604 Jak STAT [DOI] 10.2147/DDDT.S354291 PMC 바로가기 [Article Type] Original Research
USP22 controls type III interferon signaling and SARS-CoV-2 infection through activation of STINGUSP22는 STING의 활성화를 통해 III형 인터페론 신호 전달 및 SARS-CoV-2 감염을 제어합니다Article Published on 2022-08-062022-09-11 Journal: Cell Death & Disease [Category] SARS, 유전자 메커니즘, 치료제, [키워드] absence Activation Antiviral basal causative agent Control COVID-19 pandemic de novo Defense enzyme epithelial cells exogenous IFN expression function Host identify IFN IFN signaling IFN-stimulated gene IFN-stimulated genes IFN-λ IFNs implication interferons interferons (IFNs interferons (IFNs) intestinal epithelial cell involved ISG ISGs long-lasting Particles pattern Pattern recognition Pattern recognition receptors PRRs receptor reversed SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections secretion Signaling STAT Stat1 STING tumorigenesis Type Type III IFN Type III IFNs type III interferon USP22 viral infection viral replication [DOI] 10.1038/s41419-022-05124-w PMC 바로가기 [Article Type] Article
Nonproductive exposure of PBMCs to SARS-CoV-2 induces cell-intrinsic innate immune responsesSARS-CoV-2에 대한 PBMC의 비생산적 노출은 세포 고유의 타고난 면역 반응을 유도합니다Article Published on 2022-08-012022-09-11 Journal: Molecular Systems Biology [Category] SARS, 치료기술, [키워드] absence ACE2 receptor analyzed baseline bystander cell bystander cells Cell COVID-19 Culture Cytokines detectable Ex vivo experiment exposure to expression expression profile expression profiles healthy donor healthy donors human PBMC immune responses in vivo induce infected cell Infection innate immune response Interaction interferon interferon-stimulated gene interferon-stimulated genes interferon-stimulated genes. Invasion ISG ISGs Mild monocyte Monocytes mounted Particle Patient PBMC PBMCs physical proinflammatory cytokines respiratory tract response RT-PCR SARS-CoV SARS-CoV-2 severe COVID-19 Single-cell RNA sequencing STAT stimulate susceptibility triggered virus particle virus particles [DOI] 10.15252/msb.202210961 PMC 바로가기 [Article Type] Article
Network Pharmacology and Molecular Docking Elucidate the Underlying Pharmacological Mechanisms of the Herb Houttuynia cordata in Treating Pneumonia Caused by SARS-CoV-2네트워크 약리학 및 분자 도킹은 SARS-Cov-2로 인한 폐렴 치료에서 허브 호우 트 튜 니아 코타 타의 근본적인 약리학 적 메커니즘을 설명합니다.Article Published on 2022-07-212022-08-31 Journal: Viruses [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro ACE2 activity afzelin Analysis antiviral properties apigenin applied approach Asian caused China Combination docking DPP4 ELANE expression profiling Factor Herb herbal medicine High-throughput sequencing Houttuynia cordata HSP90AA1 IL6 ingredient integration involved Jak-STAT Japan kaempferol MAPK MAPK1 mechanism metabolite molecular molecular docking molecular dynamics Molecular dynamics simulation network network pharmacology NF-kB pharmacological pharmacological mechanism Pharmacology PI3K Pneumonia provide pulmonary infections quercetin reported required Research SARS-CoV-2 Sequencing SERPINE1 signaling pathways STAT suggested systemic level target therapeutic therapeutic effect therapeutic potential therapy treat treating [DOI] 10.3390/v14071588 PMC 바로가기 [Article Type] Article
Integrated plasma proteomic and single-cell immune signaling network signatures demarcate mild, moderate, and severe COVID-19통합 혈장 단백질체 및 단일 세포 면역 신호 네트워크 시그니처는 경증, 중등도 및 중증 COVID-19를 구분합니다.Article Published on 2022-07-192022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 임상, 진단, 치료기술, [키워드] addition approach AUC Cell clinical manifestation clinical manifestations coronavirus Coronavirus 2019 COVID-19 COVID-19 progression COVID-19 severity CyTOF determinant dysregulation examination feature hallmark identify immune Immunophenotyping Inflammatory JAK/STAT Ligand MAPK mass cytometry Mild moderate mTOR NF-κB nuclear Olink Patient patients PBMC Peripheral blood phenotype phosphosignaling response plasma plasma protein plasma proteins proteomic proteomics response reveal SARS-CoV-2 severe COVID-19 Signaling single-cell stacked generalization. STAT therapeutic target therapeutic targets Treatment uninfected [DOI] 10.1016/j.xcrm.2022.100680 PMC 바로가기 [Article Type] Article
Nucleopore Traffic Is Hindered by SARS-CoV-2 ORF6 Protein to Efficiently Suppress IFN-β and IL-6 SecretionIFN-β 및 IL-6 분비를 효율적으로 억제하기 위해 SARS-CoV-2 ORF6 단백질에 의해 핵공 이동이 방해됨Article Published on 2022-06-112022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation addition antagonistic antiviral response block cascade characterized clinical outcomes contributing to counteract Critical cytokine Cytokines cytoplasm cytoplasmic demonstrated ENCODE exacerbated Factors feature Genes Host host immune system IFN-β IL-6 immune immune evasion Infection Inflammation interferon interferon antagonist interleukin interleukin-6 MAVS MDA-5 mechanism Messenger RNA movement mRNA multifunctional NF-κB not affected novel SARS-CoV-2 virus nuclear translocation nucleus occurred ORF6 pro-inflammatory cytokine pro-inflammatory cytokines Protein reported RIG-I SARS-CoV-2 SARS-CoV-2 ORF6 protein SARS-CoV-2 virus Signaling STAT suppresse suppression the SARS-CoV-2 Traffic transcription factor transcription factors transcriptional viral infection viral pathogenesis virulence virus [DOI] 10.3390/v14061273 PMC 바로가기 [Article Type] Article
JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoidsJAK 억제제는 사구체 세포에서 COVID-19 사이토카인 유도 JAK/STAT/APOL1 신호전달 및 인간 신장 오르가노이드에서 족세포병증을 차단합니다Article Published on 2022-06-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] abundantly expressed alleles APOL1 Baricitinib best block blocked capillary carried carrier cause Cell Cell Biology cells collapse controls COVID-19 COVID-19 infection cytokine Cytokines demonstrated Endothelial cell endothelial cells expression glomerular glomerular capillaries human kidney Infection inhibitor iPS cells. JAK inhibitor jak inhibitors JAK/STAT JAK/STAT pathway JAK/STAT signaling JAK1 kidney Kidney disease knowledge majority mechanism Nephrology nephropathy Organoid organoids pathogenic Patient phenotype podocyte Podocytes Protein reduced rescued resulting risk SARS-CoV-2 Signaling STAT Support Therapeutic benefit therapeutic benefits Trigger viability [DOI] 10.1172/jci.insight.157432 PMC 바로가기 [Article Type] Article
Gene Set Enrichment Analysis Reveals That Fucoidan Induces Type I IFN Pathways in BMDC유전자 세트 농축 분석을 통해 후코이단이 BMDC에서 I형 IFN 경로를 유도한다는 사실이 밝혀졌습니다Article Published on 2022-05-272022-09-11 Journal: Nutrients [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] activate Analysis Antigen presentation Antiviral antiviral activity BMDC CD40 CD80 cytometric DEGs dendritic dendritic cell dendritic cells differentially expressed gene Differentially expressed genes differentially expressed genes (DEGs) driven by enrichment enrichment analysis Flow Flow cytometric analysis fucoidan gene set enrichment analysis gene set enrichment analysis (GSEA) greater GSEA highlighting IFN IFN-stimulated gene immune cells Inflammatory response innate immune Innate immune cells IRF ISG ISGs maturation mechanism MHCII NF-κB NLR nucleic acid pathway Pathways polysaccharide potential mechanism Prevent PRR receptor SARS-CoV-2 Signaling STAT STING sulfated surface marker TLR transcription factors transcriptional change transcriptionally Transcriptome transcriptome change treat Type type I Type I IFN type I interferon upregulated viral infections viruses [DOI] 10.3390/nu14112242 PMC 바로가기 [Article Type] Article