Feline Chronic Gingivostomatitis Diagnosis and Treatment through Transcriptomic InsightsCase Report Published on 2024-02-212024-09-05 Journal: Pathogens [Category] update2024, [키워드] Biomarkers dentistry feline gingivitis MSC stem cells stomatitis transcriptomics [DOI] 10.3390/pathogens13030192 PMC 바로가기 [Article Type] Case Report
Human ACE2 Genetic Polymorphism Affecting SARS-CoV and SARS-CoV-2 Entry into CellsArticle Published on 2022-08-312022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 acute respiratory syndrome Affect Alter analyzed bind binding Cell cells cellular entry coronavirus CoV CoVs Effect Efficiency expressing Genetic polymorphism glycoprotein HEK293T cell host cell membrane host susceptibility Human human ACE2 human Angiotensin-converting enzyme humans Infection Interaction investigated negatively affected plasma membrane Plasmid polymorphism previous study pseudotyped Pseudotyped viruses RBD RBD of SARS-CoV-2 Receptor binding domain relative infectivity reported S protein SARS CoV SARS-CoV SARS-CoV-2 severe pneumonia significantly Single nucleotide variant SNPs SNV SNVs Spike protein stomatitis Substitution suggested Support susceptibility the binding affinity the S protein the SARS-CoV-2 thought transfected with variants of concern viral entry viral surface virus virus entry virus infection viruses were infected wild-type [DOI] 10.1128/spectrum.00870-22 PMC 바로가기
Preclinical immunogenicity and efficacy of a candidate COVID-19 vaccine based on a vesicular stomatitis virus-SARS-CoV-2 chimera수포성 구내염 바이러스-SARS-CoV-2 키메라 기반 코로나19 후보 백신의 전임상 면역원성과 효능Article Published on 2022-08-012022-09-12 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] acute respiratory syndrome administration AIDS approach authority candidate vaccine chimeric coding sequence coronavirus coronavirus disease cotton Cotton rat COVID-19 COVID-19 vaccine Department develop development dose Ebola virus Efficacy evaluated glycoprotein hamster hamsters Immunity immunogenic immunogenicity Inc Inc. initiative injection intramuscular lung mucosal Mucosal vaccination nasal nasal tissue New York Part Preclinical PROTECT reduce reduced replacing Research respond SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 vaccine Sharp significantly single vaccine spike stomatitis supported Syrian hamster the SARS-CoV-2 the vaccine threat tissues Transmission USA vaccination Vaccine vaccine candidate vesicular stomatitis vesicular stomatitis virus virus virus load VSV weight loss [DOI] 10.1016/j.ebiom.2022.104203 PMC 바로가기 [Article Type] Article
rVSV-ΔG-SARS-CoV-2-S vaccine: repeated intramuscular (IM) toxicity, local tolerance, immunogenicity and biodistribution study in NZW rabbitsrVSV-ΔG-SARS-CoV-2-S 백신: NZW 토끼에서 반복되는 근육내(IM) 독성, 국소 내성, 면역원성 및 생체 분포 연구Article Published on 2022-08-012022-09-11 Journal: Archives of Toxicology [Category] COVID19(2023년), MERS, SARS, 비임상, 진단, 치료기술, [키워드] Administered animals antibody antibody levels Antibody titers Antigen assigned binding biodistribution biodistribution study body temperature body weight breath C-reactive protein change Clinical pathology Clinical signs clinical trial clinical trials correlated COVID-19 detection elicited evaluate Express followed by Gross High-dose high-dose group histopathological iliac lymph node immunogenicity inflammatory reaction injection intervals intramuscular intramuscularly Local local reactions Lymph node mesenteric lymph nodes Necrosis Neutralizing antibodies Neutralizing antibody titer neutralizing antibody titers New Nonclinical ophthalmology pathology Phase 2 platform Reactions repeated RNA Safe Safety SARS-CoV-2 SARS-CoV-2-S significant increase spleen stomatitis supported systemic the vaccine Tolerance Toxicity two group two groups Urinalysis vaccination Vaccine vaccine doses Vector-based vaccine vesicular stomatitis vesicular stomatitis virus Viremia VSV was performed [DOI] 10.1007/s00204-022-03302-5 PMC 바로가기 [Article Type] Article
Safety and immunogenicity of intramuscular, single-dose V590 (rVSV-SARS-CoV-2 Vaccine) in healthy adults: Results from a phase 1 randomised, double-blind, placebo-controlled, dose-ranging trial건강한 성인을 대상으로 한 단일 용량 V590(rVSV-SARS-CoV-2 Vaccine)의 근육 내 안전성 및 면역원성: 1상 무작위 배정, 이중 맹검, 위약 대조, 용량 범위 시험 결과Clinical Trial Published on 2022-08-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료법, [키워드] Administered administration Adults adverse event adverse events AEs anti-SARS-CoV-2 Antibody responses comparable COVID-19 COVID-19 vaccine Day dose double-blind Endpoint fatigue global pandemic headache healthy highest dose immunogenicity Inc. Injection-site pain intramuscular lower dose neutralisation neutralising antibody response Older overcome Part participant pfu Phase 1 phase 1 study Placebo placebo-controlled plaque plaque-forming unit plaque-forming units primary endpoints PRNT50 randomised receive reduction Registration reported Result Safety SARS-CoV-2 SARS-CoV-2 nucleocapsid seronegative seronegative participant seronegative participants seropositive serum Sharp spike-specific antibody response stomatitis subsidiary Trial USA V590 Vaccine vesicular stomatitis vesicular stomatitis virus vesicular stomatitis virus (VSV) virus VSV [DOI] 10.1016/j.ebiom.2022.104138 PMC 바로가기 [Article Type] Clinical Trial
BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike proteinSARS-CoV-2의 BSL2 호환 치명적인 마우스 모델 및 Spike 단백질을 표적으로 하는 치료제 평가를 위한 우려 변종Article Published on 2022-07-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 transgenic mice acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 animal model antibody both virus both viruses brains BSL-2 BSL-2 mouse model BSL2 BSL3 BST2 can be used CCL5 change competent concern conditions coronavirus COVID-19 COVID19 CXCL10 disease Disease progression drugs Encephalitis evaluate experimental therapeutics facilitate faster generate GFP glycoprotein hACE2 host-pathogen interactions in vivo increased expression Infection interferon IRF7 K18-hACE2 K18-hACE2 transgenic mice lethal infection LILRB4 lung Lungs mass vaccination mice modulate mouse model mutations Neonatal neuronal infection neurotropism pathogenicity prophylactic treatment Protein pseudotyped Pseudotyped virus Receptor binding domain replaced REPLACED BY Replication reported SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variants SARS-CoV-2 viruses SARS2 severe acute respiratory syndrome Coronavirus Spike protein stomatitis successive wave successive waves the SARS-CoV-2 the Spike the spike protein therapeutic Therapeutics transgenic transgenic mice Transmission vaccination Vaccine development variant variants of concern vesicular vesicular stomatitis vesicular stomatitis virus virulence virus VoC VSV VSV (vesicular stomatitis virus) [DOI] 10.3389/fimmu.2022.919815 PMC 바로가기 [Article Type] Article
Characterization of Immune Response Diversity in Rodents Vaccinated with a Vesicular Stomatitis Virus Vectored COVID-19 Vaccine수포성 구내염 바이러스 벡터가 적용된 COVID-19 백신을 접종한 설치류의 면역 반응 다양성 특성화Article Published on 2022-05-242022-09-12 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated acute respiratory syndrome Administered animal model animal models applied BALB/c mice candidate Cellular immune response cellular immunity challenge characterization coronavirus coronavirus disease COVID-19 COVID-19 vaccine Diversity effective Efficacy evaluated hamsters humoral immune response immune response immunization immunization routes intramuscular intranasal Neutralizing neutralizing antibody Protective protective immunity provide public health recombinant COVID-19 vaccine recombinant vesicular stomatitis virus reflect response robust rodent SARS-CoV-2 significantly higher stomatitis susceptible Syrian Golden hamsters T cell Th1 Th2 triggered Vaccine vaccine candidate vesicular vesicular stomatitis virus VSV [DOI] 10.3390/v14061127 PMC 바로가기 [Article Type] Article
Discovery and Use of Long dsRNA Mediated RNA Interference to Stimulate Antiviral Protection in Interferon Competent Mammalian Cells인터페론 유능한 포유동물 세포에서 항바이러스 보호를 자극하기 위한 긴 dsRNA 매개 RNA 간섭의 발견 및 사용Article Published on 2022-05-062022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] Antiviral Antiviral effect antiviral response antiviral responses cell line cells cellular cleaved comparable competent complementary Concentration cornerstone CoV dependent on Dicer dsRNA Evidence explanation expressing fluorescent functional gene targeting generate green fluorescent protein HCoV HCoV-229E human coronavirus human coronaviruses IFN immune defense induce inducer inhibit Interference interferons knockdown Lineage Long long dsRNA mammalian mammalian cell mammalian cells Mediated mRNA pathway platform preventing infection produced protection Protein provide required responsible retained RISC RNA RNA interference RNA-induced silencing complex RNAi RNAi pathway SARS-CoV-2 replication sequence shown significantly siRNA siRNAs stimulate stomatitis suppress therapeutic These cells threshold type I interferon vesicular stomatitis vesicular stomatitis virus viral inhibition virus VSV-GFP [DOI] 10.3389/fimmu.2022.859749 PMC 바로가기 [Article Type] Article
Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variantsSARS-CoV-2 스파이크 항원으로 과면역된 트랜스염색체 소의 인간 면역글로불린은 바이러스 변이체를 효율적으로 중화합니다Article Published on 2022-04-292022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus amino-acid anti-SARS-CoV-2 anti-SARS-CoV-2 immunoglobulin bovine convalescent coronavirus COVID-19 Deletion deletions DNA dose E484K effective Effectiveness followed by Human human immunoglobulin Human plasma Immunity immunization Immunoglobulin in vitro inhibit insect cells mAb mAbs monoclonal antibodies monoclonal antibody mutant N501Y neutralization neutralization potency neutralize Plasmid plasmid DNA polyclonal polyclonal antibodies produced purified reduce repeated respiratory resulting retained S gene S protein S variant S477N SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike antigen severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Spike protein stomatitis Substitution substitutions the SARS-CoV-2 therapeutic transchromosomic bovines Vaccines variant variants variants of concern vesicular stomatitis vesicular stomatitis virus viral variant VSV Wuhan strain [DOI] 10.1080/21645515.2021.1940652 PMC 바로가기 [Article Type] Article
Boosting of SARS-CoV-2 immunity in nonhuman primates using an oral rhabdoviral vaccine경구 랍도바이러스 백신을 사용한 비인간 영장류의 SARS-CoV-2 면역 강화Article Published on 2022-04-012022-09-12 Journal: Vaccine [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] administration cell tropism clinical clinical trials cynomolgus macaques effort G protein help immune response Immunity intramuscular Lipid nanoparticle Neutralizing antibodies oral Oral vaccine parental poorly immunogenic Rhabdovirus SARS-CoV-2 SARS-CoV-2 immunity SARS-CoV-2 neutralizing antibody SARS-CoV-2 spike glycoprotein stomatitis T cells vaccinated individual Vaccine virion virus VSV VSV. [DOI] 10.1016/j.vaccine.2021.12.063 PMC 바로가기 [Article Type] Article