Humoral response and neutralising capacity at 6 months post-vaccination against COVID-19 among institutionalised older adults in ArgentinaArticle Published on 2022-09-262022-11-15 Journal: Frontiers in Immunology [Category] SARS, 진단, [키워드] affected age aging adults Anti-spike anti-Spike IgG antibody AZD1222 B.1 BBIBP-CorV Buenos Aires Cohort Complete correlation COVID-19 COVID-19 pandemic death different time point dose elicited evaluated Evidence evidenced exhibited Gender highlighting hospitalisation humoral Humoral response IgG titer IgG titers initial management neutralising Neutralising activity Neutralising Antibodies neutralising antibodies. Older omicron pandemic participant Participants plasma sample platform provide public health resulting SARS-CoV-2 significantly higher Sputnik-V Strong vaccination vaccination schedule vaccine platform Volunteer [DOI] 10.3389/fimmu.2022.992370 PMC 바로가기
Older Adults Mount Less Durable Humoral Responses to Two Doses of COVID-19 mRNA Vaccine but Strong Initial Responses to a Third DoseArticle Published on 2022-09-212022-11-15 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, [키워드] ACE2 ACE2 displacement acute respiratory syndrome Adults age antibody concentration benefit binding binding antibodies chronic health condition chronic health conditions circulating antibody comparable coronavirus coronavirus disease COVID-19 COVID-19 mRNA vaccines COVID-19 vaccine domain dose doses exceeded functional humoral Humoral immunity Humoral response humoral responses immune immunogenicity data less magnitude mount mRNA Older Older adults omicron reached response Result SARS-CoV-2 Spike protein strain Strong Vaccine vaccine dose vaccine doses viral neutralization viral neutralization. Virus neutralization [DOI] 10.1093/infdis/jiac199 PMC 바로가기
PEDOT:PSS in Solution Form Exhibits Strong Potential in Inhibiting SARS-CoV-2 Infection of the Host Cells by Targeting Viruses and Also the Host CellsArticle Published on 2022-09-122022-11-16 Journal: Biomacromolecules [Category] SARS, 변종, [키워드] ACE2-expressing cell acute respiratory syndrome antiviral activity blocked caused Cell cells Combination coronavirus Culture cytotoxicity Effect exhibited form global pandemic high mutation rate inhibitor investigated medium Mutation Potential Prophylactic pseudovirus pseudovirus SARS-CoV-2 SARS-CoV-2 pseudovirus infection SARS-CoV-2 variant solution Spike protein Strong targeting the SARS-CoV-2 the spike protein therapeutic transcriptional transcriptomic data Transmission treated Treatment variants virus virus [DOI] 10.1021/acs.biomac.2c00271 PMC 바로가기
t6A and ms2t6A Modified Nucleosides in Serum and Urine as Strong Candidate Biomarkers of COVID-19 Infection and SeverityArticle Published on 2022-09-032022-11-15 Journal: Biomolecules [Category] SARS, 바이오마커, 변종, [키워드] addition Alter Biomarker candidate cellular RNA changes in COVID-19 COVID-19 infection COVID-19 patient COVID-19 patients elevated Extracellular Infection LC-MS modified nucleosides. nucleoside nucleosides RNA SARS-CoV-2 searched serum severity Strong symptom severity Urine variants [DOI] 10.3390/biom12091233 PMC 바로가기
Preclinical study of formulated recombinant nucleocapsid protein, the receptor binding domain of the spike protein, and truncated spike (S1) protein as vaccine candidates against COVID-19 in animal models동물 모델에서 COVID-19에 대한 백신 후보로서 제형화된 재조합 뉴클레오캡시드 단백질, 스파이크 단백질의 수용체 결합 도메인 및 절단 스파이크(S1) 단백질의 전임상 연구Article Published on 2022-09-012022-09-11 Journal: Molecular immunology [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome adjuvants alum alum adjuvant analyzed animal model antibody Antibody titers Antigen AS03 binding candidate vaccine cellular cellular immunity Cellular responses COVID-19 cytokine Cytometry cytotoxicity domain dose doses ELISA evaluated flow cytometry humoral humoral and cellular immunity IgG antibody IgG antibody titer immunization immunization program immunogenic immunogenicity injection mice Mild mild to moderate moderate N-terminal domain not neutralize nucleocapsid protein nucleoprotein pathologic preclinical study primates produced Protein protein antigens RBD Receptor binding domain Receptor-binding domain respiratory SARS-CoV-2 sera Severe acute respiratory syndrome Spike protein Strong Subunit vaccine Subunit vaccine. the spike protein Vaccine vaccine candidate virus Virus neutralization VNT was performed was recorded were used [DOI] 10.1016/j.molimm.2022.06.007 PMC 바로가기 [Article Type] Article
Contrasting Patterns in the Early Stage of SARS-CoV-2 Evolution between Humans and MinksArticle Published on 2022-09-012022-11-16 Journal: Molecular Biology and Evolution [Category] SARS, 변종, [키워드] adaptive amino acid changes analyzed change circulating deviate domain early phase Epidemic Epidemics Evolution feature Frequency Genetic genetic hitchhiking Host Human humans Infection Ka/Ks lack late phase mink Mutation mutations Neutral nonsynonymous other coronaviruses outbreak pandemic parental pattern positive Positive selection produced receptor-binding motif SARS-CoV SARS-CoV-2 selection process sequence site frequency spectrum site frequency spectrum. Stage Strong synonymous the SARS-CoV-2 the spike protein unique variant virus virus [DOI] 10.1093/molbev/msac156 PMC 바로가기
Clinical and Genomic Characterization of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Infections in mRNA Vaccinated Health Care Personnel in New York CityArticle Published on 2022-08-242022-11-16 Journal: Clinical Infectious Diseases: An Official Publicat [Category] SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome B.1.617.2 Breakthrough infection breakthrough infections Cancer center characterization circulation clade clinical Clustering Cohort coronavirus coronavirus 2 death Delta dominant domination dose Effectiveness epidemiologic feature examined finding genomic hcp healthcare personnel Hospitalization Infection infections isolate laboratory-confirmed Messenger RNA moderate mRNA New York City occurred Post-vaccine respiratory Retrospective study SARS CoV-2 SARS-CoV-2 selection of variant Spread Strong study period Vaccine vaccine effectiveness. variant WGS Whole genome sequencing [DOI] 10.1093/cid/ciab886 PMC 바로가기
Strong T-cell activation in response to COVID-19 vaccination in multiple sclerosis patients receiving B-cell depleting therapiesB 세포 고갈 요법을받는 다발성 경화증 환자에서 COVID-19 예방 접종에 대한 강력한 T 세포 활성화Article Published on 2022-08-052022-09-11 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive Adaptive immune response Adaptive immunity analyzed anti-CD20 anti-CD20 therapy antibodies antibody production B-cell binding blocking activity BNT162b2 Cellular immune response cellular response Cohort competent Complication condition controls coronavirus COVID-19 COVID-19 vaccination depleting disease driven by form forms hACE2 healthy control humoral Humoral and cellular responses IFNγ IgG antibodies IgG antibody IL-2 immunocompromised individuals Immunotherapy implication individual individuals Infection investigation mRNA mRNA-1273 mRNA-based mRNA-based vaccine multiple sclerosis no difference Ocrelizumab Patient patients proliferation RBD receiving Receptor binding domain recognizing reduced regimen relapsing respiratory rituximab SARS-CoV-2 Seroconversion seroconversion rate severe acute respiratory syndrome Coronavirus significantly significantly higher Spike protein Strong strong T-cell susceptible T-cell T-cell activation T-cell Response therapy vaccination vaccination. Vaccine design virus infection [DOI] 10.3389/fimmu.2022.926318 PMC 바로가기 [Article Type] Article
Longitudinal SARS-CoV-2 RNA wastewater monitoring across a range of scales correlates with total and regional COVID-19 burden in a well-defined urban population다양한 규모의 종방향 SARS-CoV-2 RNA 폐수 모니터링은 잘 정의된 도시 인구의 전체 및 지역 COVID-19 부담과 상관 관계가 있습니다.Article Published on 2022-07-152022-09-11 Journal: Water research [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료법, [키워드] affected analyzed approach Calgary Canada census Census data Chain Reaction city clinically collected Concentration correlated correlation Correlation analysis COVID-19 COVID-19 case COVID-19 pandemic demonstrated diagnosed effective epidemiological monitoring Epidemiology first-wave Flow individual longitudinal mechanism MONITOR N1 and N2 Neighborhoods Nucleocapsid gene Occurrence organized plant polymerase chain polymerase chain reaction Postal code processed quantitative polymerase chain reaction Region reverse transcription RNA RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA socioeconomic status Spread Strong Surveillance Treatment was performed wastewater Wastewater-based epidemiology. were used [DOI] 10.1016/j.watres.2022.118611 PMC 바로가기 [Article Type] Article
mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273청소년의 mRNA 또는 ChAd0x1 COVID-19 예방 접종은 mRNA-1273에 이어 오미크론을 계속 인식하여 강력한 항체 및 세포 반응을 유도합니다Article Published on 2022-06-022022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Adolescent antibody antibody level antibody levels Antibody Response BNT162b2 CD4+ T-cell Cell cellular response Cellular responses ChAdOx1 comprehensive analysis COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines cytokine develop dominant Donor doses dual elicit Evidence generate health condition High-risk patients IL-10 immune response immune responses immunogenic Infection measure memory Mild mRNA mRNA vaccination mRNA vaccine mRNA-1273 natural infection neuro-disabilities neutralisation titre Neutralisation titres omicron Omicron variant paediatric physical populations reactivity Recognition remained response risk robust severe disease significantly increased single vaccination Strong T-cell T-cell Response T-cell responses T-cells These data vaccination Vaccine vaccine dose vaccine. variant [DOI] 10.3389/fimmu.2022.882515 PMC 바로가기 [Article Type] Article