Analysis of Virus-Specific B Cell Epitopes Reveals Extensive Antigen Degradation Prior to RecognitionArticle Published on 2024-06-212024-09-05 Journal: Cells [Category] update2024, [키워드] antibody B cell epitope linear B cell epitope Structural analysis virus [DOI] 10.3390/cells13131076 PMC 바로가기 [Article Type] Article
An in vitro experimental pipeline to characterize the epitope of a SARS-CoV-2 neutralizing antibodyResearch Article Published on 2024-01-062024-09-05 Journal: mBio [Category] update2024, [키워드] cryo-EM epitope mapping neutralizing antibody SARS-CoV-2 Structural analysis Viral resistance [DOI] 10.1128/mbio.02477-23 PMC 바로가기 [Article Type] Research Article
Profiles of global mutations in the human intercellular adhesion molecule-1 (ICAM-1) shed light on population-specific malaria susceptibility인간 세포 간 부착 분자 -1 (ICAM-1)에서 글로벌 돌연변이의 프로파일은 인구-특이 적 말라리아 감수성에 빛을 비추다Article Published on 2023-12-132024-07-29 Journal: BMC Genomics [Category] 말라리아, [키워드] ICAM-1 malaria PfEMP1 SNP Structural analysis [DOI] 10.1186/s12864-023-09846-9 PMC 바로가기
Computational Modelling, Functional Characterization and Molecular Docking to Lead Compounds of Bordetella pertussis Diaminopimelate Epimerasearticle Published on 2023-11-302024-09-01 Journal: Applied Biochemistry and Biotechnology [Category] 백일해, [키워드] Diaminopimelate epimerase docking Protein interaction network Structural analysis [Article Type] article
Distinct In Vitro and In Vivo Neutralization Profiles of Monoclonal Antibodies Elicited by the Receptor Binding Domain of the Ancestral SARS-CoV-2Article Published on 2023-04-262024-09-05 Journal: Journal of medical virology [Category] update2024, [키워드] cross-neutralization neutralizing antibody RBD-reactive antibody receptor binding domain (RBD) SARS-CoV-2 Structural analysis [DOI] 10.1002/jmv.28673 PMC 바로가기 [Article Type] Article
Novel bispecific human antibody platform specifically targeting a fully open spike conformation potently neutralizes multiple SARS-CoV-2 variantsArticle Published on 2023-03-022024-09-05 Journal: Antiviral Research [Category] update2024, [키워드] bispecific antibody cryo-EM Immunoglobulin G4 phage display SARS-CoV-2 variants Structural analysis [DOI] 10.1016/j.antiviral.2023.105576 PMC 바로가기 [Article Type] Article
Modeling studies on the role of vitamins B1 (thiamin), B3 (nicotinamide), B6 (pyridoxamine), and caffeine as potential leads for the drug design against COVID-19Article Published on 2022-11-072022-11-15 Journal: Journal of molecular modeling [Category] SARS, 신약개발, 치료제, [키워드] ACE-2 adopted Antiviral antiviral activity applied approach binding pocket binding site caffeine Cell Characteristics chemical property Compound COVID-19 COVID-19 pandemic docking domain dosage drug design effective evaluate function impair Interaction Invasion lack mechanism modeling molecular molecular dynamic simulations Neutral nicotinamide potential mechanism Protein pyridoxamine Safe SARS-CoV-2 selected Side effects Structural analysis Structure the SARS-CoV-2 the Spike thiamin Toxicity Vitamin Vitamin B. [DOI] 10.1007/s00894-022-05356-9 PMC 바로가기
An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challengesArticle Published on 2022-11-012022-11-15 Journal: Biochemical pharmacology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] addition Antiviral antiviral drug causative pathogen complex Coronaviruses COVID-19 COVID-19 pandemic effective Effectiveness enzyme highest human cell identification Infection inhibitor inhibitors Interaction promise RdRP Replication Research RNA-dependent RNA polymerase SARS-CoV-2 Structural analysis therapeutic drug transmissible variant Viral RNA [DOI] 10.1016/j.bcp.2022.115279 PMC 바로가기
Elucidation of the inhibitory activity of ivermectin with host nuclear importin α and several SARS-CoV-2 targetsArticle Published on 2022-11-012022-11-15 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] 3CL pro 3CLpro acting antiviral activity approach binding binding free energy complex COVID-19 dimeric docked complexes docking explained FDA-approved drug FIVE heterodimeric Host in vitro activity inhibit inhibitor inhibitory activity Ivermectin MD simulation molecular molecular docking Molecular dynamics simulation molecular mechanism nuclear previous study protease Proteins reached Replication responsible SARS-CoV-2 SARS-CoV-2 replication shown Structural analysis structural property target translocation variety virus with COVID-19 [DOI] 10.1080/07391102.2021.1911857 PMC 바로가기
Mutational dynamics across VOCs in International travellers and Community transmission underscores importance of Spike-ACE2 interaction국제 여행자의 VOC와 지역 사회 전파에 걸친 돌연변이 역학은 Spike-ACE2 상호 작용의 중요성을 강조합니다.Article Published on 2022-09-012022-09-11 Journal: Microbiological research [Category] COVID19(2023년), SARS, 변종, [키워드] A570D Alpha analysed B.1.617.2 binding binding affinity change Community community transmission comparable COVID-19 case COVID-19 pandemic D1118H D950N Delta demonstrated different time point different time points disequilibrium early phase emergence Evolution functional G142D Genomic surveillance India Interaction International investigated L452R Lineage linkage Linkage disequilibrium Mutation mutation analysis mutations N501Y notable omicron ORF1 ORF1ab overlap predict raised S982A SARS-CoV-2 selective spike spike mutations spike-ACE2 Spread Structural analysis Transmissibility Transmission transmission pattern unique vaccination variants variants of concern VoC VOCs [DOI] 10.1016/j.micres.2022.127099 PMC 바로가기 [Article Type] Article