Multiscale analysis of pangenomes enables improved representation of genomic diversity for repetitive and clinically relevant genesarticle Published on 2023-06-262024-09-05 Journal: Nature Methods [Category] update2024, [키워드] Genome assembly algorithms Software Structural variation [DOI] 10.1038/s41592-023-01914-y PMC 바로가기 [Article Type] article
A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antiviralsSARS-CoV-2 항바이러스제로서의 알데히드 기반 트리펩티딜 주요 프로테아제 억제제의 다각적 평가Article Published on 2022-10-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 293T cell 293T cells active site aldehyde Amino acid amino acids Antiviral antiviral potency binding carbon cellular complexes conducted covalent inhibitors COVID-19 crystal structure cysteine cytotoxicity develop enzyme exhibited expressed flexible high potency in vitro inhibit inhibitor inhibitors interact low potency M pro main protease N-terminal pathogen Previous studies previous study Pro protease Protease inhibitor residue residues SARS-CoV-2 selected Structural variation structures tolerable Toxicity Treatment treatment of COVID-19 Tripeptides. unnatural Variation X-ray [DOI] 10.1016/j.ejmech.2022.114570 PMC 바로가기 [Article Type] Article
The third international hackathon for applying insights into large-scale genomic composition to use cases in a wide range of organismsArticle Published on 2022-05-162022-11-15 Journal: F1000Research [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 진단, [키워드] Annual Cancer clinically college country COVID-19 genomic genotyping hackathon International k-mer long-reads Medicine NGS nine organism participated Research SARS-CoV-2 variants sequence Structural variant structural variants Structural variation SVs Tomatoes Viral integration [DOI] 10.12688/f1000research.110194.1 PMC 바로가기
Conserved Pattern and Potential Role of Recurrent Deletions in SARS-CoV-2 EvolutionSARS-CoV-2 진화에서 보존된 패턴 및 반복 삭제의 잠재적 역할Article Published on 2022-04-272022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] adaptive adaptive evolution addition association binding site Combination coronavirus COVID-19 deleted Deletion deletions described disease distribution Epidemic Evidence Evolution functions genome structure greater Host human host indicated insertion insertions integration means Mutation N-terminal domain Neutralizing antibodies NSP6 nucleotide nucleotide change occurred pattern Potential Prevention and control Previous studies proliferation Protein RDRs Receptor binding domain Recurrent recurrent deletion Region regions reported role SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes SARS-related coronavirus SARS-related coronaviruses single nucleotide Spike protein Strains Structural variation structural variation. structural variations the spike protein the WHO unique Vaccine development variant variants variants of concern variants of interest Variation Viral viral genome virus Virus evolution viruses VoC whole genome worldwide pandemic Δ144 Δ69-70 [DOI] 10.1128/spectrum.02191-21 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Pandemic Tracing in Italy Highlights Lineages with Mutational Burden in Growing Subsets이탈리아의 SARS-CoV-2 전염병 추적, 증가하는 하위 집합에서 돌연변이 부담이 있는 계보 강조Article Published on 2022-04-092022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Amino acid amino acid change analysed Analysis appearance burden clades country COVID-19 pandemic database detect develop Evolution genomic Helicase help Italian patient Italian patients Italy management methyltransferase modulation MONITOR mutated Nsp12 Nsp3 nsp4 NSP6 ORF1ab ORF3a ORF8 pandemic Positive selection RdRP SARS-CoV-2 selection pressure Spike proteins Spread spreading Structural variation subpopulation tracing trees variant variant of concern (VOC) variants Viral proteins viral sequence viral sequences viral variant viral variants tracing. virus variant virus variants VoC [DOI] 10.3390/ijms23084155 PMC 바로가기 [Article Type] Article
Exposing structural variations in SARS-CoV-2 evolutionSARS-CoV-2 진화의 구조적 변이 노출Article Published on 2021-11-112022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, [키워드] ACE2 acute disease Affect affinity aligned Alpha Alpha variant Analysis B.1.1.7 B.1.617.2 conformational change conformations contributed coronavirus Course Critical delta variant disease effective Effectiveness Evolution function human cells integration lack Lineage Lineage B.1.1.7 Mutation mutations Physicochemical properties physicochemical property physiochemical property Protein protein sequence protein structure residue SARS-CoV SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 variants Spike protein Structural analysis structural biology Structural variation structural variations Structure structures the SARS-CoV-2 Vaccine variant Viral viral infection virus Virus evolution [DOI] 10.1038/s41598-021-01650-3 PMC 바로가기 [Article Type] Article
Dominant clade‐featured SARS‐CoV‐2 co‐occurring mutations reveal plausible epistasis: An in silico based hypothetical modelResearch Article Published on 2021-11-012022-10-04 Journal: Journal of medical virology [Category] MERS, SARS, 변종, [키워드] accelerate acute respiratory syndrome Affect Analysis binding circulating clade clades co‐occurring mutations coronavirus COVID‐19 decrease docking dominant Effect Efficiency eight evade event explain favor fitness flexible help hypothetical Immunity in silico in silico Approach infection paradox Interaction interactions modulate molecular MOST mutant Mutation mutations N protein nucleocapsid ORF3a P323L phenotypic effect polymerase prevalent Prospective Study Protein Q57H RdRP Replication retrospective RNA RNA stability SARS‐CoV‐2 SARS‐CoV‐2 sentinel significantly increased silent spike mutation stability Structural variation Superior translational Transmission variant viral replication virulence virus [DOI] 10.1002/jmv.27416 PMC 바로가기 [Article Type] Research Article
Genomic Variations in the Structural Proteins of SARS-CoV-2 and Their Deleterious Impact on Pathogenesis: A Comparative Genomics ApproachSARS-CoV-2 구조 단백질의 게놈 변이와 발병에 미치는 해로운 영향: 비교 게놈 접근Cellular and Infection Microbiology Published on 2021-10-132022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 유전자 메커니즘, 치료법, [키워드] (RdRp acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 Affect Analysis association Comparative Comparative genomics coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 creating envelope Enzymes failure functional consequence Genomics Health Impact Infection M pro mechanism membrane mutated Mutation nucleocapsid Pathogenesis performed protease Protein RdRP Replication respiratory rising RNA-dependent RNA polymerase S protein SARS-CoV-2 SARS-CoV-2 mutations SARS-CoV-2 pathogenesis selected sequence Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 single amino acid substitutions small molecule structural protein structural proteins Structural variation structural variations structure-function Surface glycoprotein therapeutic approaches Therapeutic strategies Variation [DOI] 10.3389/fcimb.2021.765039 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
COVID-19: Impact on linguistic and genetic isolates of IndiaCOVID-19: 인도의 언어 및 유전적 분리에 대한 영향Brief Communication Published on 2021-10-112022-09-12 Journal: Genes and Immunity [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] affected analysed Asia Brazil Community coronavirus SARS-CoV-2 COVID-19 ethnic group extreme General population genetic isolate genomic region greater group homozygosity homozygous Impact impacted increase India Infectious disease Isolation knowledge management pandemic Population rapid expansion reached reported risk Sery shown South South Asian Structural variation suggested susceptibility Till viral infection [DOI] 10.1038/s41435-021-00150-8 PMC 바로가기 [Article Type] Brief Communication
Characterizing the genomic variation and population dynamics of Plasmodium falciparum malaria parasites in and around Lake Victoria, Kenya케냐 빅토리아 호수 안팎에서 Plasmodium falciparum malaria 기생충의 게놈 변화와 인구 역학 특성Article Published on 2021-10-062022-10-04 Journal: Scientific Reports [Category] 말라리아, 바이오마커, [키워드] African analyses Analysis Baseline assessment Biomarker clearance Cluster combination therapy contribute drug resistance East Efficacy Epidemiology Frequency genetic data genetic diversity genomic genomic variation Genomics Illumina isolate Kenya Lake Lake Victoria lineages malaria Mutation P. falciparum parasite Plasmodium falciparum Population populations provide Region Sequencing Structural variation Transmission WGS [DOI] 10.1038/s41598-021-99192-1 PMC 바로가기 [Article Type] Article