Structure-function analysis for the development of peptide inhibitors for a Gram-positive quorum sensing systemarticle Published on 2022-06-302024-09-01 Journal: Molecular Microbiology [Category] 폐렴구균 감염증, [키워드] inhibitor design quorum sensing Rgg transcriptional regulators Streptococcus pneumoniae structure-function [Article Type] article
Identification of Aloe-derived natural products as prospective lead scaffolds for SARS-CoV-2 main protease (M pro) inhibitorsSARS-CoV-2 주요 프로테아제(M pro) 억제제에 대한 전향적 납 지지체로서의 알로에 유래 천연물 식별Article Published on 2022-06-152022-09-11 Journal: Bioorganic & medicinal chemistry letters [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] 3CL(pro) active site Aloe aloeresin D. Aloesin Analysis Antiviral approval binding energy catalytic caused Compound COVID-19 pandemic death demonstrated dose response curve dose response curves drug target effort enzyme FIVE Follow-up HCV Hill HIV identification identify in vitro Infection inhibitor inhibitors kinetic knowledge M pro M(pro) molecular molecular docking studies Molecular docking study natural natural products new SARS-CoV-2 offer protease Protease inhibitor protease inhibitors retrieved SARS-CoV-2 SARS-CoV-2 main protease SARS-CoV-2 variants screened small molecule structure-function TCID Therapies vaccination variants viruses [DOI] 10.1016/j.bmcl.2022.128732 PMC 바로가기 [Article Type] Article
Newly Emerged Antiviral Strategies for SARS-CoV-2: From Deciphering Viral Protein Structural Function to the Development of Vaccines, Antibodies, and Small MoleculesSARS-CoV-2에 대한 새로 등장한 항바이러스 전략: 바이러스 단백질 구조 기능 해독에서 백신, 항체 및 소분자 개발까지Review Published on 2022-05-292022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis antibody antibody cocktail antibody treatment Antiviral caused chemical compounds clustered regularly interspaced short palindromic repeats compounds contribute coronavirus coronavirus disease Coronavirus disease 2019 correlation COVID-19 COVID-19 infection CRISPR development disease pathogenesis DNA dual exploration focus function functional Health Health crisis host cells inactive Infection inhibitors life cycle molecule monoclonal antibodies monoclonal antibody mRNA nonstructural proteins palindromic repeat Particles peptide-based Protein protein-based vaccine Protein-based vaccines Proteins provide research findings respiratory RNA vaccines SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 genome severe acute respiratory syndrome Coronavirus single-stranded Strategy structural proteins structure-function systematic review target targeted therapy targets the SARS-CoV-2 genome therapeutic option Therapeutic strategies therapy Treatment Vaccine Vaccine development Vaccines Viral viral life cycle Viral protein Viral proteins viral replication virus [DOI] 10.3390/ijms23116083 PMC 바로가기 [Article Type] Review
Developing and validating a multivariable prediction model which predicts progression of intermediate to late age-related macular degeneration—the PINNACLE trial protocol Research Published on 2022-05-252022-10-05 Journal: Eye (London, England) [Category] 바이오마커, 임상, [키워드] AMD approach Biomarker Biomarkers central vision Characteristics collected correlation correlations dataset Deterioration Developing Disease progression endpoints eye feature Follow-up genotyping healthy controls identify imaging Imaging tests include individuals intermediate marker multivariable optical Optical coherence tomography outcome Patient patient data Population predict Predictive predictor Primary outcome progression Prospective Study recent recruited repeated retinal imaging retrospective retrospective cohort risk risk factor ROC curves secondary Sensitivity and specificity Stage statistical structure-function Switzerland Teaching tomography trial protocol Trigger UK biobank university utility visual function [DOI] 10.1038/s41433-022-02097-0 [Article Type] Research
The Multifaceted Biology of PCSK9PCSK9의 다면적 생물학Review Published on 2022-05-122022-09-11 Journal: Endocrine reviews [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] 17β-estradiol added alternative analyses binding biological function Biological functions Biology C-terminal Cancer cancer/metastases catalytic domain CD8+ T cells Cell cell surface cellular Characteristics cholesterol circulating Critical cytosolic Dengue domain downregulation ENhance female histocompatibility complex hypercholesterolemia immune Immunotherapy inhibitor LDL LDLR liver low-density Low-density lipoprotein Lysosomes major histocompatibility complex major histocompatibility complex I mechanism membrane-bound Metastasis MHC-I mice modulation monoclonal antibody PCSK9 Protein recent receptor reduce Regulation RNA Safe SARS-CoV-2 secreted Sepsis Septic shock Small interfering RNA sorting statins structure-function T cells T-cell receptor vascular inflammation viral infection viral infections β-cells β-cells. [DOI] 10.1210/endrev/bnab035 PMC 바로가기 [Article Type] Review
Are There Hidden Genes in DNA/RNA Vaccines?Immunology Published on 2022-02-082022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] Accessory genes administration antigenic bioinformatics clinical outcomes codon optimization connection contribute death DNA and RNA DNA vaccine Effects examined highlight inactivated information Moderna mRNA-1273 vaccine morbidity Mortality mRNA vaccine offer Open reading frame ORF ORF-Sh ORF2b ORFs overlap overlapping Pain peptides positive predicted produced Protein Proteins reported resources respiratory RNA vaccine SARS-CoV-2 SARS-CoV-2 protein selected sequence shown Spike protein structure-function the spike protein translation Treatment utility vaccination vaccination rate Vaccine vaccine candidate Vaccine design Vaccine development Vaccines virus wild-type [DOI] 10.3389/fimmu.2022.801915 PMC 바로가기 [Article Type] Immunology
Alu RNA Structural Features Modulate Immune Cell Activation and A-to-I Editing of Alu RNAs Is Diminished in Human Inflammatory Bowel DiseaseImmunology Published on 2022-01-202022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, [키워드] A-to-I editing activate Altering Alu Alu RNA Analysis Autoimmune disease biological activity Cell Consequences COVID-19 Deamination Degradation demonstrated diminished disrupt double-stranded RNA dsRNA dsRNAs element form Human human disease include increase inflammatory bowel diseases Influenza inhibit innate immune activation innate immune response Inosine IRF IRF responses leukocyte multiple sclerosis NF-kB NF-kB responses nuclear nucleotide sequence Prevent retrotransposon RIG-I RNA RNA binding proteins RNAs SINE stimulate structure-function therapeutic potential transcriptional activity viral disease widespread [DOI] 10.3389/fimmu.2022.818023 PMC 바로가기 [Article Type] Immunology
The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variantsSARS-CoV-2 베타에 대한 항체 반응은 다른 변이체와의 항원 거리를 강조합니다Article Published on 2022-01-122022-09-10 Journal: Cell Host & Microbe [Category] MERS, SARS, 변종, 진단, [키워드] Abstract Alter Analysis antibody Antibody Response antigenic antigenic structure Beta Beta variant binding conserved COVID-19 Delta E484K epitope escape Express immune responses include individual infected with SARS-CoV-2 K417N mAb mAbs multiple mutation multiple mutations mutated Mutation N-terminal domain N501Y neutralization neutralize Neutralizing Neutralizing antibodies neutralizing antibody NTD other variant pandemic Patient performed RBD Receptor-binding domain Recognition recognize residue residues SARS-CoV-1 SARS-CoV-1 and -2 SARS-CoV-2 SARS-CoV-2 strain separated sequence serum Spike protein Structure structure-function the receptor-binding domain the SARS-CoV-2 the spike protein Vaccine Vaccine-induced immunity variant variants of SARS-CoV-2 viruses [DOI] 10.1016/j.chom.2021.11.013 PMC 바로가기 [Article Type] Article
Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2SARS-COV-2에 대한 항 -RBD 인간 단일 클론 항체의 구조 및 치료 가능성Research Paper Published on 2022-01-012022-09-01 Journal: Theranostics [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] In vitro and in vivo function abrogated ACE2 Analysis anti-RBD Anti-RBD antibody anti-receptor-binding domain antibodies antibody antibody cocktail Antibody-antigen complex attenuate B.1.1.7 B.1.351 B.1.617.2 binding cocktail convalescent patient Convalescent patients COVID-19 Cryo-electron microscopy Crystallography curtail dissect effective Efficacy electron microscopy epitope Epitopes evaluate feature Formulation hamster hamsters Hospitalization Human monoclonal antibody in vitro in vivo Infection leads lung viral load mechanism mechanism of action monoclonal antibodies monoclonal antibody Mutation neutralization Neutralizing neutralizing monoclonal antibodies non-overlapping epitope non-overlapping epitopes patients with SARS-CoV-2 Prevent Prophylactic pulmonary inflammation RBD Receptor-binding domain epitope reduce reported residue reveal SARS-CoV-2 SARS-COV-2 infection shown somatic mutations Structural analysis Structure structure-function subsequent Support the RBD therapeutic therapeutic potential unique variable region variant variants variants of concern Viral viral RBD viral shedding virus weight loss wild type [DOI] 10.7150/thno.65563 PMC 바로가기 [Article Type] Research Paper
Epitope profiling using computational structural modelling demonstrated on coronavirus-binding antibodies코로나바이러스 결합 항체에서 시연된 컴퓨터 구조 모델링을 사용한 에피토프 프로파일링Research Article Published on 2021-12-132022-09-12 Journal: PLoS Computational Biology [Category] SARS, 진단, [키워드] 3D structure Algorithm Analysis antibodies antibody Antibody therapeutics approach approaches binding binding site Cluster Clustering complementary computational method conserved convergent evolution coronavirus database defined demonstrated detect domains engage epitope Epitopes Evolution experiment functional Genetic greater high accuracy identify identifying immune response immune responses immune system indicate Laboratory Lineage lineages molecular Mutation pathogen Pathogens population immunity predicted property sequence Space Specificities Strains Structure structure-function suggested therapeutic while yielding [DOI] 10.1371/journal.pcbi.1009675 PMC 바로가기 [Article Type] Research Article