Use of preventive measures, beliefs and information received about COVID-19 and their effects on mental health, in two stages of the pandemic in ColombiaObservational Study Published on 2022-12-012022-10-04 Journal: Annals of Medicine [Category] COVID19(2023년), SARS, 임상, [키워드] age Better caused COVID-19 COVID-19 pandemic cross-sectional distress Effect GHQ-12 greater Health health system Healthcare professional IMPROVE individual information knowledge less media Mental mental health official pandemic participant performed physical Prevent preventive measure preventive measures professionals promoted Psychological distress questionnaire recommendation reducing social media sociodemographic data Spain Stage structures was used women [DOI] 10.1080/07853890.2022.2109057 PMC 바로가기 [Article Type] Observational Study
Exploring the anti-SARS-CoV-2 main protease potential of FDA approved marine drugs using integrated machine learning templates as predictive toolsArticle Published on 2022-11-012022-11-15 Journal: International journal of biological macromolecules [Category] SARS, 신약개발, 치료제, [키워드] activity Activity atlas model Activity cliff Algorithm anti-SARS-CoV-2 approved Atla Biological camostat Compound COVID-19 COVID-19 pandemic Cresset data set docked drug drugs effective FDA field Field template FIVE flare group Holichondrin B inactive macromolecules Marine drugs. nafamostat outbreak Predictive protease Protein remained Repurposed drug responsible Safe SARS-CoV-2 Structure structures [DOI] 10.1016/j.ijbiomac.2022.09.086 PMC 바로가기
A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antiviralsSARS-CoV-2 항바이러스제로서의 알데히드 기반 트리펩티딜 주요 프로테아제 억제제의 다각적 평가Article Published on 2022-10-052022-09-11 Journal: European journal of medicinal chemistry [Category] COVID19(2023년), SARS, 치료제, [키워드] 293T cell 293T cells active site aldehyde Amino acid amino acids Antiviral antiviral potency binding carbon cellular complexes conducted covalent inhibitors COVID-19 crystal structure cysteine cytotoxicity develop enzyme exhibited expressed flexible high potency in vitro inhibit inhibitor inhibitors interact low potency M pro main protease N-terminal pathogen Previous studies previous study Pro protease Protease inhibitor residue residues SARS-CoV-2 selected Structural variation structures tolerable Toxicity Treatment treatment of COVID-19 Tripeptides. unnatural Variation X-ray [DOI] 10.1016/j.ejmech.2022.114570 PMC 바로가기 [Article Type] Article
Prepandemic Alzheimer Disease Biomarkers and Anxious-Depressive Symptoms During the COVID-19 Confinement in Cognitively Unimpaired AdultsArticle Published on 2022-10-042022-11-15 Journal: Neurology [Category] 바이오마커, [키워드] 95% CI accelerate Acidic adjust age Alzheimer disease analyses Analysis association Biomarker Biomarkers change changes Clinical prognosis Clinicians Cohort cortical COVID-19 CSF Disease progression driven by expressed family greater HADS Identifier IL-6 Increased independent interleukin-6 investigated Linear regression model majority marker medication MRI multivariable myeloid cell Neuroinflammation Neuropsychiatric Older pandemic participant Participants pathophysiology performed pet protein levels receptor retrospective risk scale Sex smoking Sociodemographic factor Stress stressors structures subset Symptom tested triggering variable women [DOI] 10.1212/WNL.0000000000200948 PMC 바로가기
Promising natural products against SARS-CoV-2: Structure, function, and clinical trialsArticle Published on 2022-10-012022-11-15 Journal: Phytotherapy research : PTR [Category] COVID19(2023년), SARS, 치료제, [키워드] 3CLpro ACE2 activity acute respiratory syndrome addition analyzed antiinflammatory antivirals assessments Breakthrough infection caused clinical trial clinical trials coronavirus Coronaviruses COVID-19 Critical drug drug interaction drugs Effect effective enhancer Health immune Improvements inhibitory effect mechanism Mutation natural products Protein RdRP Research SARS-CoV-2 shown Spread Structure structures Vaccine virus Virus Disease [DOI] 10.1002/ptr.7580 PMC 바로가기
SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in miceArticle Published on 2022-09-282022-11-15 Journal: Science Translational Medicine [Category] SARS, 치료제, [키워드] acute respiratory distress acute respiratory syndrome alveolar Antiviral cells chronic disease chronic inflammation clinical recovery collagen composed coronavirus coronavirus disease COVID-19 develop disease severity dysfunction dysregulated EIDD-2801 epithelial fibroblasts fibrosis histologic finding humans identify Immune cell individual Intervention lack lesion longitudinal lung abnormality lymphoid mice mouse-adapted SARS-CoV-2 murine model Nintedanib PASC Pathogenesis pathway Population proliferative provide pulmonary disease reduced regions SARS-CoV-2 SARS-COV-2 infection structures subpleural subset syndrome tissue samples transcriptional virus clearance [DOI] 10.1126/scitranslmed.abo5070 PMC 바로가기
Cross-GWAS coherence test at the gene and pathway levelArticle Published on 2022-09-262022-11-16 Journal: PLoS Computational Biology [Category] 변종, [키워드] 25OHD affecting Algorithm analyses Analysis approach association bone structure calculated Cell Chemokine receptor coefficients concentrations correlated cumulative datapoint detect distribution Effect effect size expression genetic link Genetic variant Genome-wide association study GWAS immune response independent integrin linear combination medication pathway Pathways positive Precision rheumatoid arthritis serum calcium severity of COVID-19 structures traits utility [DOI] 10.1371/journal.pcbi.1010517 PMC 바로가기
Discovery of 2-thiobenzimidazoles as noncovalent inhibitors of SARS-CoV-2 main proteaseSARS-CoV-2 주요 프로테아제의 비공유 억제제로서의 2-티오벤즈이미다졸의 발견Article Published on 2022-09-152022-09-11 Journal: Bioorganic & medicinal chemistry letters [Category] COVID19(2023년), SARS, 치료제, [키워드] Analysis antiviral agent Antiviral agents catalytic site conserved coronavirus antivirals COVID-19 pandemic docking effort in silico inhibitor inhibitors of SARS-CoV-2 inhibitory activity M pro Outbreaks predict predicted protease proteolytic protocol representing SARS-CoV-2 strain structures subset survival synthesis unique Virtual screening Zinc [DOI] 10.1016/j.bmcl.2022.128867 PMC 바로가기 [Article Type] Article
Assessing COVID-19 vaccination strategies in varied demographics using an individual-based modelArticle Published on 2022-09-152022-11-15 Journal: Frontiers in Public Health [Category] SARS, 변종, 치료기술, 치료제, [키워드] age agent-based model (ABM) applied Assessing asymptomatic infections booster doses Characteristics Contact COVID COVID- 19 COVID-19 COVID-19 vaccination COVID-19 vaccine demographics distribution distributions Effectiveness Efficiency help Hospitalization household size individual individual-base model Infection infection rate Intervention New non-pharmaceutical interventions (NPIs) NPI NPIs outbreak parameter Prevent Probability reproductive responses against SARS-CoV-2 severe disease structures subpopulation symptomatic Total unique vaccinate vaccination Vaccination strategies Vaccination strategy variants variants of SARS-CoV-2 [DOI] 10.3389/fpubh.2022.966756 PMC 바로가기
Structural- and Site-Specific N- Glycosylation Characterization of COVID-19 Virus Spike with StrucGPArticle Published on 2022-09-132022-11-15 Journal: Analytical Chemistry [Category] SARS, 치료기술, [키워드] addition Algorithm analyzed characterization COVID-19 COVID-19 virus glycan glycosylation Infection Mannose 6-phosphate mapped motif Previous studies previous study Protein residues SARS-CoV-2 Sequencing spike Structure structures Support the S protein trimer [DOI] 10.1021/acs.analchem.2c02265 PMC 바로가기