A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant Simulations Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
Rapid detection of SARS-CoV-2 variants of concern by single nucleotide polymorphism genotyping using TaqMan assaysArticle Published on 2022-12-012022-11-15 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] 95% CI Accuracy acute respiratory syndrome approach B.1.1.7 B.1.526 clinical setting Concordance coronavirus coronavirus disease 19 Coronavirus disease 19 (COVID-19) E484K evaluated genotyping mutations N501Y nasopharyngeal Negative predictive value New York City nonsynonymous patient population polymorphism positive positive sample predicted ranged Rapid Real-time reverse-transcription PCR residual RT-qPCR SARS-CoV-2 SARS-CoV-2 testing SARS-CoV-2 variant sensitivity Sequencing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) significantly lower single nucleotide specificity Spike protein submitted subset TaqMan TaqMan assay Thermofisher variant variants variants of concern were used WGS whole genome [DOI] 10.1016/j.diagmicrobio.2022.115789 PMC 바로가기
The heterogeneous mixing model of COVID-19 with interventionsArticle Published on 2022-11-212022-11-16 Journal: Journal of theoretical biology [Category] 변종, [키워드] Admission age analyzed Breakthrough infection caused China conducted Control Control reproduction number Coverage COVID-19 COVID-19 transmission death effective Effectiveness Epidemic evaluate Future group heterogeneity heterogeneous Heterogeneous mixing Infection Intervention manuscript measure mechanism mutant strain Mutant strains Prevent Prevent infection preventing infection reduce Reproduction number stability submitted Transmission vaccination Vaccination strategies Vaccination strategy Vaccine Vaccines [DOI] 10.1016/j.jtbi.2022.111258 PMC 바로가기
A subunit vaccine candidate based on the Spike protein of SARS-CoV-2 prevents infectious virus shedding in catsSARS-CoV-2의 스파이크 단백질을 기반으로 하는 서브유닛 백신 후보는 고양이의 감염성 바이러스 발산을 방지합니다Article Published on 2022-11-012022-09-11 Journal: Research in veterinary science [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] affected cats demonstrated described effective human infection Infection Infectious virus Neutralizing antibody response occurred Oropharyngeal Population Prevent preventive measure preventive measures produced Protein rectal swab SARS-CoV-2 SARS-CoV-2 virus spike Spike protein submitted subunit Subunit vaccine susceptible the disease the SARS-CoV-2 virus the Spike Transmission Trial triggered vaccination Vaccine vaccine candidate Viral viral infection virus [DOI] 10.1016/j.rvsc.2022.05.003 PMC 바로가기 [Article Type] Article
Towards Covid-19 TMPRSS2 enzyme inhibitors and antimicrobial agents: Synthesis, antimicrobial potency, molecular docking, and drug-likeness prediction of thiadiazole-triazole hybridsResearch article Published on 2022-11-012022-10-05 Journal: Journal of Molecular Structure [Category] 치료제, [키워드] 1 2 3 3-Triazoles 4-Thiadiazole analogue antimicrobial activity Bacillus subtilis binding affinity Candida albican candidate chalcone chloride Compound COVID-19 drug-likeness enzyme Escherichia coli exhibited FIVE Hydrazonoyl halides identify in silico in vitro inhibitor molecular docking pathogen Prevent proliferation Pseudomonas aeruginosa screened Staphylococcus aureus submitted synthesis synthesised therapeutic activity TMPRSS2 TMPRSS2 enzyme transmembrane serine protease Treatment Vanillin was tested [DOI] 10.1016/j.molstruc.2022.133659 [Article Type] Research article
Evidence of co-infections during Delta and Omicron SARS-CoV-2 variants co-circulation through prospective screening and sequencingArticle Published on 2022-11-012022-11-15 Journal: Clinical microbiology and infection : the official [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Analysis chimeric circulation Co-infection collected COVID-19 Delta Delta and Omicron VOC Epidemic epidemiologically evidence of France generate Genetic Health Infection K417N L452R Mutation nasopharyngeal sample omicron Pandemics pathogenic patients PCR assay polymorphism primer sets profile Recombination recombination event Respiratory samples S-gene mutation Sample SARS-CoV-2 SARS-CoV-2 co-infection SARS-CoV-2 genome SARS-CoV-2 variant screened sequence Sequencing single nucleotide Single nucleotide polymorphism Single nucleotide polymorphism screening SNP SNPs submitted Surveillance variant virus VoC was performed WGS whole genome Whole genome sequencing [DOI] 10.1016/j.cmi.2022.06.030 PMC 바로가기
The Clinical and Genomic Epidemiology of Rhinovirus in Homeless Shelters-King County, WashingtonArticle Published on 2022-10-072022-11-15 Journal: The Journal of Infectious Diseases [Category] 유전자 메커니즘, 치료기술, [키워드] acute respiratory illness analyzed circulating clinical Community congregate setting coronavirus disease COVID-19 COVID-19 pandemic cross-sectional Enrollment Epidemiology genomic Genomic analysis highest homeless shelter Infection King measure multiplex nasal swabs pandemic participant people experiencing homelessness Prevalence prevalent questionnaire Respiratory illness respiratory pathogen respiratory viral respiratory viral infection respiratory viruses rhinovirus RT-PCR Sample sequenced sequenced samples serotype serotypes study period submitted subset Surveillance Symptoms tested Trial virus Washington [DOI] 10.1093/infdis/jiac239 PMC 바로가기
Predicting COVID-19 disease severity from SARS-CoV-2 spike protein sequence by mixed effects machine learningResearch article Published on 2022-10-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] age and sex attribute bioinformatics chronic disease Comorbidity complex country COVID-19 COVID-19 disease severity data extraction Delta demonstrated Effect effort fixed GISAID heterogeneous include information Interpretation lack logistic regression models machine learning Meta-analysis Metadata Mild Mutation obesity omicron outcome pandemic Patient Predictive random random effect reduction in Repository risk robust SARS-CoV-2 SARS-CoV-2 sequence SARS-CoV-2 spike protein sequence severe disease severity Spike protein submitted subset time-consuming training vaccination variant viral genome sequence viral genomics virus while [DOI] 10.1016/j.compbiomed.2022.105969 [Article Type] Research article
A review of clinical efficacy data supporting emergency use authorization for COVID-19 therapeutics and lessons for future pandemicsArticle Published on 2022-10-012022-11-15 Journal: Clinical and translational science [Category] COVID19(2023년), SARS, 치료제, [키워드] Anti-inflammatory Antiviral approved authorization chloroquine/hydroxychloroquine Clinical data Clinical efficacy clinical evidence clinical study clinical trial coronavirus disease COVID-19 COVID-19 pandemic COVID-19 therapeutics Critical demonstrated drug Efficacy Emergency Emergency use authorization EUA Evidence FDA food Guidance majority medication Pandemics public health emergency question Randomized controlled trial RCT Regulatory Resilience statistically significant submitted subsequent Support supported therapeutic withdrawn [DOI] 10.1111/cts.13384 PMC 바로가기
Activity of ertapenem/zidebactam (WCK 6777) against problem EnterobacteralesArticle Published on 2022-09-302022-11-16 Journal: Journal of Antimicrobial Chemotherapy [Category] SARS, 비임상, [키워드] 1:1 active against activity administration breakpoint Dilution E. coli Escherichia coli evaluated experiments group healthcare increasingly indicated Infection inhibited isolate Klebsiella KPC Laboratory material MDR National nosocomial Outpatient over Parenteral pathogen Patient proportion regimen SARS-CoV-2 secondary submitted Support susceptibility Trial will drive [DOI] 10.1093/jac/dkac280 PMC 바로가기