Substance P – a regulatory peptide with defense and repair functions. Results and perspectives for the fight against COVID-19Neurology Perspective Published on 2024-05-302024-09-05 Journal: Frontiers in Neurology [Category] update2024, [키워드] blood–brain-barrier COVID-19 dysregulation immune response Endothelial dysfunction substance P vasoactive peptides [DOI] 10.3389/fneur.2024.1370454 PMC 바로가기 [Article Type] Neurology Perspective
Substance P and Prokineticin-2 are overexpressed in olfactory neurons and play differential roles in persons with persistent post-COVID-19 olfactory dysfunctionSubstance P와 Prokineticin-2는 후각 신경세포에서 과발현되며, 지속적인 COVID-19 후각 기능 장애가 있는 사람들에서 서로 다른 역할을 합니다.Article Published on 2023-02-012023-07-11 Journal: Brain, behavior, and immunity [Category] COVID19(2023년), [키워드] Anosmia COVID-19 Hyposmia Long COVID olfactory dysfunction olfactory neurons Prokineticin-2 substance P [DOI] 10.1016/j.bbi.2022.12.017 PMC 바로가기
[Effect mechanism of pricking and cupping therapy combined with Chinese herbal wet compress in treatment of herpes zoster based on Th1/Th2 imbalance and serum substance P][Th1/Th2 불균형 및 혈청 물질 P를 기반으로 한 대상포진 치료에서 침과 부항 요법과 중국 약초 습식 압박 요법의 효과 기전]Randomized Controlled Trial Published on 2022-09-252023-06-01 Journal: Zhen ci yan jiu = Acupuncture research [Category] 대상포진, 두창, 수두, 홍역, [키워드] Chinese herbal wet compress Cupping herpes zoster interferon gamma Interleukin 4 Pricking therapy substance P [DOI] 10.13702/j.1000-0607.20210893 [Article Type] Randomized Controlled Trial
Vasoactive Peptides: Role in COVID-19 Pathogenesis and Potential Use as Biomarkers and Therapeutic Targets혈관 활성 펩티드: COVID-19 발병의 역할 및 바이오마커 및 치료 표적으로서의 잠재적 사용Review Published on 2021-11-012022-09-11 Journal: Archives of medical research [Category] MERS, SARS, 바이오마커, 신약개발, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Ang II angiotensin Angiotensin II Biomarker Biomarkers bradykinin calcitonin calcitonin gene-related peptide cause coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 patient develop Effect Endothelin Endothelin-1 ET-1 global health Health Healthcare system intestinal management observation outbreak pathological conditions Patient peptide peptides physiological Potential potential therapeutic target potential therapeutic targets prognostic indicator respiratory Respiratory complications role SARS-CoV-2 severe acute respiratory syndrome Coronavirus substance P target the disease therapeutic target therapeutic targets Vasoactive vasoactive intestinal peptide Vasoactive peptides. VIP [DOI] 10.1016/j.arcmed.2021.05.007 PMC 바로가기 [Article Type] Review
Neurokinin-1 Receptor as a potential drug target for COVID-19 treatmentCOVID-19 치료를 위한 잠재적인 약물 표적으로서의 뉴로키닌-1 수용체Review Published on 2021-11-012022-09-11 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] SARS, 신약개발, 치료법, 치료제, [키워드] alleviate antagonist aprepitant biomedical scientist boost Brainstem clinical Clinical studies conducted Coronavirus infection Coronavirus treatment COVID-19 COVID-19 infection Cytokine storm Dexamethasone directions disease drug drug target Economy etiology hour immune system Infection Infectious disease Inflammation Neurokinin-1 Receptor antagonist neuromodulator neurotransmitter nociception novel Novel coronavirus Novel coronavirus infection pandemic Perspective receptor antagonist released respiratory Respiratory illness responsible substance substance P Substance P/ Neurokinin-1 Receptor antagonist. Symptom the disease therapeutic intervention Treatment Treatment strategies treatment strategy trigeminal nerve [DOI] 10.1016/j.biopha.2021.112159 PMC 바로가기 [Article Type] Review
Between two storms, vasoactive peptides or bradykinin underlie severity of COVID‐19?두 폭풍 사이에 혈관 활성 펩타이드 또는 브래디키닌이 COVID-19의 심각성을 뒷받침합니까?Review Published on 2021-03-092022-08-31 Journal: Physiological Reports [Category] 바이오마커, 진단, [키워드] accumulation ACE acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition bradykinin capture cause caused complications contribute coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 cytokine Cytokines develop disease disease severity dysregulated Evidence explain focus Inflammation mechanism microvascular permeability modulation molecular molecular mechanism neprilysin neurolysin neurotensin pandemic pathology Patient peptide peptidergic peptides primary mechanism progression provided respiratory responsible SARS‐CoV‐2 severe acute respiratory syndrome Coronavirus severity Signaling substance P the disease Treatment underlie vascular permeability Vasoactive [DOI] 10.14814/phy2.14796 PMC 바로가기 [Article Type] Review
Elevated serum substance P during simian varicella virus infection in rhesus macaques: implications for chronic inflammation and adverse cerebrovascular eventsArticle Published on 2020-12-012023-06-01 Journal: Journal of Neurovirology [Category] 두창, 수두, 홍역, [키워드] Simian varicella virus stroke substance P varicella Zoster [DOI] 10.1007/s13365-020-00907-3 PMC 바로가기
The Rationale for Angiotensin Receptor Neprilysin Inhibitors in a Multi-Targeted Therapeutic Approach to COVID-19Review Published on 2020-11-152022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, [키워드] “cytokine storm” ACE2 Acute heart failure acute respiratory distress acute respiratory syndrome adrenomedullin angiotensin Angiotensin II antagonist Apelin AT1R bradykinin clinical coronavirus COVID-19 COVID-19 patients cytokine Deceased decrease Degradation demonstrated determine disease down-regulation Efficacy elevated enzyme event expression fibroblast Healthcare system implicated Inflammation inhibitor Injury lung natriuretic peptide neprilysin organ injury peptides positive potential benefit randomized clinical trial rationale receptor reducing Remdesivir required sacubitril/valsartan SARS-CoV-2 SARS-COV-2 infection selective substance P syndrome systemic inflammation therapeutic strategy therapy for COVID-19 Thrombotic complications Tocilizumab Treatment Trial [DOI] 10.3390/ijms21228612 PMC 바로가기 [Article Type] Review
COVID-19 Usurps Host Regulatory NetworksPharmacology Published on 2020-08-142022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] ACE2 Activation acute respiratory syndrome Angiotensin II angiotensin-converting enzyme 2 Anti-viral therapy benefit bind bradykinin cause Cell Central nervous system characteristic Coagulation coagulation cascade complement complex Coronary heart disease coronavirus coronavirus disease COVID-19 deficiencies diabetes Effect effective hypertension identify immune Infection inflammatory signal inhibitor Intervention Kallikrein-kinin system Kidney disease lack manifestation medications network organ pathophysiological pathway Pathways Patient pharmacotherapy physiological pro-inflammatory condition prothrombotic RAAS renin-angiotensin-aldosterone system SARS-CoV-2 SARS-COV-2 infection substance P susceptible Symptom tissue damage Treatment underlying disease understanding while [DOI] 10.3389/fphar.2020.01278 PMC 바로가기 [Article Type] Pharmacology
Role of the Neurokinin-1 Receptor in the Promotion of Corneal Epithelial Wound Healing by the Peptides FGLM-NH 2 and SSSR in Neurotrophic KeratopathyCornea Published on 2020-07-222024-09-04 Journal: Investigative ophthalmology & visual science [Category] 대상포진, [키워드] AKT Corneal epithelium insulin-like growth factor 1 neurokinin-1 receptor Neurotrophic keratopathy persistent epithelial defect substance P [DOI] 10.1167/iovs.61.8.29 PMC 바로가기 [Article Type] Cornea