Aspergillus fumigatus secretes a protease(s) that displays in silico binding affinity towards the SARS-CoV-2 spike protein and mediates SARS-CoV-2 pseudovirion entry into HEK-293T cellsResearch Published on 2024-03-062024-09-05 Journal: Virology Journal [Category] update2024, [키워드] A. Fumigatus alkaline protease 1 Aspergillus (A) fumigatus HADDOCK HEK-293T cells SARS-CoV-2 spike protein supernatant transduction [DOI] 10.1186/s12985-024-02331-z PMC 바로가기 [Article Type] Research
Quantification of SARS-CoV-2 RNA in wastewater treatment plants mirrors the pandemic trend in Hong KongArticle Published on 2022-10-202022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, [키워드] applicability average Characteristics collected Community Concentration conducted contributing to correlation ENhance Epidemiology evaluated fecal Frequency Hong Kong key factor longitudinal Longitudinal monitoring MONITOR pandemic pathogen plant primer sets provide public health RNA SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 RNA SARS-CoV-2 virus supernatant Surveillance the SARS-CoV-2 virus Treatment ultracentrifugation virus was normalized wastewater WBE WWTP. [DOI] 10.1016/j.scitotenv.2022.157121 PMC 바로가기
In vitro inhibition of SARS-CoV-2 Infection by dry algae powdersArticle Published on 2022-10-122022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] antiviral activity antiviral property Arthrospira candidate Chlorella COVID-19 CPE Culture DMEM DMSO experiment fucoidan highest in viral in vitro incubated Infection inhibited investigated Post-infection purified reduced Safe Sargassum SARS-CoV-2 SARS-COV-2 infection significantly solvent supernatant TCID therapeutic Treatment Vero Cell viral inoculum Viral RNA was increased was used [DOI] 10.1038/s41598-022-22148-6 PMC 바로가기
Comparison of viral propagation and drug response among SARS-CoV-2 VOCs using replicons capable of recapitulating virion assembly and releaseArticle Published on 2022-10-012022-11-15 Journal: Virologica Sinica [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] acute respiratory syndrome assays Beta changed coronavirus Delta delta VoCs drug resistance drug response ENhance Evolution of SARS-CoV-2 genomes immune evasion inhibitor manifested Mutation novel antiviral drugs Protein provide quantification released remained Remdesivir replicon RNA S gene SARS-CoV-2 sgRNA supernatant Support Transcription variants variants of concern variants of concern (VOC) viral genome replication viral infectivity viral life cycle viral propagation Viral protein Viral-like particle (VLP). viral-like particles virion assembly VLP VoC VOCs WIV04 strain [DOI] 10.1016/j.virs.2022.06.008 PMC 바로가기
Vitamin D Supplementation Does Not Influence SARS-CoV-2 Vaccine Efficacy or Immunogenicity: Sub-Studies Nested within the CORONAVIT Randomised Controlled TrialArticle Published on 2022-09-162022-11-15 Journal: Nutrients [Category] SARS, 진단, [키워드] 25-hydroxyvitamin D 95% CI Acute respiratory infection adjusted hazard ratio antibody baseline blood sample BNT162b2 BNT162b2 Pfizer boost Breakthrough SARS-CoV-2 infection cellular response ChAdOx1 nCoV-19 ChAdOx1 nCoV-19 Oxford–AstraZeneca circulating collected Concentration concentrations Controlled deficiency determine dose dried blood spot Effect Efficacy elevated Follow-up IFN-γ IgA IgG IgM influence interferon interferon gamma investigated mean difference neutralising antibody neutralising antibody titre of BNT162b2 offer participant Pfizer Protective randomised controlled randomised controlled trial reported response risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination SARS-CoV-2 vaccine significantly supernatant titre titres vaccination venous Vitamin Vitamin D Vitamin D status vitamin D supplement Vitamin D supplementation Whole blood [DOI] 10.3390/nu14183821 PMC 바로가기
Rapid Cytokine Release Assays for Analysis of Severe Acute Respiratory Syndrome Coronavirus 2-Specific T Cells in Whole Blood전혈에서 중증 급성 호흡기 증후군 코로나바이러스 2-특이적 T 세포 분석을 위한 신속한 사이토카인 방출 분석Article Published on 2022-08-242022-09-11 Journal: The Journal of Infectious Diseases [Category] SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analyzed anti-receptor-binding domain antibody Blood samples characteristic clinical complicate Complication controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine cytokine Cytokine release assay diagnosed Diagnosis Diagnostic accuracy Donor EudraCT evaluated exhibited high accuracy IgG IgG levels Immunoglobulin Immunoglobulin G induction Infection interferon interferon γ memory memory response nucleocapsid Patient peptide peptides plasma Previous studies protocol Rapid receiver receiver operating characteristic Region Release remained respiratory SARS-CoV-2 seropositive serum severe acute respiratory syndrome Coronavirus spike stimulated study participant supernatant T cells T-cell T-cell immunity Trial vaccine doses waned Whole blood [DOI] 10.1093/infdis/jiac005 PMC 바로가기 [Article Type] Article
Detection of SARS-CoV-2 RNA throughout wastewater treatment plants and a modeling approach to understand COVID-19 infection dynamics in Winnipeg, Canada폐수 처리장 전체에서 SARS-CoV-2 RNA 검출 및 캐나다 위니펙의 COVID-19 감염 역학을 이해하기 위한 모델링 접근 방식Article Published on 2022-06-152022-09-11 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, 치료법, [키워드] applied approach Back-trajectory modeling Canada Concentration Consensus correlation correlations COVID-19 infection Data analysis detection discharge Final fluctuation fluctuations fraction indicated infected individual Infection initial plant plants positive control processing reached reduction RNA RNA concentrations sample collection SARS-CoV-2 SARS-CoV-2 RNA sensitivity Sludge suggested supernatant Surveillance Treatment virus virus concentration wastewater Wastewater solids wastewater surveillance water water cycle Winnipeg [DOI] 10.1016/j.scitotenv.2022.153906 PMC 바로가기 [Article Type] Article
Protocol to isolate and assess spike protein cleavage in SARS-CoV-2 variants obtained from clinical COVID-19 samplesArticle Published on 2022-06-132022-10-05 Journal: STAR protocols [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] cell entry cellular proteases cleavage cleaved Complete COVID-19 sample ENhance Evolutionary biology facilitate in viral include Isolation Microbiology Nasopharyngeal swab patients with COVID-19 protocol SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2-infected cells spike mutation Spike protein supernatant [DOI] 10.1016/j.xpro.2022.101502 [Article Type] Article
Evidence of Infection of Human Embryonic Stem Cells by SARS-CoV-2SARS-CoV-2에 의한 인간 배아 줄기 세포 감염의 증거Article Published on 2022-06-102022-09-11 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 cell types coronavirus described differentially expressed dsRNA embryonic embryos enterocytes Evidence evidence of Gut hepatocytes hESC Human immunofluorescence microscopy infect Infection interferon-stimulated gene interferon-stimulated genes ISGs life cycle low expression mechanism neurons question replicate Replication replication of SARS-CoV-2 reported Respiratory system RNA S protein SARS-CoV-2 SARS-CoV-2 receptors severe acute respiratory syndrome Coronavirus significantly STEM stem cell supernatant supernatants Support syncytium threshold upregulated variety Viral RNA viral titer viral titers virion virus were infected [DOI] 10.3389/fcimb.2022.911313 PMC 바로가기 [Article Type] Article
Soluble P2X7 Receptor Is Elevated in the Plasma of COVID-19 Patients and Correlates With Disease Severity가용성 P2X7 수용체는 COVID-19 환자의 혈장에서 상승하고 질병 중증도와 상관관계가 있습니다Article Published on 2022-05-182022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] activated Activation acute respiratory distress Bacterial Biomarker C-reactive protein concentration cause cell death characterized Concentration COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients COVID-19 severity cytokine danger signal death experimental evidence extracellular ATP hypoxia IL-1 receptor antagonist IL-18 IL-1β IL-6 increase in induce inflammasome activation Inflammation Inflammatory response lung mononuclear cell NLRP3 NLRP3 inflammasome P2X7 Peripheral blood pharmacological target plasma Pneumonia positively correlated pro-inflammatory cytokines purinergic receptors pyroptosis receptor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected individual supernatant syndrome triggered triggering viral infections with COVID-19 [DOI] 10.3389/fimmu.2022.894470 PMC 바로가기 [Article Type] Article