suppresse – Communicable Diseases Research

Punicalagin as an allosteric NSP13 helicase inhibitor potently suppresses SARS-CoV-2 replication in vitro

Article

Published on 2022-10-012022-11-15
Journal: Antiviral Research [Category] COVID19(2023년), SARS, 치료제,

Peimine inhibits variants of SARS-CoV-2 cell entry via blocking the interaction between viral spike protein and ACE2

Article

Published on 2022-10-012022-11-16
Journal: Journal of food biochemistry [Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 acute respiratory syndrome addition Analysis binding affinity block Calu-3 caused cell entry complementary coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients docking drug energy transfer evade exhibit Fritillaria functional glycoprotein Hydrogen bond Infection inhibit inhibit SARS-CoV-2 inhibitor Interaction lung cells molecular docking analysis N501Y patients peimine. Protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 viral infection significantly small molecule suggested suppresse the spike protein treatment for COVID-19 Vaccine variant variant spike variants of concern variants of SARS-CoV-2 viral entry viral infection viral infections viral spike viral spike protein VoC VOCs
[DOI] 10.1111/jfbc.14354 PMC 바로가기

Highlights of clinical and laboratory parameters among severe COVID-19 patients treated with tocilizumab: a retrospective observational study

Article

Published on 2022-09-012022-11-15
Journal: São Paulo medical journal = Revista paulista de medicina [Category] 진단, 치료기술,

[키워드] Admission age Analysis analyzed C-reactive protein (CRP Chest Clinical characteristics Comparative conducted Coronavirus disease 2019 COVID-19 COVID-19 patient CRP CRP level CRS Cytokine release syndrome database died disease evaluate ferritin high mortality hospital Hospitalized IL-6 independent risk factor information interleukin-6 laboratory parameter Logistic regression analysis lymphocyte Mortality neutrophil no difference oxygen saturation Patient performed receiving Research retrospective severe COVID-19 patient Signal transduction significantly lower suppresse survival group survived the patient Tocilizumab tocilizumab administration treated Treatment Turkey WBC White blood cell
[DOI] 10.1590/1516-3180.2021.0604.R1.23112021 PMC 바로가기

Attenuation of SARS-CoV-2 replication and associated inflammation by concomitant targeting of viral and host cap 2′-O-ribose methyltransferases

Article

Published on 2022-09-012022-11-15
Journal: The EMBO Journal [Category] COVID19(2023년), SARS, 치료제,

Plasma metabolome and cytokine profile reveal glycylproline modulating antibody fading in convalescent COVID-19 patients

혈장 대사체 및 사이토카인 프로필은 회복기 COVID-19 환자에서 글리실프롤린 조절 항체 퇴색을 나타냅니다

Article

Published on 2022-08-232022-09-11
Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 바이오마커, 진단,

[키워드] accumulated Accuracy acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alteration antibody association catalyzed cleavage conducted convalescent convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient Convalescent patients coronavirus COVID-19 COVID-19 convalescent patients COVID-19 pandemic cytokine cytokine profile cytokine profiling Cytokines demonstrated dipeptide dipeptidyl peptidase Dipeptidyl peptidase 4 domain down-regulate DPP4 experiment feature Feature selection glycylproline healthy healthy subjects IL-12p40 immune response immune responses individual inhibitor inhibitory effect Inhibitory effects M-CSF machine-learning mechanism metabolite metabolites metabolome metabolomics mice modulating neutralizing antibody outcome peptide plasma Plasma cytokine product public health Quantitative respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccination severe acute respiratory syndrome Coronavirus sitagliptin suppresse therapeutic Treatment vaccination Vaccination strategy with COVID-19
[DOI] 10.1073/pnas.2117089119 PMC 바로가기 [Article Type] Article

An intranasal ASO therapeutic targeting SARS-CoV-2

SARS-CoV-2를 표적으로 하는 비강내 ASO 치료제

Article

Published on 2022-08-032022-09-11
Journal: Nature Communications [Category] SARS, 변종, 진단, 치료기술, 치료법, 치료제,

[키워드] administration antibody immunity Antisense oligonucleotide ASO binding complement conserved coronavirus COVID-19 COVID-19 pandemic Daily decrease disrupt Efficacy effort evade help higher infectivity human cells identify in vitro in vivo infected individuals Inhaled intranasal leader sequence lung Lungs mice new SARS-CoV-2 Non-invasive nucleic acid Pandemics Prevent preventing infection Rapid reduce RNA SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 variant sequence severity of COVID-19 suppresse tested the SARS-CoV-2 therapeutic Therapeutic approach therapeutic strategy therapeutic targeting tide Transmission turn vaccination Vaccine variant Viral viral replication Viral RNA
[DOI] 10.1038/s41467-022-32216-0 PMC 바로가기 [Article Type] Article

Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2

바이러스 E 단백질은 SARS-CoV-2의 BET 단백질 매개 진입 후 길항작용을 중화합니다

Article

Published on 2022-07-192022-09-11
Journal: Cell Reports [Category] COVID19(2023년), SARS, 치료제,

[키워드] ACE2 ACE2 expression acetylated acute respiratory syndrome acute respiratory syndrome coronavirus angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Antiviral antiviral response BET BET inhibitors BET proteins bind BRD2 BRD3 BRD4 bromodomain Cell coronavirus COVID-19 CP: Microbiology Critical Depletion domain downregulate E protein enzyme exacerbate Factor histone histone mimetic inactivated inactivation Infection inhibitor inhibitors interferon interferon response mice Microbiology Mortality neutralization neutralize overexpressing Protein Replication SARS-CoV-2 SARS-COV-2 infection Support suppresse treated Treatment viral replication
[DOI] 10.1016/j.celrep.2022.111088 PMC 바로가기 [Article Type] Article

Recent Progress in the Development of Opaganib for the Treatment of Covid-19

Covid-19 치료를 위한 Opaganib 개발의 최근 진행 상황

Review

Published on 2022-07-122022-09-11
Journal: Drug design, development and therapy [Category] COVID19(2023년), SARS, 치료제,

[키워드] ABC294640 acceleration active against Administered Anti-SARS-CoV-2 Activity Antiviral antiviral activity biochemical Cancer clearance clinical trial COVID-19 pandemic decrease demonstrated development dihydroceramide desaturase disease driven by drug enzyme glucosylceramide glucosylceramide synthase Host Infection Inflammation Inflammatory diseases inhibit inhibiting mechanism metabolism Mild Mild disease moderate moderately severe COVID-19 modulation Mortality multi-organ dysfunction opaganib pandemic pathologic pathologic processes Patient patients patients hospitalized phase Progress recent regulate Replication replication of SARS-CoV-2 SARS-CoV-2 SARS-CoV-2 virus Signaling sphingolipid sphingolipids sphingosine sphingosine kinase. Stress subpopulation suppresse the SARS-CoV-2 virus treat Treatment treatment protocols understanding viral proliferation virus
[DOI] 10.2147/DDDT.S367612 PMC 바로가기 [Article Type] Review

Monocytic-Myeloid Derived Suppressor Cells Suppress T-Cell Responses in Recovered SARS CoV2-Infected Individuals

단핵구 골수 유래 억제 세포는 회복된 SARS CoV2에 감염된 개인의 T 세포 반응을 억제합니다

Article

Published on 2022-06-242022-09-11
Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, 치료법, 치료제,

[키워드] adaptive immune responses Antigen arginase caused CD11b CD14 CD33 CD57 Cell characterized clinical recovery coronavirus disease Coronavirus disease 2019 correlated COVID-19 CX3CR1 CXCL1 CXCL2 cytokine production Cytokine storm Cytokines depleting dominant downregulated DQA1 DQB1 effector memory expansion Frequency function functional functions Gene Expression HLA-B HLA-DQA1 HLA-DQB1 HLA-DR Hyperinflammatory Hyperinflammatory response IL-6 IL1β immune immune activation immune responses individual individuals infected individual Infection membrane monocytic-myeloid derived suppressor cells mononuclear cell NLRP3 nucleocapsid pathway Pathway analysis Pathways PBMC PD1 peptide peptide pool peptide pools Peripheral blood Peripheral blood mononuclear cells plasma quantity recall recovered regulate remained response RNA-Seq ROS SARS Coronavirus SARS coronavirus 2 SARS CoV2 infection shown spike glycoprotein subset suppress suppresse suppressed suppressor T cell T cell response T cell responses T-cell T-cell responses target TGFβ transcriptional transcriptomic transcriptomic (RNA-Seq). Vaccine viral infection virus
[DOI] 10.3389/fimmu.2022.894543 PMC 바로가기 [Article Type] Article

Nucleopore Traffic Is Hindered by SARS-CoV-2 ORF6 Protein to Efficiently Suppress IFN-β and IL-6 Secretion

IFN-β 및 IL-6 분비를 효율적으로 억제하기 위해 SARS-CoV-2 ORF6 단백질에 의해 핵공 이동이 방해됨

Article

Published on 2022-06-112022-09-11
Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] Activation addition antagonistic antiviral response block cascade characterized clinical outcomes contributing to counteract Critical cytokine Cytokines cytoplasm cytoplasmic demonstrated ENCODE exacerbated Factors feature Genes Host host immune system IFN-β IL-6 immune immune evasion Infection Inflammation interferon interferon antagonist interleukin interleukin-6 MAVS MDA-5 mechanism Messenger RNA movement mRNA multifunctional NF-κB not affected novel SARS-CoV-2 virus nuclear translocation nucleus occurred ORF6 pro-inflammatory cytokine pro-inflammatory cytokines Protein reported RIG-I SARS-CoV-2 SARS-CoV-2 ORF6 protein SARS-CoV-2 virus Signaling STAT suppresse suppression the SARS-CoV-2 Traffic transcription factor transcription factors transcriptional viral infection viral pathogenesis virulence virus
[DOI] 10.3390/v14061273 PMC 바로가기 [Article Type] Article