From the Wuhan-Hu-1 strain to the XD and XE variants: is targeting the SARS-CoV-2 spike protein still a pharmaceutically relevant option against COVID-19?우한-Hu-1 변종에서 XD 및 XE 변종까지: SARS-CoV-2 스파이크 단백질을 표적으로 하는 것이 여전히 COVID-19에 대한 약학적으로 적절한 옵션입니까?Article Published on 2022-12-012022-09-11 Journal: Journal of Enzyme Inhibition and Medicinal Chemist [Category] COVID19(2023년), SARS, 변종, [키워드] contributing to COVID-19 COVID-19 pandemic death Efficacy feature glycoprotein hospitalisations infections milestone MPro Mutation mutations outbreak pandemic Paxlovid Protein reported SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant spike Spike protein Surface glycoprotein the SARS-CoV-2 the SARS-CoV-2 genome the Spike Treatment Vaccines variant viral surface Wuhan-Hu-1 XD variant XE variant. [DOI] 10.1080/14756366.2022.2081847 PMC 바로가기 [Article Type] Article
Temporal dynamics of SARS-CoV-2 genome and detection of variants of concern in wastewater influent from two metropolitan areas in ArkansasArticle Published on 2022-11-252022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Affect approach Arkansas association Asymptomatic changes in Community complementary contribute coronavirus COVID-19 COVID-19 case COVID-19 testing death detect diagnostic Factors fecal genetic diversity Genetic variant genomic change highlight identity infected individual investigated nucleocapsid ORF1ab polymerase chain polyprotein public health quantified Quantitative recorded RNA sequencing RT-qPCR RT-qPCR assay SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 mutations SARS-CoV-2 RNA SARS-CoV-2 variant sensitivity silent Support Surface glycoprotein Surveillance TaqMan assay target Temporal the disease transmission of SARS-CoV-2 variants variants of concern viral gene viral titer virus virus genome was used wastewater [DOI] 10.1016/j.scitotenv.2022.157546 PMC 바로가기
The mutation features and geographical distributions of the surface glycoprotein (S gene) in SARS-CoV-2 strains: A comparative analysis of the early and current strainsArticle Published on 2022-11-012022-11-16 Journal: Journal of medical virology [Category] SARS, 변종, [키워드] ACE2-binding region acute respiratory syndrome Analysis analyzed coronavirus coronavirus disease COVID-19 COVID-19 vaccines demonstrated develop Evolution feature Frequency Genome genome mutations geographical distribution highest identify loci mutant strain Mutation omicron prevalent remained Result S gene S protein SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 variant strain Strains Surface glycoprotein the receptor-binding domain the S protein The United States United Kingdom Vaccines was used [DOI] 10.1002/jmv.28023 PMC 바로가기
Antibody and T-cell responses by ultra-deep T-cell receptor immunosequencing after COVID-19 vaccination in patients with plasma cell dyscrasiasArticle Published on 2022-11-012022-11-15 Journal: British Journal of Haematology [Category] 진단, [키워드] age anti-CD38 antibodies antibody Antibody Response Antibody testing antibody titres Antigen binding domain BNT162b2 breadth Cell comparable coronavirus disease correlated COVID-19 COVID-19 vaccination demonstrated detectable dose dyscrasia elicit Genome healthy humoral immune immunization Immunocompromised Immunoglobulin Increasing initial Intervention investigated JNJ-78436735 maturation median mRNA vaccine mRNA-1273 Myeloma of BNT162b2 Patient patient population plasma Population proportion receiving Region response spike-specific T-cell Spike-specific T-cell responses Surface glycoprotein T-cell T-cell receptor T-cell Response TCR tested therapy underlying disease vaccination Vaccines [DOI] 10.1111/bjh.18434 PMC 바로가기
The effect of Omicron breakthrough infection and extended BNT162b2 booster dosing on neutralization breadth against SARS-CoV-2 variants of concernArticle Published on 2022-10-032022-11-15 Journal: PLoS Pathogens [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] BNT162b2 booster breadth Breakthrough infection Coverage COVID-19 COVID-19 pandemic COVID-19 vaccine ENhance extended interval generate identify immune response immune responses immunogen individual Lineage magnitude memory B cells Mutation neutralization activity neutralization breadth Neutralizing antibody response of BNT162b2 omicron Population proportion reactive receiving regimen SARS-CoV-2 variant second dose spike Surface glycoprotein two groups vaccination Vaccination strategy Vaccine vaccine dose [DOI] 10.1371/journal.ppat.1010882 PMC 바로가기
(+)-Usnic Acid and Its Derivatives as Inhibitors of a Wide Spectrum of SARS-CoV-2 VirusesArticle Published on 2022-09-292022-11-15 Journal: Viruses [Category] SARS, 치료제, [키워드] acid Antiviral antiviral action antiviral activity Antiviral compound binding site Compound compounds Delta derivative exhibit glycoprotein hemoglobin inhibitory activity main viral protease 3CLPro mechanism metabolite molecular Molecular modeling N-terminal domain omicron performed protease SARS-CoV-2 SARS-CoV-2 virus shown Spectrum strain Strains Surface glycoprotein surface glycoprotein S usnic acid virus virus SARS-CoV-2. Wuhan [DOI] 10.3390/v14102154 PMC 바로가기
Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza virusesArticle Published on 2022-09-022022-10-06 Journal: Nature Communications [Category] Fulltext, 신종인플루엔자, 진단, [키워드] analyses antibody antiviral drug benefit chimeric conserved cross-neutralization cross-neutralizing cross-protection eight engage epitope overlapping Evidence H1N1 H5N1 identification in vivo Influenza influenza vaccines Influenza virus mAb molecular monoclonal antibody neutralization Neutralizing activity offer pandemic receptor binding site residue Surface glycoprotein target Tolerance Vaccine viral challenge virus virus entry viruses [DOI] 10.1038/s41467-022-32926-5 PMC 바로가기 [Article Type] Article
Mucosal administration of a live attenuated recombinant COVID-19 vaccine protects nonhuman primates from SARS-CoV-2 Research Published on 2022-07-292022-10-05 Journal: NPJ Vaccines [Category] 비임상, 임상, 치료기술, 치료법, [키워드] acute respiratory syndrome administration African green monkey AGM AGMs Beta chimeric clinical trial coronavirus COVID-19 COVID-19 vaccine cross-neutralization Delta elicited exhibited expressing global pandemic host cells immunogenic immunoglobulin A intranasal Live attenuated vaccine mucosal neutralizing antibody Phase 1 PROTECT recombinant COVID-19 vaccine reducing respiratory syncytial virus RNA virus SARS-CoV-2 SARS-CoV-2 spike serum Surface glycoprotein trimeric viral envelope protein virus variant [DOI] 10.1038/s41541-022-00509-6 [Article Type] Research
Computational study and design of effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains인도 SARS-CoV-2 균주의 구조 단백질 관련 유전자를 침묵시키는 효과적인 siRNA의 계산 연구 및 설계Article Published on 2022-06-012022-09-11 Journal: Computational biology and chemistry [Category] COVID19(2023년), SARS, 치료법, 치료제, [키워드] absence acute respiratory disease Ago2 Algorithm animal models antiviral drug antiviral drugs Antiviral treatment binding candidate collected complementary Consensus COVID-19 deaths docking Effect effective envelope protein feature free energy GC content gene silencing Genes Genome Health Organization heat capacity Human Human genome in vitro in vivo India melting temperature membrane protein molecular docking analysis nucleic acid nucleocapsid nucleotide nucleotides outbreak pandemic parameter pathogenic coronavirus pathway Post-transcriptional gene silencing Protein public health Region reported Respiratory disease RNA RNA interference RNAi SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 strains selected sequence sequenced siRNA siRNA molecule siRNA molecules siRNAs structural protein structural proteins Surface glycoprotein target target gene target mRNA temperature Therapeutic treatment triggered viral pathogenesis WHO World Health Organization [DOI] 10.1016/j.compbiolchem.2022.107687 PMC 바로가기 [Article Type] Article
A conserved subunit vaccine designed against SARS-CoV-2 variants showed evidence in neutralizing the virusSARS-CoV-2 변이체에 대해 설계된 보존 소단위 백신은 바이러스를 중화하는 증거를 보여주었습니다Article Published on 2022-06-012022-09-11 Journal: Applied Microbiology and Biotechnology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] addition affinity analyzed antibody approach B-cell response conserved coronavirus coronavirus disease country Coverage COVID-19 Cytopathic effect docking domain Efficiency elicit envelope envelope protein epitope Epitope-based vaccine Epitopes Evidence FIVE genomes glycoprotein highest IgG immunogenic immunoinformatics IMPROVE induce linker lung tissue membrane membrane glycoprotein MHC MHC class MHC class I MHC class II mice molecular molecular docking Multi-epitope vaccine Mutation neutralize Neutralizing Neutralizing antibodies neutralizing antibody novel Novel coronavirus omicron outbreak pandemic peptide peptides Proteins recognize reported required S1 and S2 S2 domain SARS-CoV-2 SARS-CoV-2 genomes SARS-CoV-2 variant SARS-CoV-2 variants selected sequence sequences spike Spike surface glycoprotein, Immunogenic, Neutralizing antibody. Spread step subunit Subunit vaccine Surface glycoprotein surface protein surface proteins T-cell T-cell epitope T-cell epitopes the vaccine Vaccine vaccine construct variant variants variants of SARS-CoV-2 Vero Cell viral surface virus virus replication wild type wild-type virus [DOI] 10.1007/s00253-022-11988-x PMC 바로가기 [Article Type] Article