A critical review of diagnostic and prognostic markers of chronic hepatitis B infectionReview Published on 2024-05-082024-09-05 Journal: Medical review [Category] update2024, [키워드] chronic hepatitis prognostic scores sero-markers surrogate markers [DOI] 10.1515/mr-2024-0022 PMC 바로가기 [Article Type] Review
Research progress on detection methods for hepatitis B virus covalently closed circular DNAReview Published on 2023-05-012023-06-11 Journal: Journal of viral hepatitis [Category] B형 간염, [키워드] cccDNA detection HBV infection polymerase chain reaction surrogate markers [DOI] 10.1111/jvh.13817 [Article Type] Review
Clinical Characteristics of COVID-19: Use of Steroids in Mostly Unvaccinated COVID-19 Patients Before the Omicron VariantCOVID-19의 임상적 특징: Omicron 변이 이전에 대부분 백신을 접종하지 않은 COVID-19 환자에서 스테로이드 사용Article Published on 2022-07-252022-09-11 Journal: Journal of Korean medical science [Category] COVID19(2023년), SARS, 변종, [키워드] 95% CI 95% confidence interval adjusted odds ratio allergy Antibiotics Chain Reaction clinical Clinical data collected Comorbidities Comorbidity concomitant use coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patients demographic Demographic and clinical data described diagnosed with COVID-19 dose electronic medical records enrolled Factor Glucocorticoids groups help high risk hospital independent risk factor independent risk factors Infectious disease initial investigated Lactate lactate dehydrogenase LDH lower dose lymphopenia medication medications moderate moderate to severe Mortality Multivariate analysis omicron Ordinal Scale outlier outliers oxygen Oxygen therapy patients polymerase chain reaction proportion real-time reverse transcription-polymerase chain reaction RECOVERY trial Remdesivir Reverse transcription-polymerase chain reaction risk SARS-CoV-2 scale severe coronavirus disease severity steroid steroid use Steroids subject surrogate markers therapy treated Treatment use of steroids were measured [DOI] 10.3346/jkms.2022.37.e228 PMC 바로가기 [Article Type] Article
Evaluation of commercial Anti-SARS-CoV-2 neutralizing antibody assays in seropositive subjects혈청 양성 환자에서 상업용 Anti-SARS-CoV-2 중화 항체 분석 평가Article Published on 2022-07-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] absence added addition anti-RBD Anti-RBD antibodies Anti-RBD antibody anti-spike antibody anti-Spike IgG antibody Antibody titer Area bioMérieux cells cellular receptor Commercial tests Competitive anti-RBD immunoassays correlation difficulty functional highlight house immunoassay immunoassays immunochromatographic test Interaction marker NAb titer NAb titers neutralization test Neutralizing antibodies neutralizing antibody neutralizing antibody assay New P-value patients plaque reduction neutralization PRNT qualitative test Quantitative reduction SARS-CoV-2 SARS-CoV-2 entry Sensitivity and specificity sera seropositive subject seropositive subjects Spike protein surrogate surrogate markers Surrogate markers of protection. sVNT tested the spike protein threshold thresholds titer variants of concern virus neutralization test VNT VoC [DOI] 10.1016/j.jcv.2022.105169 PMC 바로가기 [Article Type] Article
Detectable Duration of Viable SARS-CoV-2, Total and Subgenomic SARS-CoV-2 RNA in Noncritically Ill COVID-19 Patients: a Prospective Cohort Study중증이 아닌 COVID-19 환자에서 생존 가능한 SARS-CoV-2, 전체 및 서브게놈 SARS-CoV-2 RNA의 감지 가능한 기간: 전향적 코호트 연구Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 바이오마커, 치료기술, [키워드] 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis clearance collected coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Culture Determination determine diagnosed Duration Evidence Factor feasibility gold gold standard hazard ratio Ill Immunocompromised Immunocompromised patients infection control Infectivity interquartile range investigated Isolation Kinetics marker median time N gene Nasopharyngeal swab nasopharyngeal swabs negativity Patient Prospective prospective cohort receipt Reinfection respiratory reverse transcription PCR RNA RNA RT-PCR RT-PCR SARS-CoV-2 SARS-CoV-2 RNA SARS-CoV-2 sgRNA SARS-CoV-2 sgRNAs severe acute respiratory syndrome Coronavirus sgRNA sgRNAs steroid subgenomic RNA subgenomic RNAs surrogate markers time Total total RNA transcript Viable Viral viral culture viral infectivity Viral RNA viral shedding [DOI] 10.1128/spectrum.00503-22 PMC 바로가기 [Article Type] Article
Loss of Detection of sgN Precedes Viral Abridged Replication in COVID-19-Affected Patients—A Target for SARS-CoV-2 PropagationCOVID-19에 감염된 환자에서 sgN 검출 손실이 바이러스 요약 복제보다 먼저 발생 - SARS-CoV-2 전파의 표적Article Published on 2022-02-092022-09-10 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), MERS, SARS, 변종, 치료기술, 치료법, 치료제, [키워드] 2′-O-methyl antisense RNA ACE2 addition Alpha Analysis B.1.1.7 correlation correlations Cq value Cq values detection Disease progression Early detection evaluated focus future therapeutic HEK-293T cell HEK-293T cells Hospitalized human cell human cells impair in vitro study indicated Infection Loss marker ORF1ab overexpressing Patient patient condition positive sample Propagation Prophylactic public health qPCR qPCR methods RNA RNA transcript RNase P SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2 virus SARS-CoV-2 virus particles sequence sgE sgN shown surrogate markers Swab syncytia formation target the SARS-CoV-2 virus variant Viral viral loads viral replication virus replication VoC [DOI] 10.3390/ijms23041941 PMC 바로가기 [Article Type] Article
Identifying possible surrogate markers of COVID19 as a supplement to diagnostic testing in Upstate New YorkUpstate New York에서 진단 테스트를 보완하기 위해 COVID 19의 가능한 대리 마커 식별Article Published on 2021-12-012022-09-11 Journal: The American journal of emergency medicine [Category] 바이오마커, [키워드] Acuity analyzed calculated chest imaging Cohort conducted conjunction correlation cough Course COVID COVID19 COVID19 clinical characteristics COVID19 diagnostic testing COVID19 hypercoagulability COVID19 inflammatory state COVID19 surrogate markers COVID19 symptomology COVID19 triage CRP diagnostic diagnostic testing discharge Diseases emergency department Emergency Departments ESR fatigue group healthcare hospital hypercoagulability identifying Infection Infectious diseases Inflammation Inflammatory Inpatient lactic acid marker nasopharyngeal New York non-specific Patient PCR test physical positive raised reference range required resource Retrospective study Sensitivity and specificity Shortness of breath significantly higher surrogate markers Symptom Symptoms tissue damage trauma Trauma Center Triage troponin while [DOI] 10.1016/j.ajem.2021.09.036 PMC 바로가기 [Article Type] Article
HeberNasvac, a Therapeutic Vaccine for Chronic Hepatitis B, Stimulates Local and Systemic Markers of Innate Immunity: Potential Use in SARS-CoV-2 Postexposure Prophylaxis만성 B형 간염에 대한 치료 백신인 HeberNasvac은 선천 면역의 국소 및 전신 표지자를 자극합니다: SARS-CoV-2 노출 후 예방에 잠재적 사용Article Published on 2021-07-012022-09-11 Journal: Euroasian J Hepatogastroenterol [Category] 비임상, [키워드] Acute respiratory infection acute respiratory infections acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral antiviral properties antiviral property both sexes breath CHB chronic chronic hepatitis Chronic Hepatitis B clinical trial Cohort coronavirus coronavirus disease COVID-19 Dengue died Disease progression dose enrolled evidenced expression functional Hepatocellular carcinoma immune cells Immunity immunomodulating immunomodulatory immunomodulatory effect impairment increased expression Innate innate immune cell Innate immune cells Innate immunity intranasal lethal infection Local Lymphocytes malignancies malignancy marker material mice monocyte Monocytes mononuclear cell nasopharyngeal Older Open-label pandemic Patient patients PBMC Peripheral blood periphery Postexposure Postexposure Prophylaxis Potential presenting prophylactic therapy Prophylaxis randomized clinical trial reduction in respiratory infections Result Safe SARS-CoV-2 severe acute respiratory syndrome Coronavirus shown subjects surrogate markers Symptom symptoms of COVID-19 systemic the patient therapeutic therapy Toll-like receptor Toll-like receptors tonsils Treatment Vaccine [DOI] 10.5005/jp-journals-10018-1344 PMC 바로가기 [Article Type] Article
Dead space estimates may not be independently associated with 28-day mortality in COVID-19 ARDS데드 스페이스 추정치는 COVID-19 ARDS의 28일 사망률과 독립적으로 연관되지 않을 수 있습니다.Observational Study Published on 2021-05-172022-09-11 Journal: Critical Care [Category] 바이오마커, 임상, [키워드] 28-day mortality acute respiratory distress acute respiratory distress syndrome added Analysis ARDS baseline case sery Comorbidity consecutive patient consecutive patients Course COVID-19 dead Dead space dead space ventilation determine direct method eligible end-tidal estimate estimation fraction ICU impairment increase in increased risk information intensive care unit invasive ventilation marker mechanical ventilation Mortality multicenter National Netherlands non-survivor observational study outbreak Participation Patient prognostic Prognostic value Prognostication quantification Registered Respiratory dead space respiratory distress Respiratory distress syndrome Result retrospective risk secondary severity shown significantly significantly higher supplementary material surrogate markers survivor syndrome the dead Trial registration Ventilation ventilatory Ventilatory ratio [DOI] 10.1186/s13054-021-03570-0 PMC 바로가기 [Article Type] Observational Study
Antibody Response against SARS-CoV-2 and Seasonal Coronaviruses in Nonhospitalized COVID-19 Patients입원하지 않은 COVID-19 환자의 SARS-CoV-2 및 계절성 코로나바이러스에 대한 항체 반응Research Article Published on 2021-02-242022-09-10 Journal: mSphere [Category] MERS, 진단, 치료기술, 치료법, 치료제, [키워드] 229E addition addressed ADE antibody Antibody Response antibody response against Antibody responses Antibody-dependent enhancement antibody-dependent enhancement (ADE) Asymptomatic breadth conducted contribute coronavirus coronavirus 229E correlated Course COVID-19 cross-protection detect develop diagnostic diagnostic test difficulty Dilution disease experiments highlight Hospitalization human cell human cells Immunity individual infected individuals Infection involved majority marker Mild neutralization Neutralizing activity Neutralizing antibodies Neutralizing antibody response neutralizing antibody responses nucleocapsid Patient phenomenon positive predictor quantified question receptor binding site response S protein SARS-CoV-2 SARS-CoV-2 neutralization seasonal seasonal coronaviruses sera serological Serological assay serological survey Serum Neutralization Spike protein surrogate markers symptomatic targets the S protein the spike protein to define Vaccine development Virus neutralization western blot [DOI] 10.1128/mSphere.01145-20 PMC 바로가기 [Article Type] Research Article