Molecular Analyses of Clinical Isolates and Recombinant SARS-CoV-2 Carrying B.1 and B.1.617.2 Spike Mutations Suggest a Potential Role of Non-Spike Mutations in Infection KineticsArticle Published on 2022-09-122022-11-15 Journal: Viruses [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome addition analysis B.1 B.1.617.2 BAC BAC mutagenesis backbone Bacterial bronchial epithelial cells Carrying chromosome clinical comparable coronavirus Cytopathic effect disease Efficiency en passant mutagenesis epithelial cell line evaluate generate glycoprotein human lung Infection infectious virus inhibitors isolate isolates Kinetics less Microscopy monoclonal antibody Mutagenesis Mutation neutralization nonstructural proteins nucleocapsid Numerous Post-vaccine Potential progression raise recombinant RNA role SARS-CoV-2 sera severity spike spike mutation spike mutations Spike protein spike protein. Substitution suggested susceptible Syncytia Transmissibility Treatment variant viral fitness viral spike virus Virus life cycle VoC [DOI] 10.3390/v14092017 PMC 바로가기
Acquisition of Furin Cleavage Site and Further SARS-CoV-2 Evolution Change the Mechanisms of Viral Entry, Infection Spread, and Cell Signaling푸린 절단 부위의 획득 및 추가 SARS-CoV-2 진화는 바이러스 진입, 감염 확산 및 세포 신호 전달의 메커니즘을 변경합니다Article Published on 2022-08-102022-09-11 Journal: Journal of Virology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 acquisition activate activating Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response alphavirus appear cathepsin Cathepsins Cell Cell fusion change coronavirus COVID COVID-19 disease Cytokines Deletion determined by endosome Entry mechanism entry pathway Evolution experimental system expressing S protein expression FCS furin furin cleavage furin cleavage site hallmark human population immune in vitro induce infected with SARS-CoV-2 infecting Infection inhibitor inhibitors lack leads Lineage mAbs mechanism media mRNA vaccines Neutralizing neutralizing monoclonal antibodies neutralizing monoclonal antibody pro-inflammatory cytokines pro-inflammatory response pseudoinfectious viruses pseudovirus pseudoviruses receptor released respiratory S protein S1 secretion S1 subunit SARS-CoV-2 SARS-CoV-2 pathogenesis SARS-CoV-2 S protein secrete sera severe acute respiratory syndrome Coronavirus shown Site Spike protein Spread spreading Syncytia syncytium syncytium formation the S protein the S1 subunit TLR4 TMPRSS2 TMPRSS2 expression variant Viral viral evolution viral evolution. virus virus entry virus spread [DOI] 10.1128/jvi.00753-22 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathwaySARS-CoV-2 Omicron은 세포 진입 경로가 변경된 면역 탈출 변종입니다.Article Published on 2022-08-012022-09-11 Journal: Nature Microbiology [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단, [키워드] Amino acid antigenicity B.1.1.529 BNT162b2 booster vaccination Cell cell entry Cell fusion ChAdOx1 changes in cornerstone COVID-19 described determined by Effectiveness endosomal entry endosomal entry pathway Immune escape Impaired in vitro increasingly individual induce mapped mRNA mRNA-1273 Mutation neutralization omicron Omicron variant Omicron variants pathogenicity pathway phenotype public health Receptor-binding domain reduction in Region replicative restored S2 domain SARS-CoV-2 sera Spike protein Spread Syncytia the receptor-binding domain the spike protein These data TMPRSS2 transmissible variant underlie Vaccine variant VoC VOCs was determined [DOI] 10.1038/s41564-022-01143-7 PMC 바로가기 [Article Type] Article
Immunopathological changes, complications, sequelae and immunological memory in COVID-19 patientsReview article Published on 2022-04-262022-10-05 Journal: Heliyon [Category] 변종, 유전자 메커니즘, [키워드] ACE2 ACE2 protein ACE2 receptor antibody binding Care cell death changes Complication complications Confirmed COVID-19 COVID-19 patient COVID-19 patients death disease elevated evaluated expressed Health Immunity immunological change Immunological memory immunopathology increased risk Inflammation long-term health problem lung tissue major organs majority management Mild moderate multiple organ multiple organs Organ failure Pathogenesis prevalent problem reached receptor reduced Reinfection risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus sequelae severe complication Survivors susceptibility Symptoms Syncytia vaccination [DOI] 10.1016/j.heliyon.2022.e09302 [Article Type] Review article
Virus-Induced Membrane Fusion in Neurodegenerative DisordersArticle Published on 2022-03-242023-06-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, [키워드] cellular senescence fusion HERVs Syncytia virus [DOI] 10.3389/fcimb.2022.845580 PMC 바로가기
Novel Hendra Virus Variant Detected by Sentinel Surveillance of Horses in AustraliaArticle Published on 2022-03-012023-08-30 Journal: Emerging Infectious Diseases [Category] E형 간염, [키워드] Central nervous system Hendra henipavirus Hendra virus horse diseases meningitis/encephalitis one health PCR RNA sequencing sentinel species sentinel surveillance Syncytia Syndromic surveillance transdisciplinary research Vasculitis viral encephalitis viruses whole-genome sequencing zoonoses [DOI] 10.3201/eid2803.211245 PMC 바로가기
A new screening system for entry inhibitors based on cell-to-cell transmitted syncytia formation mediated by self-propagating hybrid VEEV-SARS-CoV-2 repliconCoronaviruses Published on 2022-02-042022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, COVID19(2023년), SARS, [키워드] addition antiserum Antiviral agents biosafety BSL-2 laboratory BSL-3 facility Cell COVID-19 Critical dose-dependent Entry inhibitor entry inhibitors events Evidence GFP Increasing inhibitor inhibitors live SARS-CoV-2 pathway performed positive Protein reporter vector responsible SARS-CoV-2 seeking Severe case shown spike Syncytia syncytia formation syncytium formation the S protein Transmission transmission rate transmitted Treatment VEEV Venezuelan equine encephalitis viral spike virus [DOI] 10.1080/22221751.2022.2030198 PMC 바로가기 [Article Type] Coronaviruses
Computationally prioritized drugs inhibit SARS-CoV-2 infection and syncytia formation계산 우선 순위 화 약물은 SARS-COV-2 감염 및 Syncytia 형성을 억제합니다Case Study Published on 2022-01-272022-09-10 Journal: Briefings in Bioinformatics [Category] 변종, 신약개발, 치료제, [키워드] 7-hydroxystaurosporine anti-inflammatory strategy Antiviral effect bafetinib candidate candidate drug candidate drugs compounds computational approach computational method Computational methods COVID-19 COVID-19 pandemic data-driven de novo delta variant drug drug design drug repositioning drugs effective effective drugs help human cell human cells in vitro Infection information inhibit inhibit SARS-CoV-2 kinase inhibitors list pharmacological SARS-CoV-2 selected subset Syncytia syncytia formation synergistic Treatment treatment of COVID-19 vaccination viral-induced Virtual screening [DOI] 10.1093/bib/bbab507 PMC 바로가기 [Article Type] Case Study
Molecular mechanisms for understanding the association between TMPRSS2 and beta coronaviruses SARS-CoV-2, SARS-CoV and MERS-CoV infection: scoping reviewTMPRSS2와 베타 코로나바이러스 SARS-CoV-2, SARS-CoV 및 MERS-CoV 감염 간의 연관성을 이해하기 위한 분자 메커니즘: 범위 검토Review Published on 2021-12-252022-09-11 Journal: Archives of Microbiology [Category] SARS, 유전자 메커니즘, [키워드] ACE2 Activation association beta coronavirus beta-CoVs Betacoronavirus cell surface receptor cell surface receptors CENTRAL cleaved Controlled controlled trials Critical DPP4 Evidence Gene host cells identify in viral infected cells Infection involved knowledge mechanism membrane fusion MERS MERS-CoV molecular molecular mechanism molecular mechanisms mRNA OVID Pathogenesis protease Protein Replication Research SARS-CoV SARS-CoV-2 searched Serine serine protease spike Spike protein Spread Syncytia the Spike TMPRSS2 TMPRSS2. virus entry virus propagation virus replication [DOI] 10.1007/s00203-021-02727-3 PMC 바로가기 [Article Type] Review
Multicenter study evaluating one multiplex RT-PCR assay to detect SARS-CoV-2, influenza A/B, and respiratory syncytia virus using the LabTurbo AIO open platform: epidemiological features, automated sample-to-result, and high-throughput testingLabturbo AIO Open 플랫폼을 사용하여 SARS-COV-2, 인플루엔자 A/B 및 호흡기 넥시 티아 바이러스를 검출하기위한 하나의 멀티 플렉스 RT-PCR 분석을 평가하는 다중 센터 연구 : 역학 기능, 자동화 된 샘플 대 레지 포트 및 고 처리량 테스트Multicenter Study Published on 2021-12-152022-09-01 Journal: Aging (Albany NY) [Category] SARS, 변종, 진단, 치료기술, [키워드] analytical sensitivity applied automated B.1.1.7 B.1.1.7 variant clinical sample clinical samples Cluster Co-infection coronavirus COVID-19 COVID-19 pandemic Decision making demonstrated detect Diagnosis diagnostic disease epidemiological evaluate Features increased mortality Influenza influenza A molecular multicenter multicenter study multiplex multiplex testing Nasopharyngeal swab occur open pandemic patients PCR performed platform provided reported respiratory respiratory syncytial virus respiratory virus risk robust RSV RT-PCR RT-PCR assay SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 VoC sensitivity Syncytia The B.1.1.7 Transmission Treatment turnaround times variant virus viruses VoC [DOI] 10.18632/aging.203761 PMC 바로가기 [Article Type] Multicenter Study