ENDOTHELIAL GLYCOCALYX SHEDDING IN INTRA-ABDOMINAL SEPSIS: A FEASIBILITY STUDYArticle Published on 2024-06-232024-09-05 Journal: Shock (Augusta, Ga.) [Category] update2024, [키워드] glycocalyx Hyaluronan peritoneum tissue Sepsis Syndecan-1 [DOI] 10.1097/SHK.0000000000002079 PMC 바로가기 [Article Type] Article
The utility of syndecan-1 circulating levels as a biomarker in patients with previous or active COVID-19: a systematic review and meta-analysisarticle Published on 2023-08-042024-09-05 Journal: BMC Infectious Diseases [Category] update2024, [키워드] COVID-19 Diagnosis glycocalyx Meta-analysis Prognosis Syndecan-1 systematic review [DOI] 10.1186/s12879-023-08473-9 PMC 바로가기 [Article Type] article
Yellow fever disease severity and endothelial dysfunction are associated with elevated serum levels of viral NS1 protein and syndecan-1Article Published on 2023-06-302024-09-05 Journal: medRxiv [Category] update2024, [키워드] Endothelial dysfunction NS1 Pathogenesis Syndecan-1 yellow fever [DOI] 10.1101/2023.06.29.23292053 PMC 바로가기 [Article Type] Article
Vascular Endothelial Glycocalyx Damage and Potential Targeted Therapy in COVID-19Review Published on 2022-06-192023-07-09 Journal: Cells [Category] COVID19(2023년), [키워드] COVID-19 endothelial cells glycocalyx Heparanase Syndecan-1 [DOI] 10.3390/cells11121972 PMC 바로가기 [Article Type] Review
The effect of prostacyclin infusion on markers of endothelial activation and damage in mechanically ventilated patients with SARS-CoV-2 infectionSARS-CoV-2 감염이 있는 기계 환기 환자의 내피 활성화 및 손상 마커에 대한 프로스타사이클린 주입의 효과Randomized Controlled Trial Published on 2022-06-012022-09-11 Journal: Journal of critical care [Category] COVID19(2023년), SARS, 바이오마커, 임상, [키워드] Activation Adult patients baseline Biomarker Biomarkers blood sample Blood samples CD40L change changes in collected COVID-19 damage decrease endothelial Endothelium glycocalyx groups marker mechanically ventilated mechanically ventilated patient mechanically ventilated patients median medians not differ Organ failure P-selectin Patient pilot study Placebo placebo group plasma Plasma levels prostacyclin protective effect Randomized Randomized controlled trial reduction in SARS-CoV-2 SARS-COV-2 infection selectin significantly syndecan Syndecan-1 the placebo group thrombomodulin with COVID-19 [DOI] 10.1016/j.jcrc.2022.154010 PMC 바로가기 [Article Type] Randomized Controlled Trial
Endothelial glycocalyx degradation in multisystem inflammatory syndrome in children related to COVID-19COVID-19와 관련된 어린이의 다기관 염증 증후군에서 내피 글리코칼릭스 분해Article Published on 2022-05-012022-09-11 Journal: Journal of Molecular Medicine (Berlin, Germany) [Category] MERS, 바이오마커, [키워드] acute respiratory syndrome Admission Adult patients affecting Biomarker Blood children children with MIS-C chondroitin chondroitin sulfate collected Complication Concentration controls coronavirus coronavirus disease Coronavirus disease 2019 correlated COVID-19 Cytokines Degradation Deterioration disease severity elevated endothelial Endothelial dysfunction Endothelium Future glycocalyx healthy hemodynamic heparan sulfate Infection Inflammation Inflammatory Injury intensive care lead marker MIS-C myocardial injury Necrosis Patient Potential biomarker potential biomarkers Predictive proinflammatory cytokines respiratory severe acute respiratory syndrome Coronavirus severe COVID-19 severity Shock suggested sulfate Support syndecan Syndecan-1 syndrome TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α Urine vasopressors [DOI] 10.1007/s00109-022-02190-7 PMC 바로가기 [Article Type] Article
Association between plasma glycocalyx component levels and poor prognosis in severe influenza type A (H1N1)Article Published on 2022-01-072022-10-04 Journal: Scientific Reports [Category] 바이오마커, 신종인플루엔자, [키워드] 28-day mortality acute lung injury Admission albumin levels Analysis APACHE II association blood sample cause Clinical data collected component contribute correlated Cutoff demonstrated determine disease severity Diseases Disruption endothelial Factor H1N1 H1N1 influenza healthy control hospital indicated Influenza influenza A influenza type A interleukin-6 Lactate mild cases organ dysfunction Patient patients with influenza plasma poor prognosis positively correlated Predictive Predictive markers prospective observational study sensitivity Sepsis severity significantly higher SOFA score specificity survival Syndecan-1 tumor necrosis factor-α viral infection virus infection were measured [DOI] 10.1038/s41598-021-04146-2 PMC 바로가기 [Article Type] Article
Syndecan-1, an indicator of endothelial glycocalyx degradation, predicts outcome of patients admitted to an ICU with COVID-19내피 글리코칼릭스 분해의 지표인 신데칸-1, 코로나19로 중환자실에 입원한 환자의 결과 예측Research Article Published on 2021-12-032022-09-10 Journal: Molecular Medicine [Category] SARS, 바이오마커, [키워드] analyzed association Biomarker Coagulopathy coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients Degradation demographic destruction develop endothelial endothelial damage Endothelial glycocalyx examined feasibility glycocalyx greater ICU increased mortality indicated Inflammation inflammatory reactions intensive care intensive care unit interleukin interleukin-6 investigated Kaplan–Meier survival analysis laboratory data log-rank test marker median Mortality non-survivor not significantly different outcome Patient Potential treatment predict progression Protecting Result serum severity of COVID-19 significantly higher supplementary material survival survival analysis survivor Survivors syndecan Syndecan-1 thrombomodulin Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α two group Variation with COVID-19 Wuhan Wuhan, China [DOI] 10.1186/s10020-021-00412-1 PMC 바로가기 [Article Type] Research Article
Brain injury, endothelial injury and inflammatory markers are elevated and express sex-specific alterations after COVID-19COVID-19 이후 뇌 손상, 내피 손상 및 염증 마커가 증가하고 성별에 따른 변화를 나타냅니다.Research Published on 2021-11-272022-09-10 Journal: Journal of Neuroinflammation [Category] MERS, 바이오마커, [키워드] affected alteration Analysis analyzed association bioinformatics Bioinformatics analysis Brain brain injury chemokine chemokines Control controls COVID-19 COVID-19 cohort COVID-19 hospitalization Cytokines disease severity EIM elevated endothelial injury Express expressed GFAp IL10 IL15 IL1RA IL8 immune response Inflammation Inflammatory Inflammatory cytokine Inflammatory marker inflammatory markers Injury investigated IP10 male MAP2 marker matched controls MCP1 men Mortality multiplex objective organ positive profile respiratory Respiratory disease Result risk robust S100B SARS-CoV-2 Seven Sex sex differences significantly subject supplementary material susceptible syndecan Syndecan-1 TNFα were used women [DOI] 10.1186/s12974-021-02323-8 PMC 바로가기 [Article Type] Research
Indications of Persistent Glycocalyx Damage in Convalescent COVID-19 Patients: A Prospective Multicenter Study and HypothesisObservational Study Published on 2021-11-212022-10-04 Journal: Viruses [Category] MERS, 임상, 치료기술, [키워드] analyzed caused controls convalescent COVID-19 patient convalescent COVID-19 patients convalescent patient Course COVID-19 COVID-19 infection COVID-19 pandemic Critical disease cross-sectional damage Degradation demonstrated disease disease course Disease progression elevated Endothelial cell endothelial damage Evidence glycocalyx healthy controls healthy individual Hospitalization hospitalized COVID-19 patient hospitalized patient hyperinflammation indication infected with SARS-CoV-2 Injury long-COVID-19 lung damage median Mild multicenter multicenter study no difference parameter persistent progression Prospective SARS CoV-2 SARS-CoV-2 significantly symptom onset Syndecan-1 virus with mild disease [DOI] 10.3390/v13112324 PMC 바로가기 [Article Type] Observational Study