Development of a synthetic library of humanized nanobodies for targeted IL-6 inhibitionarticle Published on 2024-07-232024-09-05 Journal: Frontiers in Bioengineering and Biotechnology [Category] update2024, [키워드] blocking antibody humanization interleukin-6 nanobody phage display stability synthetic library [DOI] 10.3389/fbioe.2024.1440150 PMC 바로가기 [Article Type] article
A VHH single-domain platform enabling discovery and development of monospecific antibodies and modular neutralizing bispecifics against SARS-CoV-2 variantsResearch Article Published on 2024-04-032024-09-05 Journal: Antibody Therapeutics [Category] update2024, [키워드] avidity multivalent neutralizing antibody omicron SARS-CoV-2 synthetic library tetravalent bispecific VHH [DOI] 10.1093/abt/tbae009 PMC 바로가기 [Article Type] Research Article
Single-domain antibodies against SARS-CoV-2 RBD from a two-stage phage screening of universal and focused synthetic librariesResearch Published on 2024-02-132024-09-05 Journal: BMC Infectious Diseases [Category] update2024, [키워드] phage display RBD SARS-CoV-2 single-domain antibody synthetic library [DOI] 10.1186/s12879-024-09022-8 PMC 바로가기 [Article Type] Research
Facile isolation of high-affinity nanobodies from synthetic libraries using CDR-swapping mutagenesisCDR 스와핑 돌연변이 유발을 사용하여 합성 라이브러리에서 고친화성 나노바디를 쉽게 분리Comment Published on 2022-01-202022-09-11 Journal: STAR protocols [Category] SARS, 변종, [키워드] Affinity maturation antibody approach bioengineering Biotechnology Biotechnology and bioengineering CDR CDRs Cell Biology complementarity-determining region Complete expression Flow flow cytometry Flow Cytometry/Mass Cytometry immunization Isolation Molecular biology Mutagenesis nanobodies nanobody Neutralizing optimization Protein Biochemistry protein expression Protein expression and purification protocol purification SARS-CoV-2 sorting synthetic library variant [DOI] 10.1016/j.xpro.2021.101101 PMC 바로가기 [Article Type] Comment