The Role of the Immune System in the Course of Hashimoto’s Thyroiditis: The Current State of KnowledgeReview Published on 2024-06-232024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] Apoptosis B lymphocytes Hashimoto’s disease natural killer pyroptosis regulatory T cells T helper cells T lymphocytes [DOI] 10.3390/ijms25136883 PMC 바로가기 [Article Type] Review
Pneumococcal pep27-mutant inhibits Wnt5a expression via the regulation of T helper cells to attenuate colitisarticle Published on 2022-08-312024-09-01 Journal: International Immunopharmacology [Category] 폐렴구균 감염증, [키워드] immune tolerance Inflammatory bowel disease macrophages T helper cells Wnt signaling Δpep27 [Article Type] article
Conjugation with 8-arm PEG and CRM 197 enhances the immunogenicity of SARS-CoV-2 ORF8 protein8-arm PEG 및 CRM 197과의 접합은 SARS-CoV-2 ORF8 단백질의 면역원성을 향상시킵니다Article Published on 2022-08-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 변종, [키워드] activate adjuvant adjuvants aluminum antigens BALB/c mice carrier protein cellular conjugate Conjugates conjugation COVID-19 pandemic CRM(197) cytokine Cytokines effective effective vaccine Effective vaccines Effectiveness eight-arm PEG. ENhance evaluated expected functions humoral immune response IFN-β IFN-γ IgG IL-5 immune protection immune response immune responses immunogenicity IMPROVE inherent inhibit liver multiple antigen ORF8 ORF8 protein proliferation promoter Protein raise renal SARS-CoV-2 SARS-CoV-2 antigen SARS-CoV-2 vaccine SARS-CoV-2 variants splenocyte T helper cell T helper cells the SARS-CoV-2 TNF-α Toxicity Vaccine Vaccines variant [DOI] 10.1016/j.intimp.2022.108922 PMC 바로가기 [Article Type] Article
Transient and durable T cell reactivity after COVID-19COVID-19 이후 일시적이고 지속적인 T 세포 반응성Article Published on 2022-07-262022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analyzed Antigen antigens Cell convalescent patient Convalescent patients coronavirus correlated COVID-19 cytokine Cytokines determine Ex vivo followed by IL-12 IL-13 IL-17 IL-2 Infection interferon interferon-γ interleukin long-lasting Longevity median N-terminal nucleocapsid protein Patient peptide peptides Polarity Protein reactivity remained respiratory retrieved SARS-CoV-2 severe acute respiratory syndrome Coronavirus stimulated synchronous T cell T cell cytokines T cell memory T helper T helper cells Transient triggered whole blood sample [DOI] 10.1073/pnas.2203659119 PMC 바로가기 [Article Type] Article
Helminth antigens differentially modulate the activation of CD4 + and CD8 + T lymphocytes of convalescent COVID-19 patients in vitro기생충 항원은 시험관 내에서 회복기 COVID-19 환자의 CD4 + 및 CD8 + T 림프구의 활성화를 차등적으로 조절합니다Article Published on 2022-06-282022-09-11 Journal: BMC Medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Activation activation markers. addition African age analyzed Antigen antigens Ascaris lumbricoides Brugia malayi caused CD137 CD137 (4-1BB) CD4 CD4+ CD4+ helper and CD8+ T cytotoxic T cells CD69 CD8 CD8+ cell culture supernatants cell-mediated immune response convalescent COVID-19 patient coronavirus coronavirus disease Coronavirus disease 2019 country Course COVID-19 COVID-19 patient COVID-19 patients cytokine expression Cytotoxic T cell Cytotoxic T cells death Disease progression Effect Endemic evade expression Factors flow cytometry Frequency genetics helminth Helminth antigens helper human immune response Hypothesis IFN-γ IFNγ IL-10 IL-6 immune immune reactivity immune responses in vitro incidence of COVID-19 investigated mechanisms moderate modulate MONITOR Mortality not affected offer Onchocerca volvulus pandemic parasites PBMC PBMCs peptides Prevalence reactivity reduced reduction remained Respiratory disease SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 transmission significantly significantly increased Spread Stimulation sub-Saharan Africa Support suppress T cell T cell response T cells T helper cells T lymphocyte TNFα Vaccines virus was measured were used [DOI] 10.1186/s12916-022-02441-x PMC 바로가기 [Article Type] Article
The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection세포 면역의 견고함이 SARS-CoV-2 감염의 운명을 결정합니다Review Published on 2022-06-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] addition Administered Analysis antibody secreting cells antiviral cytokine antiviral cytokines antiviral immunity antiviral response appearance approach autosomal recessive axis B cell booster dose breadth CD4+ CD4+ T cell CD8+ Cell cellular Cellular immune response cellular immunity component contribute coordinating correlated COVID-19 COVID-19 patient Critical cross-protection Cytokines cytotoxic lymphocytes cytotoxic T lymphocytes described disease Disease progression disease severity dysregulated evasion Evolution follicular functional Germinal center global pandemic greater helper T cells humoral IFN-γ immune protection immune system Immunity in some infected cells Infection infection control inflammatory cascade innate immune system killing knowledge long-lasting lymphocyte Lymphocytes magnitude memory modulating neutralizing antibody pathogenic inflammation phenotypic pro-inflammatory cytokine pro-inflammatory cytokines protective immunity reported responsible robustness SARS-CoV-2 SARS-CoV-2 virus secreting severe COVID-19 severity Stage stages T cell T cell response T cell responses T cells T helper cell T helper cells Tfh Tfh cells the SARS-CoV-2 virus thought TNF-α vaccination Vaccine viral replication X-linked [DOI] 10.3389/fimmu.2022.904686 PMC 바로가기 [Article Type] Review
Immunomodulatory effects of Andrographis paniculata extract in healthy adults – An open-label studyOriginal Research Article (Clinical) Published on 2021-08-082024-09-04 Journal: Journal of Ayurveda and Integrative Medicine [Category] 대상포진, [키워드] Andrographis paniculata Immunity interferon gamma interleukin-2 Interleukin-4 T cells T helper cells [DOI] 10.1016/j.jaim.2021.06.004 PMC 바로가기 [Article Type] Original Research Article (Clinical)
COVID-19 Severity in Obesity: Leptin and Inflammatory Cytokine Interplay in the Link Between High Morbidity and MortalityImmunology Published on 2021-06-182022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress adaptive adipocyte adipose antigen-presenting cells Autoimmune disorders characteristic circulating contribute Coordinate Coronavirus infection COVID-19 COVID-19 patient cytokine cytokine secretion death Diseases dysregulation Fat mass function high mortality rate IL-2 IL-6 immune response Immunity Impact increase in Inflammation inflammatory condition Inflammatory cytokine Inflammatory responses Leptin long-lasting mechanism Monocytes Mortality obesity outcome pandemic progresses Patient patients with obesity plasma pleiotropic Pneumonia pro-inflammatory cytokine proliferation proportion response resulting risk factor SARS-COV-2 infection secretion severity susceptibility syndrome T helper cells Th1 the disease These cells tissue TNF-α [DOI] 10.3389/fimmu.2021.649359 PMC 바로가기 [Article Type] Immunology
Broad Severe Acute Respiratory Syndrome Coronavirus 2 Cell Tropism and Immunopathology in Lung Tissues From Fatal Coronavirus Disease 2019광범위한 중증 급성 호흡기 증후군 코로나바이러스 2 치명적인 코로나바이러스 질병 2019에서 폐 조직의 세포 친화성 및 면역병리학Article Published on 2021-06-042022-09-11 Journal: The Journal of Infectious Diseases [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 ACE2-positive cell Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptive alveolar alveolar damage angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Autopsy B cell B cells Cell cell tropism cells ciliated contributing to coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Cytotoxic T cells DAD Depletion Diffuse alveolar damage endothelial cells excessive inflammation exhibited expression fatal COVID-19 goblet IL-6 immune cells immune responses immunofluorescence immunofluorescence assay immunohistochemistry Immunosuppression infected cell infected cells Infection infiltrating immune cell infiltrating immune cells Inflammation inflammatory cell inflammatory cells Innate immune cells interleukin-6 Lineage lung lung parenchyma Lungs macrophages marker mechanism Monocytes MOST natural killer Neutrophils NK cells Patient performed positive Protein pulmonary symptom pulmonary symptoms reflected regulatory T cells respiratory SARS-CoV-2 SARS-CoV-2 cell severe acute respiratory syndrome Coronavirus staining T cell T cells T helper cells thromboemboli. Thromboembolism tissue tissue damage to define tropism Viral viral infection Viral protein Viral proteins viral tropism [DOI] 10.1093/infdis/jiab195 PMC 바로가기 [Article Type] Article
Clinical characteristics, treatment, and prognosis of 74 2019 novel coronavirus disease patients in Hefei: A single-center retrospective study허페이의 2019년 신종 코로나바이러스 감염증 환자 74명의 임상적 특징, 치료 및 예후: 단일 센터 후향적 연구Comparative Study Published on 2021-05-282022-09-11 Journal: Medicine [Category] SARS, 치료제, [키워드] 2019 novel coronavirus Admission C-reactive protein C-reactive protein (CRP caused CD4/CD8 Characteristics China clinical Clinical characteristics Clinical data collected Computed tomography coronavirus disease cough COVID-19 COVID-19 patient COVID-19 patients Cytotoxic T cell Cytotoxic T cells disease epidemiological Epidemiology erythrocyte sedimentation erythrocyte sedimentation rate ESR expectoration fatigue followed by Hospitalization hospitalized patient ICU ICU patient ICU Patients Incubation period Inflammatory indicators intensive care intensive care unit Laboratory much higher non-ICU non-ICU patient non-ICU patients Novel coronavirus novel coronavirus disease nucleic acid Patient patients Pneumonia Prognosis proportion pulmonary computed tomography radiological Retrospective study SARS-CoV-2 sedimentation rate significantly higher single-center Spread Symptom symptom onset symptoms of infection T cells T helper cell T helper cells tested the median transmission of SARS-CoV-2 Treatment viral nucleic acid Wuhan [DOI] 10.1097/MD.0000000000025645 PMC 바로가기 [Article Type] Comparative Study