A systematic review and meta-analysis, investigating dose and time of fluvoxamine treatment efficacy for COVID-19 clinical deterioration, death, and Long-COVID complicationsArticle Published on 2024-06-122024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] (E)‐5‐methoxy‐1‐[4‐(trifluoromethyl)phenyl]pentan‐1‐one O‐2‐aminoethyl oxime) antidepressant coronavirus Disease prevention Drug repurposing Drug safety Infectious diseases Neurochemistry Neurological disorders pandemic Pharmacology Psychiatric disorders public health Respiratory tract diseases SARS-CoV-2 Sigma-1 receptor (σ1R) Target identification Therapeutics viral infection [DOI] 10.1038/s41598-024-64260-9 PMC 바로가기 [Article Type] Article
Alpha and gamma mangostins inhibit wild-type B SARS-CoV-2 more effectively than the SARS-CoV-2 variants and the major target is unlikely the 3C-like proteaseResearch Article Published on 2024-05-272024-09-05 Journal: Heliyon [Category] update2024, [키워드] 3C-like protease Alpha mangostin antiviral drug discovery COVID-19 drug Gamma mangostin SARS-CoV-2 drugs Target identification [DOI] 10.1016/j.heliyon.2024.e31987 PMC 바로가기 [Article Type] Research Article
Mechanistic insights into SARS-CoV-2 spike protein induction of the chemokine CXCL10Article Published on 2024-05-162024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] biomedical engineering CXCL10 (IP-10) Glycogen synthase kinase-3 IRF NF-κB SARS-CoV-2-Spike Protein Target identification TLR2 viral infection [DOI] 10.1038/s41598-024-61906-6 PMC 바로가기 [Article Type] Article
Network analysis-guided drug repurposing strategies targeting LPAR receptor in the interplay of COVID, Alzheimer’s, and diabetesArticle Published on 2024-02-212024-09-05 Journal: Scientific Reports [Category] update2024, [키워드] Alzheimer’s diseases COVID-19 Diabetes Mellitus docking Drug discovery LPAR Lupron Molecular medicine NEUROLOGY neuroscience Target identification [DOI] 10.1038/s41598-024-55013-9 PMC 바로가기 [Article Type] Article
Promising antimalarial hits from phenotypic screens: a review of recently-described multi-stage actives and their modes of actionarticle Published on 2023-12-312024-09-01 Journal: Frontiers in Cellular and Infection Microbiology [Category] 말라리아, [키워드] antimalarial mode of action phenotypic screening Plasmodium falciparum Target identification [Article Type] article
Promising antimalarial hits from phenotypic screens: a review of recently-described multi-stage actives and their modes of actionCellular and Infection Microbiology Review Published on 2023-12-152024-09-05 Journal: Frontiers in Cellular and Infection Microbiology [Category] update2024, [키워드] antimalarial mode of action phenotypic screening Plasmodium falciparum Target identification [DOI] 10.3389/fcimb.2023.1308193 PMC 바로가기 [Article Type] Cellular and Infection Microbiology Review
Chemo-proteomics in antimalarial target identification and engagementarticle Published on 2023-11-302024-09-01 Journal: Medicinal Research Reviews [Category] 말라리아, [키워드] antimalarial chemical probe malaria target engagement Target identification [Article Type] article
Chronic cough relief by allosteric modulation of P2X3 without taste disturbancearticle Published on 2023-09-202024-09-05 Journal: Nature Communications [Category] update2024, [키워드] Drug discovery Ligand-gated ion channels molecular biophysics Target identification [DOI] 10.1038/s41467-023-41495-0 PMC 바로가기 [Article Type] article
Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infectionarticle Published on 2023-09-182024-09-05 Journal: Nature Communications [Category] update2024, [키워드] Innate immunity Target identification viral infection [DOI] 10.1038/s41467-023-41381-9 PMC 바로가기 [Article Type] article
Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targetsarticle Published on 2023-09-132024-09-05 Journal: Nature Communications [Category] update2024, [키워드] structural biology Target identification Viral proteins [DOI] 10.1038/s41467-023-41312-8 PMC 바로가기 [Article Type] article