Are MUC5B and TERT mutations genetic risk factors for pulmonary fibrosis in individuals with severe COVID-19?Research Article Published on 2023-03-102024-09-05 Journal: Tüberküloz ve toraks [Category] update2024, [키워드] MUC5B polymorphism SARS-CoV-2 TERT [DOI] 10.5578/tt.20239905 PMC 바로가기 [Article Type] Research Article
Generation of environmental persistent free radicals (EPFRs) enhances ecotoxicological effects of the disposable face mask waste with the COVID-19 pandemic환경 지속성 자유 라디칼(EPFR)의 생성은 COVID-19 전염병으로 일회용 안면 마스크 폐기물의 생태독성 효과를 향상시킵니다Article Published on 2022-05-152022-09-11 Journal: Environmental pollution (Barking, Essex : 1987) [Category] COVID19(2023년), SARS, 치료기술, [키워드] acetophenone acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 BENZOTHIAZOLE bisphenol butylphenol carbon characteristic contribute coronavirus COVID-19 COVID-19 pandemic cytotoxicity dominant dramatic increase Effect ENhance Environmentally persistent free radicals (EPFRs) exposure to Face mask free radical generate Generation Health risk Heavy metals higher risk highlight in vitro Leachate Mask microplastics Microplastics (MPs) mixture N95 respirator N95 respirators oxidative stress oxygen pandemic phthalide plastic Plastic face masks (DPFs). plasticizer Polypropylene produced risk Risk assessment SARS-CoV-2 severe acute respiratory syndrome Coronavirus solvent surgical TERT tested toxic effects Toxicity water [DOI] 10.1016/j.envpol.2022.119019 PMC 바로가기 [Article Type] Article
Molecular Mechanisms of Alveolar Epithelial Stem Cell Senescence and Senescence-Associated Differentiation Disorders in Pulmonary Fibrosis폐 섬유증에서 폐포 상피 줄기 세포 노화 및 노화 관련 분화 장애의 분자 기전Review Published on 2022-03-032022-09-11 Journal: Cells [Category] MERS, SARS, 유전자 메커니즘, 진단, [키워드] accelerated alveolar caused Cell cell senescence cellular senescence COVID-19 Degradation developmental differentiation disorder disrupt DNA damage DNA damage response dysfunction epithelial fibrosis followed by framework Idiopathic pulmonary fibrosis induce inhibiting inhibitor Intervention IPF low-grade inflammation mechanism molecular mechanism molecular mechanisms OIS oncogene pathway Premature Protein pulmonary pulmonary fibrosis replicative replicative senescence reported reverse transcriptase RNA SARS-CoV-2 viral infection senescence senescent cell senescent cells STEM stem cell suppression susceptibility telomerase telomerase and telomeres. telomeres TERC TERT TGF TGF-β TGF-β signalling TPP1 transcriptase Viral viral infection [DOI] 10.3390/cells11050877 PMC 바로가기 [Article Type] Review
SBSA: an online service for somatic binding sequence annotationSBSA: 체세포 결합 시퀀스 주석을 위한 온라인 서비스Article Published on 2022-01-112022-09-11 Journal: Nucleic Acids Research [Category] 변종, 유전자 메커니즘, [키워드] alteration approach binding Cancer cells candidate cause demonstrated efficient ETS1 Genome genomic variant genomic variants help hypotheses identify joint mechanism miRNA molecular Mutation nucleotide offer online tool Organisms polymorphism promoter region Proteins reference genome RNA sequence sequences single nucleotide Single nucleotide polymorphism Somatic somatic mutation subjects Support TERT TFS therapeutic transcription factor transcription factors variants [DOI] 10.1093/nar/gkab877 PMC 바로가기 [Article Type] Article
A Potent Leukocyte Transmigration Blocker: GT-73 Showed a Protective Effect against LPS-Induced ARDS in Mice강력한 백혈구 변환 차단제 : GT-73은 마우스에서 LPS- 유도 된 ARD에 대한 보호 효과를 나타냈다.Article Published on 2021-07-292022-08-31 Journal: Molecules [Category] SARS, 바이오마커, [키워드] acute respiratory distress acute respiratory distress syndrome addition Adhesion Molecule affecting applied ARDS BALF bind biochemical blocked blocker Blood blood cell Bronchoalveolar lavage fluid caused cell adhesion molecule covalent inhibitor COVID-19 patient COVID-19 patients Critical Cytokine storm derivatives drug candidate Effect Endothelial cell evaluate finding histological IL-1β IL-6 infiltrating Inflammation investigated leukocyte leukocyte transmigration leukocytes lung Lungs MCP-1 Migration molecule Mortality mouse model PECAM-1 peripheral tissues Platelet potent prodrug rationale reduced respiratory distress Respiratory distress syndrome responsible Showed significantly syndrome TERT transendothelial migration transmigration Treatment unique was tested was used White blood cell [DOI] 10.3390/molecules26154583 PMC 바로가기 [Article Type] Article
Age-Dependent Assessment of Genes Involved in Cellular Senescence, Telomere, and Mitochondrial Pathways in Human Lung Tissue of Smokers, COPD, and IPF: Associations With SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 AxisPharmacology Published on 2020-09-092022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] acute respiratory syndrome age aging alteration Analysis analyzed assessment association attrition axis CDKN1C cellular senescence chronic obstructive chronic obstructive pulmonary diseases contribute COPD coronavirus COVID-19 COX10 COX18 differentially expressed DNA damage DPP4 ERCC1 Factor FEN1 FIS1 furin GADD45A GADD45B Gene Expression HAT1 HSPD1 Human human lung tissue Idiopathic pulmonary fibrosis immunoblot Infection Infectious disease Inflammatory IPF lung Lung diseases mechanism Mitochondria mitochondrial Mitochondrial function NBN NFATC1 NOX4 Older PARP1 Patient patients PCNA pharmacological target platform processed progression protease Protein PTEN pulmonary disease pulmonary fibrosis Quality control RAD17 receptor ACE2 regulate Result RHOT2 RNA SARS-CoV-2 senescence SIRT6 slight increase SLX4 Smokers subject subjects target gene Target genes telomere TERT the SARS-CoV-2 TMPRSS2 TNKS2 Total Transcription UCP2 [DOI] 10.3389/fphar.2020.584637 PMC 바로가기 [Article Type] Pharmacology
Studies on the correlation between mutation and integration of HBV in hepatocellular carcinomaArticle Published on 2020-08-282023-06-02 Journal: Bioscience Reports [Category] B형 간염, [키워드] HBV HBV integration HCC SNV TERT [DOI] 10.1042/BSR20201988 PMC 바로가기
Comprehensive review of Hepatitis B Virus-associated hepatocellular carcinoma research through text mining and big data analyticsArticle Published on 2019-04-012023-06-18 Journal: Biological Reviews of the Cambridge Philosophical Society [Category] B형 간염, [키워드] AKT/PI3K/MAPK chronic FN1 HBV HBx HCC integration Liver cancer TERT text-mining. [DOI] 10.1111/brv.12457
Telomerase reverse transcriptase promoter mutations in hepatitis B virus-associated hepatocellular carcinomaResearch Paper Published on 2016-05-102023-06-02 Journal: Oncotarget [Category] B형 간염, [키워드] Hepatocellular carcinoma Mutation telomerase reverse transcriptase TERT [DOI] 10.18632/oncotarget.8539 PMC 바로가기 [Article Type] Research Paper
Comprehensive analyses of mutations and hepatitis B virus integration in hepatocellular carcinoma with clinicopathological featuresArticle Published on 2016-05-012023-06-19 Journal: Journal of Gastroenterology [Category] B형 간염, [키워드] CTNNB1 TERT TP53. [DOI] 10.1007/s00535-015-1126-4