Tetravalent SARS-CoV-2 S1 subunit protein vaccination elicits robust humoral and cellular immune responses in SIV-infected rhesus macaque controllersarticle Published on 2023-10-132024-09-05 Journal: mBio [Category] update2024, [키워드] cellular immunity COVID-19 Efficacy Humoral immunity immunogenicity nonhuman primate Protein subunit SARS-CoV-2 tetravalent Vaccines [DOI] 10.1128/mbio.02070-23 PMC 바로가기 [Article Type] article
Preclinical evaluation of ISH0339, a tetravalent broadly neutralizing bispecific antibody against SARS-CoV-2 with long-term protectionResearch Article Published on 2023-04-062024-09-05 Journal: Antibody Therapeutics [Category] update2024, [키워드] bispecific COVID-19 ISH0339 long-protection Neutralizing omicron SARS-CoV-2 tetravalent [DOI] 10.1093/abt/tbad003 PMC 바로가기 [Article Type] Research Article
A highly efficacious live attenuated mumps virus-based SARS-CoV-2 vaccine candidate expressing a six-proline stabilized prefusion spike6-프롤린 안정화된 융합전 스파이크를 발현하는 매우 효과적인 약독화성 볼거리 바이러스 기반 SARS-CoV-2 백신 후보Article Published on 2022-08-162022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibody backbone candidate children COVID-19 vaccine Delta delta variant Delta variants effective expressed expressing expression Genome hamster human vaccine IFNAR1 immune responses Immunity immunization immunogenic Immunoglobulin immunoglobulin A include Infant Infants intranasal junction mice MMR MMR vaccine mucosal mump mumps virus neutralized Neutralizing antibodies neutralizing antibody prefusion proline prolines raised rapid increase Safe SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 USA-WA1/2020 SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants sera Spike protein T cell tetravalent Vaccine vaccine strain variants virus [DOI] 10.1073/pnas.2201616119 PMC 바로가기 [Article Type] Article
Peptide-Antibody Fusions Engineered by Phage Display Exhibit an Ultrapotent and Broad Neutralization of SARS-CoV-2 Variants파지 디스플레이가 조작한 펩티드-항체 융합은 SARS-CoV-2 변이체의 초강력 및 광범위한 중화를 나타냅니다Article Published on 2022-07-152022-09-11 Journal: ACS chemical biology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] affinities affinity approach approved B.1.1.529 Bivalent bivalent IgG breadth clinically Coverage COVID-19 demonstrated display domain dominant ENhance exacerbated fused fusion fusions generate implicated IMPROVE Infection infection assay low potency Mutation N-terminal domain N-terminus NAb NAbs naïve neutralization neutralization potency neutralize neutralizing antibody NTD omicron peptide peptides phage RBD RBD mutation RBD mutations S-protein SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein spread of COVID-19 tetravalent the RBD the spike protein therapeutic Therapeutics trimer variant variants variants of concern vulnerability [DOI] 10.1021/acschembio.2c00411 PMC 바로가기 [Article Type] Article
Trivalent NDV-HXP-S Vaccine Protects against Phylogenetically Distant SARS-CoV-2 Variants of Concern in Mice3가 NDV-HXP-S 백신은 마우스에서 계통 발생학적으로 멀리 떨어져 있는 SARS-CoV-2 변이체로부터 보호합니다Article Published on 2022-06-292022-09-11 Journal: Microbiology Spectrum [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Beta circulating combinations composed concern coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-neutralizing antibodies cross-neutralizing antibody cross-protection Delta delta variant described Distant effort Express expressing Gamma help immunogenicity increase limit low-cost vaccine platform manuscript mice multivalent vaccine Neutralizing Neutralizing antibodies newcastle disease virus omicron pandemic pandemic preparedness phylogenetically platform prefusion Previous studies respiratory SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants Spike protein Spike proteins stabilized spike protein tested tetravalent the spike protein trivalent Vaccine Vaccines variant variants vector virus VoC Wuhan [DOI] 10.1128/spectrum.01538-22 PMC 바로가기 [Article Type] Article
Ultrapotent and broad neutralization of SARS-CoV-2 variants by modular, tetravalent, bi-paratopic antibodies모듈러, 4가, 2중 파라토프 항체에 의한 SARS-CoV-2 변이체의 초강력 광범위 중화Article Published on 2022-05-312022-09-11 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] antibodies antibody approval bi-paratopic bind bispecific bivalent IgG breadth Characteristics chimeric clinically comparable Coverage COVID-19 CP: Immunology CP: Microbiology Emergency use exhibit format high potency IgGs immunology Microbiology mutational escape NAb NAbs neutralization neutralize neutralizes Neutralizing antibodies Passive immunotherapy platform pseudoviruses RBD robust S protein SARS-CoV-2 SARS-CoV-2 pseudoviruses SARS-CoV-2 spike protein SARS-CoV-2 variant Spike protein tetravalent the SARS-CoV-2 the spike protein therapeutic Treatment treatment of COVID-19 trimer variant variants variants of concern Viral viral variant virus virus variant. viruses [DOI] 10.1016/j.celrep.2022.110905 PMC 바로가기 [Article Type] Article
Two Different Therapeutic Approaches for SARS-CoV-2 in hiPSCs-Derived Lung OrganoidshiPSC에서 파생된 폐 오르가노이드에서 SARS-CoV-2에 대한 두 가지 다른 치료 접근 방식Article Published on 2022-04-052022-09-11 Journal: Cells [Category] COVID19(2023년), SARS, 바이오마커, 변종, [키워드] ACE2 airways alveolar approach approaches AT2 candidate Cell complex COVID-19 COVID-19 treatment develop dipeptidyl peptidase Dipeptidyl peptidase-4 distal DPP4 drugs Efficacy Efficiency evaluate Evidence Express expression of gene health emergency hiPSCs hLORGs homologous host cells human cells implicated in vitro in vivo Infection Inflammatory response Innate immunity lung modulation monoclonal Neutralizing neutralizing antibody neutralizing monoclonal antibody organ Organoid peptide pluripotent stem cell Protein proximal pseudovirus receptor receptors reducing reduction SARS-CoV-2 SARS-CoV-2 S SARS-CoV2 SARS-CoV2 pseudovirus spike Spike protein stem cells Structure synthetic peptide tested tetravalent therapeutic These data treated Treatment variant Viral viral entry were infected [DOI] 10.3390/cells11071235 PMC 바로가기 [Article Type] Article
A tetrameric ACE2 protein broadly neutralizes SARS-CoV-2 spike variants of concern with elevated potency사량체 ACE2 단백질은 상승된 효능으로 우려되는 SARS-CoV-2 스파이크 변이체를 광범위하게 중화합니다Article Published on 2021-10-012022-09-11 Journal: Antiviral Research [Category] SARS, 변종, 치료제, [키워드] ACE2 ACE2 protein ACE2-Fc addition Alpha Alpha variant angiotensin angiotensin converting enzyme B.1.1.7 B.1.351 Beta variant binding can not coronavirus COVID-19 dimeric elevated enzyme greater high affinity neutralization neutralize Pandemics Protein pseudotype virus SAR2-CoV-2 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 spike protein SARS-CoV-2 spike proteins SARS-CoV-2 spike variant SARS-CoV-2 variants South Africa spike Spike protein tetravalent the SARS-CoV-2 therapeutic approaches United Kingdom vaccination variant variant spike Variant spike. variants of concern VoC [DOI] 10.1016/j.antiviral.2021.105147 PMC 바로가기 [Article Type] Article
Tetravalent SARS-CoV-2 Neutralizing Antibodies Show Enhanced Potency and Resistance to Escape Mutations4가 SARS-CoV-2 중화 항체는 돌연변이 탈출에 대한 강화된 효능 및 내성을 보여줍니다Article Published on 2021-09-172022-09-11 Journal: Journal of Molecular Biology [Category] SARS, 변종, 진단, 치료제, [키워드] Anti-viral antibody antiviral therapies antiviral therapy approved avidity best binding site Bivalent COVID-19 drugs enhanced escape escape mutant host receptor Interaction magnitude mutants NAb NAbs Neutralizing Neutralizing antibodies potency produced promise Protein RBD-binding resistance S-protein SARS-CoV-2 show synthetic target tetravalent tetravalent. Therapeutics Threats Tolerance trimer variant Viral virus [DOI] 10.1016/j.jmb.2021.167177 PMC 바로가기 [Article Type] Article
Tetravalent Influenza Vaccine Is Not Associated With Neuroaxonal Damage in Multiple Sclerosis PatientsImmunology Published on 2021-08-262022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] addition Administered antibody production Antibody Response Antigen baseline both group changes in Cohort comparable controls COVID-19 criteria damage disease Disease activity fumarate HCs healthy control humoral immune response immunization increase in Influenza influenza vaccines investigated limit Multiple multiple sclerosis NfL objective Patient patients treated primary endpoint proportion Prospective Study radiological receiving Result sclerosis Seasonal influenza Seroconversion serum Strains tetravalent titers treated vaccination Vaccine [DOI] 10.3389/fimmu.2021.718895 PMC 바로가기 [Article Type] Immunology