Neutralization activity in chronic HIV infection is characterized by a distinct programming of follicular helper CD4 T cellsArticle Published on 2024-08-032024-09-05 Journal: bioRxiv [Category] update2024, [키워드] broadly neutralizing antibodies HIV Lymph node Tfh [DOI] 10.1101/2024.07.31.605954 PMC 바로가기 [Article Type] Article
Humoral and cellular immune responses to CoronaVac up to one year after vaccinationArticle Published on 2022-10-212022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] all subject Antibody Response Antiviral CD4^{+} T cell cellular Cellular immune response cellular response clinical trial CoronaVac cytokine production cytokine profile defined effector memory evaluated follicular humoral Humoral response immune immune memory immune response impacted Inactivated vaccine individual induce memory Older peaked Phase 3 response SARS-CoV-2 SARS-CoV-2-specific IgG SARS-CoV-2-specific immune responses second dose sustained T cell activation T cell phenotype Tfh Th2 vaccination vaccine dose vaccinees [DOI] 10.3389/fimmu.2022.1032411 PMC 바로가기
Adaptive immunity to SARS-CoV-2 infection: A systematic reviewArticle Published on 2022-10-102022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 바이오마커, [키워드] acute respiratory syndrome adaptive Adaptive immunity addressed Alpha Antigen article B cell Biomarker case-control study caused CD4+ T cell CD8+ CD8+ T lymphocytes Cell cell types Characteristics clinical benefits Cohort studies coronavirus coronavirus disease Course COVID-19 Critically ill Critically ill patient cross-sectional CXCL9 Cytokines database disease English Evidence experimental evidence follicular HLA-DR humoral Humoral immunity IL-10 IL-13 IL-15 IL-17 IL-1α IL-2 IL-21 IL-22 IL-23 IL-4 IL-5 IL-7 immune system Immunity immunological Immunological memory immunopathological in vitro assays individuals inflammatory mediator involved leukocyte Ligand lymphocyte marker mild case Necrosis poor prognosis predominant produced programmed cell death progression Protein Regulatory T cell responsible SARS-CoV-2 SARS-COV-2 infection SciELO secretion severity Spanish subpopulation systematic review T helper T helper cell T lymphocyte T-cell Response Tfh TGF-β Th1 Th17 Th2 the antibody the disease TNF-α Treg tumor growth Vaccine variable [DOI] 10.3389/fimmu.2022.1001198 PMC 바로가기
The Robustness of Cellular Immunity Determines the Fate of SARS-CoV-2 Infection세포 면역의 견고함이 SARS-CoV-2 감염의 운명을 결정합니다Review Published on 2022-06-272022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] addition Administered Analysis antibody secreting cells antiviral cytokine antiviral cytokines antiviral immunity antiviral response appearance approach autosomal recessive axis B cell booster dose breadth CD4+ CD4+ T cell CD8+ Cell cellular Cellular immune response cellular immunity component contribute coordinating correlated COVID-19 COVID-19 patient Critical cross-protection Cytokines cytotoxic lymphocytes cytotoxic T lymphocytes described disease Disease progression disease severity dysregulated evasion Evolution follicular functional Germinal center global pandemic greater helper T cells humoral IFN-γ immune protection immune system Immunity in some infected cells Infection infection control inflammatory cascade innate immune system killing knowledge long-lasting lymphocyte Lymphocytes magnitude memory modulating neutralizing antibody pathogenic inflammation phenotypic pro-inflammatory cytokine pro-inflammatory cytokines protective immunity reported responsible robustness SARS-CoV-2 SARS-CoV-2 virus secreting severe COVID-19 severity Stage stages T cell T cell response T cell responses T cells T helper cell T helper cells Tfh Tfh cells the SARS-CoV-2 virus thought TNF-α vaccination Vaccine viral replication X-linked [DOI] 10.3389/fimmu.2022.904686 PMC 바로가기 [Article Type] Review
TNF-α + CD4 + T cells dominate the SARS-CoV-2 specific T cell response in COVID-19 outpatients and are associated with durable antibodiesTNF-α + CD4 + T 세포는 COVID-19 외래 환자에서 SARS-CoV-2 특이적 T 세포 반응을 지배하고 내구성 항체와 관련이 있습니다Article Published on 2022-06-212022-09-11 Journal: Cell Reports Medicine [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] acute infection acute respiratory syndrome acute respiratory syndrome coronavirus Alpha antibodies antibody boost CD4 Cell Cohort coronavirus Coronavirus 2019 COVID-19 COVID-19 outpatient Cytokines enrolled feature IFNγ IL-21 Immunity Infection interferon gamma longitudinal maintenance mRNA mRNA vaccination NCT04331899 Necrosis Neutralizing antibodies neutralizing antibody percentage Post-infection predominant producing respiratory SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-neutralizing antibodies SARS-CoV-2-neutralizing antibody severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 T cell T cell response T cells Tfh the SARS-CoV-2 These data TNF-α Tumor tumor necrosis tumor necrosis factor tumor necrosis factor alpha [DOI] 10.1016/j.xcrm.2022.100640 PMC 바로가기 [Article Type] Article
Low-Dose SARS-CoV-2 S-Trimer with an Emulsion Adjuvant Induced Th1-Biased Protective Immunity저용량 SARS-CoV-2 S-삼량체(에멀젼 보조제 유도 Th1 편향 보호 면역 포함)Article Published on 2022-04-282022-09-11 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] ACE2 binding addition adjuvant alum aluminum aluminum hydroxide Antibody Response Antigen Antisera B cell B cells Beta binding affinity Cellular immune response clinical testing comparable Complete COVID-19 pandemic Delta demonstrated different dose different doses effective Efficacy Emulsion ENhance evaluated exhibit feasible follicular Germinal center herd immunity humoral immune response hydroxide immune responses Immunity immunogenicity induce induced Infection Lineage live SARS-CoV-2 low dose lower dose mass vaccination mice Mutation Neutralizing antibodies neutralizing antibody prefusion Prevent produced Protective protein subunit vaccine rodent rodents Safe SARS-CoV-2 Subunit vaccine Support sustained SWE T-cell T-cell responses T-cells Tfh the antibody response These data trimer utility vaccination Vaccinations Vaccine variant variants Viral viral infection viral spread were assessed [DOI] 10.3390/ijms23094902 PMC 바로가기 [Article Type] Article
Follicular T cells optimize the germinal center response to SARS-CoV-2 protein vaccination in mice여포 T 세포는 생쥐에서 SARS-CoV-2 단백질 백신 접종에 대한 배 중심 반응을 최적화합니다Article Published on 2022-02-222022-09-12 Journal: Cell Reports [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] addition Affinity maturation aging B cell bimodal Cell cells changes in complex distribution follicular Frequency GC reaction GC response GC responses Germinal center Humoral immunity mice positive presenting promote Reactions regulate Regulatory SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 spike protein Somatic hypermutation T cell T cell help Tfh Tfh cell Tfr these cell These data vaccination Vaccine Vaccines [DOI] 10.1016/j.celrep.2022.110399 PMC 바로가기 [Article Type] Article
Infection or a third dose of mRNA vaccine elicits neutralizing antibody responses against SARS-CoV-2 in kidney transplant recipients감염 또는 세 번째 mRNA 백신 접종은 신장 이식 수혜자의 SARS-CoV-2에 대한 중화 항체 반응을 유발합니다Research Article Published on 2022-02-012022-09-14 Journal: Science Translational Medicine [Category] MERS, SARS, 임상, 진단, [키워드] acting acute respiratory syndrome administration Anti-RBD IgG Cell cell interaction cellular characterized cohorts coronavirus coronavirus disease COVID-19 description dose elicit follicular humoral immune response IgG antibody Immunosuppression immunosuppressive immunosuppressive drugs IMPROVE independent individual infected with SARS-CoV-2 Infection kidney transplant recipient kidney transplant recipients Mortality mRNA vaccine Neutralizing Neutralizing antibody response Neutralizing titer Patient patients patients treated Prevent provided RBD receive recipients regimen rejection response restored SARS-CoV-2 suggested symptomatic T cell response Tfh therapeutic took place Transplant two group two-dose regimen vaccination Vaccine Vaccines [DOI] 10.1126/scitranslmed.abl6141 PMC 바로가기 [Article Type] Research Article
A prospective observational study for justification, safety, and efficacy of a third dose of mRNA vaccine in patients receiving maintenance hemodialysis유지 혈액투석을 받는 환자에서 mRNA 백신 3차 접종의 정당성, 안전성 및 효능에 대한 전향적 관찰 연구Observational Study Published on 2022-02-012022-09-12 Journal: Kidney international [Category] COVID19(2023년), MERS, SARS, 임상, 진단, [키워드] Administered administration Analysis Anti-RBD IgG Anti-spike BNT162b2 CD4 Cohort COVID-19 COVID-19 incidence COVID-19 mRNA vaccine diagnosed died dose doses Efficacy enrolled French generate had more Hemodialysis high responder humoral IgG IMPROVE incidence interferon gamma mRNA vaccine naïve network Neutralizing titer Patient Pfizer positive Predictive prospective observational study PROTECT RBD reached receiving Receptor binding domain reduce registry Responder responders SARS-CoV-2 severity Side effects significantly T-cell T-cell Response Tfh vaccinal vaccination Vaccine variable [DOI] 10.1016/j.kint.2021.10.040 PMC 바로가기 [Article Type] Observational Study
Langerhans cells and cDC1s play redundant roles in mRNA-LNP induced protective anti-influenza and anti-SARS-CoV-2 immune responsesResearch Article Published on 2022-01-242022-10-29 Journal: PLoS Pathogens [Category] COVID-19, [키워드] absence adaptive affected anti-SARS-CoV-2 immune response antibody Cell cytokine Cytokines driven by driving Evidence follicular generate Human humoral immune response humoral immune responses IL-6 immune cell response immune mechanism immune response Inflammatory Inflammatory cytokine Influenza inhibited innate immune cell lack Langerhans cell Lipid nanoparticle mechanism mice mouse model mRNA Neutrophils nucleoside platform PR8 HA PROTECT Protective protective immune response remained required responses robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pandemic shown Side effect significant decrease significantly subset Support susceptibility tested Tfh Tfh cell the antibody response the SARS-CoV-2 triggered vaccination Vaccine vaccine platform [DOI] 10.1371/journal.ppat.1010255 PMC 바로가기 [Article Type] Research Article