Designing a Candidate Multi-Epitope Vaccine against Transmissible Gastroenteritis Virus Based on Immunoinformatic and Molecular DynamicsArticle Published on 2024-08-132024-09-05 Journal: International Journal of Molecular Sciences [Category] update2024, [키워드] epitope molecular docking spike glycoprotein TGEV [DOI] 10.3390/ijms25168828 PMC 바로가기 [Article Type] Article
Historical Evolutionary Dynamics and Phylogeography Analysis of Transmissible Gastroenteritis Virus and Porcine Deltacoronavirus: Findings from 59 Suspected Swine Viral Samples from ChinaArticle Published on 2022-08-292022-11-16 Journal: International Journal of Molecular Sciences [Category] 유전자 메커니즘, [키워드] adaptive addition America Analysis analyzed Asia Bayesian Bayesian inference caused Characteristics China coronavirus COVID-19 epidemic Cross-species transmission distribution Dynamics event Evolution evolutionary dynamics finding genetic diversity Genome sequence data genotypes highlighting Human humans infect likelihood lineages maximum measure membrane fusion Migration Pandemics PDCoV phylogeography Porcine deltacoronavirus Positive selection recent Sample spatiotemporal Spike protein Surveillance Suspected TGEV transmissible gastroenteritis virus Transmission transmission rate transmitted [DOI] 10.3390/ijms23179786 PMC 바로가기
Long-Term Expanding Porcine Airway Organoids Provide Insights into the Pathogenesis and Innate Immunity of Porcine Respiratory Coronavirus InfectionArticle Published on 2022-07-272023-07-09 Journal: Journal of Virology [Category] COVID19(2023년), [키워드] Airway organoids coronavirus interferons PRCoV PRRs TGEV [DOI] 10.1128/jvi.00738-22 PMC 바로가기
Current Status of Genetically Modified Pigs That Are Resistant to Virus InfectionReview Published on 2022-02-172022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] African Antiviral antiviral pigs ASFV Bes classical CRISPR/Cas9 library CSFV current disease effort epidemic diarrhea Factor feasible Fever gastroenteritis generate Government Host host factors host receptor key amino acid knowledge library screening offer PEDV pig problem producing PRRSV PRV reproductive Resistant status sustained syndrome TGEV Tolerance virus virus infection viruses widespread [DOI] 10.3390/v14020417 PMC 바로가기 [Article Type] Review
Modulation of Innate Antiviral Immune Response by Porcine Enteric CoronavirusMicrobiology Published on 2022-02-142022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute diarrhea Antiviral antiviral immune response antiviral immune responses component coronavirus Coronaviruses Defense diarrhea effective eliminating enteric epidemic diarrhea evade Factors gastroenteritis host cell Immune escape immune evasion Infection inhibit Innate Innate immunity innate immunity response Interaction interferon mechanism Neonatal other coronaviruses pathogenic PDCoV PEDV Porcine deltacoronavirus porcine enteric coronaviruses response SADS-CoV target TGEV viral infections virus [DOI] 10.3389/fmicb.2022.845137 PMC 바로가기 [Article Type] Microbiology
Gasdermin D Inhibits Coronavirus Infection by Promoting the Noncanonical Secretion of Beta InterferonResearch Article Published on 2022-02-012023-06-12 Journal: mBio [Category] MERS, [키워드] coronavirus GSDMD IFN-β PDCoV pyroptosis TGEV [DOI] 10.1128/mbio.03600-21 PMC 바로가기 [Article Type] Research Article
All-Trans Retinoic Acid Attenuates Transmissible Gastroenteritis Virus-Induced Inflammation in IPEC-J2 Cells via Suppressing the RLRs/NF‐κB Signaling PathwayImmunology Published on 2022-01-312022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, [키워드] acid Activation all-trans retinoic acid anti-inflammatory activity ATRA attenuate Cell cells damaged downregulated downstream economic loss epithelial epithelial cell gastroenteritis IL-1β IL-6 IL-8 immunomodulatory properties indicated Infection Inflammation Inflammatory Inflammatory cytokine Inflammatory cytokines Inflammatory response inhibiting inhibitor Injury intestinal intestinal inflammation IPEC-J2 cells damage knockdown MAVS MDA5 mechanism molecular mechanism mRNA abundance mRNA expression NF-κB nuclear translocation occludin p65 Pathogenesis Phosphorylation prevented pro-inflammatory cytokines protective effect protein level reduced reduction resulting reversed RIG-I RLRs/NF‐κB pathway signaling molecule signaling pathway significantly Suppressing TGEV TLR3 TLR7 TNF-α Traf6 transmissible gastroenteritis virus Treatment TRIF triggered upregulation ZO-1 [DOI] 10.3389/fimmu.2022.734171 PMC 바로가기 [Article Type] Immunology
Swine Enteric Coronaviruses (PEDV, TGEV, and PDCoV) Induce Divergent Interferon-Stimulated Gene Responses and Antigen Presentation in Porcine Intestinal EnteroidsImmunology Published on 2022-01-202022-11-01 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, [키워드] Antigen presentation antigen-presentation cellular tropism chemokine Clinical signs coronavirus Coronaviruses dataset DEGs demonstrated diarrhea differentially expressed gene discrepancy elevated elicited enteric epidemic diarrhea epithelial exhibited expression gastroenteritis help histocompatibility complex Host IFN IFN response in vivo infect Infection interactions interferons intestinal epithelia intestine ISG majority mechanism MHC-I Neonatal NLR NLRC5 pathogenicity PDCoV PEDV Porcine deltacoronavirus presentation public health receptor replicated response responses TGEV transcriptional profile transcriptomics Treatment type I unique upregulation virus watery while [DOI] 10.3389/fimmu.2021.826882 PMC 바로가기 [Article Type] Immunology
Genome-scale CRISPR screen identifies TMEM41B as a multi-function host factor required for coronavirus replicationResearch Article Published on 2021-12-062022-10-29 Journal: PLoS Pathogens [Category] COVID-19, [키워드] Anti-viral approach Cell contribute contributed coronavirus Coronavirus replication CoV CoV infection CoV replication CoVs CRISPR CRISPR screen Critical disease disease pathogenesis effort Evidence Factor gastroenteritis Health highly pathogenic CoVs Host host gene identification identify Infection inhibit involved kidney performed potential therapeutic target progression Protein provide regulate Replication required reveal RNA virus RNA viruses susceptibility TGEV therapeutic target Tmem41b Vesicle viral infection virus virus replication [DOI] 10.1371/journal.ppat.1010113 PMC 바로가기 [Article Type] Research Article
Evaluation of the Effect of Inactivated Transmissible Gastroenteritis Virus Vaccine with Nano Silicon on the Phenotype and Function of Porcine Dendritic CellsArticle Published on 2021-10-262022-10-28 Journal: Viruses [Category] Coronavirus, MERS, [키워드] Activation characterized coronavirus cytokine cytokine receptor DCs dendritic cell disease Effect ENhance function gastroenteritis help IFN-α IL-12 IL-1β IL-6 immature immune responses inactivated inactivated TGEV vaccine indicated Innate immunity mechanism MSN nano silicon phenotype Research Safe significantly higher silicon TGEV TLR10 TLR3 TLR5 TLR7 TLR9 TNF-α Vaccine virus [DOI] 10.3390/v13112158 PMC 바로가기 [Article Type] Article