In Silico Prediction of New Mutations That Can Improve the Binding Abilities Between 2019-nCoV Coronavirus and Human ACE22019-nCoV 코로나바이러스와 인간 ACE2 간의 결합 능력을 향상시킬 수 있는 새로운 돌연변이의 실리코 예측Article Published on 2022-05-012022-09-11 Journal: IEEE/ACM transactions on computational biology and [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] 2019-nCoV Ability ACE2 Amino acid Analysis binding binding ability binding free energies binding free energy calculate Can change conducted coronavirus coronavirus disease Coronavirus disease 2019 coronavirus spike protein COVID-19 drug drug and vaccine development dynamic ENhance Epidemic Health help Human human ACE2 IMPROVE Interaction international public health mechanism molecular dynamic simulations mutant Mutation mutations nCoV New pathogenic prediction Protein Research selected Simulation Spike protein susceptible The 2019-nCoV Vaccine development virus transmission was obtained [DOI] 10.1109/TCBB.2021.3058265 PMC 바로가기 [Article Type] Article
ACE2 in the Gut: The Center of the 2019-nCoV Infected PathologyMolecular Biosciences Published on 2021-09-212022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] 2019-nCoV ACE2 angiotensin-converting enzyme 2 biological actions blood pressure caused center contagious coronavirus Diagnosis disorder function gastrointestinal tract Gut host cells indication Lungs pharmacological physiological functions Pneumonia Symptom The 2019-nCoV [DOI] 10.3389/fmolb.2021.708336 PMC 바로가기 [Article Type] Molecular Biosciences
A potential hypothesis for 2019-nCoV infection therapy through delivery of recombinant ACE2 by red blood cell-hitchhikingHypothesis Published on 2020-12-072022-10-30 Journal: Journal of Biological Research [Category] COVID-19, [키워드] 2019-nCoV 2019-nCoV infection 2019-nCoV infections ACE2 acting Angiotensin II approach Blood blood circulation bloodstream caused cellular country decrease Diseases drug delivery Epidemic Hypothesis increase Infectious disease investigated liver lung lung failure Lungs Nanoparticles neutralize novel outbreak proportion PROTECT protective role RBC RBC hitchhiking receptor recombinant ACE2 responsible reticuloendothelial system Serum level severe respiratory disease soluble ACE2 spleen Spread The 2019-nCoV Therapeutic approach therapy variety virus [DOI] 10.1186/s40709-020-00129-y PMC 바로가기 [Article Type] Hypothesis
Potential therapeutic target identification in the novel 2019 coronavirus: insight from homology modeling and blind docking studyResearch Published on 2020-10-022022-11-01 Journal: The Egyptian Journal of Medical Human Genetics [Category] COVID-19, [키워드] 2019-nCoV 3CLpro 3D structure activities administration Amino acid binding site blind carried co-crystallized coding sequence Comparative coronavirus coronavirus epidemic Coronaviruses docked docking study elicited Genome HIV protease inhibitor homology Human inhibitors International Ligand mapped Novel coronavirus outbreak polyprotein polyproteins positive-sense single-stranded RNA Potential protease Protein proteinase Proteolytic processing public health reduced Replication Result selected sequence shown target protein The 2019-nCoV therapeutic agent therapeutic target translated Treatment viral infection viral replication virus [DOI] 10.1186/s43042-020-00081-5 PMC 바로가기 [Article Type] Research
Recognition of Natural Products as Potential Inhibitors of COVID-19 Main Protease (Mpro): In-Silico EvidencesOriginal Article Published on 2020-06-172022-10-30 Journal: Natural Products and Bioprospecting [Category] COVID-19, [키워드] 2019-nCoV anti-viral activity Antiviral antiviral activity Candidates caused Compound coronavirus disease COVID-19 Covid-19 main protease docking docking study druggability evidenced exhibiting globe glycyrrhizin Herbal remedies hesperetin Host in silico molecular docking natural nCOV-2019 outcome overcome plant Potential product protease receptor Recognition reported SARS-CoV SARS-CoV-2 scientist selected The 2019-nCoV Treatment [DOI] 10.1007/s13659-020-00253-1 PMC 바로가기 [Article Type] Original Article
Psychological impact of 2019 novel coronavirus (2019-nCoV) outbreak in health workers in ChinaOriginal Paper Published on 2020-05-202022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus 2019-nCoV average China Chinese collected COVID-19 Critical evaluate Factors female Gender group health worker health workers Impact individual Infection IQR male Mild Multiple occurred outbreak participated Pneumonia Probability Psychological public health questionnaire regression analysis scale Seafood South statistical difference The 2019-nCoV the epidemic the median was used were used Wuhan [DOI] 10.1017/S0950268820001090 PMC 바로가기 [Article Type] Original Paper
Transmission routes of 2019-nCoV and controls in dental practiceReview Article Published on 2020-03-032022-10-29 Journal: International Journal of Oral Science [Category] COVID-19, MERS, SARS, [키워드] 2019-nCoV 2019-nCoV infection ACE2 BatCoV RaTG13 Blood body fluids caused China clinics Contact Control cough dental Face-to-face communication fetal pneumonia handling hospitals Host host receptor human Angiotensin-converting enzyme identity infection control measure mucous membranes nasal participant Policy and public health in microbiology preventing the transmission professional risk Risk factors Saliva SARS-CoV sneeze spread to The 2019-nCoV Transmission transmission route transmitted whole-genome Wuhan β-coronavirus [DOI] 10.1038/s41368-020-0075-9 PMC 바로가기 [Article Type] Review Article
Estimating the Unreported Number of Novel Coronavirus (2019-nCoV) Cases in China in the First Half of January 2020: A Data-Driven Modelling Analysis of the Early OutbreakArticle Published on 2020-02-012022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 2019-nCoV approximation average basic reproduction number caused China coronavirus CoV CoVs growth Infection initial interval likelihood MERS Middle East modelling novel Novel coronavirus number occurred outbreak Reproduction number respiratory Respiratory illness spread to The 2019-nCoV the epidemic Underreporting Unreported was determined Wuhan, China [DOI] 10.3390/jcm9020388 PMC 바로가기 [Article Type] Article