Urtica dioica Agglutinin: A plant protein candidate for inhibition of SARS-COV-2 receptor-binding domain for control of Covid19 InfectionUrtica dioica Agglutinin: Covid19 감염 통제를 위한 SARS-COV-2 수용체 결합 도메인 억제를 위한 식물성 단백질 후보Article Published on 2022-07-282022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] ACE2 addition angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 Antiviral effect average bind binding binding affinity binding energy binding free energy binding site calculated Cell complex convalescent serum coronavirus docked docking docking result docking results domain Donor donors dynamic effective effective drug effective drugs ELISA ELISA assay enzyme exhibited free energy Gromacs host cell human cells IgG Infection inhibit inhibitory activity Interaction limitation MD simulation mechanism Medicine Medicines MTT Mutation peptide Prevent Previous studies Protein RBD RBD binding RBD complex RBD protein Receptor-binding domain Result S-protein Safe SARS-CoV SARS-CoV-2 Simulation spike Spike protein spike protein of SARS-CoV-2 stability the cell the RBD Toxicity Urtica Vaccine virus was performed was used [DOI] 10.1371/journal.pone.0268156 PMC 바로가기 [Article Type] Article
Viral load is associated with mitochondrial dysfunction and altered monocyte phenotype in acute severe SARS-CoV-2 infection바이러스 부하는 급성 중증 SARS-CoV-2 감염에서 미토콘드리아 기능 장애 및 변경된 단핵구 표현형과 관련이 있습니다Article Published on 2022-07-012022-09-11 Journal: International immunopharmacology [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, [키워드] CD14 CD16 CD39 Cell cell surface classical monocyte classical monocytes Clinical outcome COVID-19 COVID-19 patient COVID-19 patients COVID-19 severity determined by evaluated exhibited expression Frequency GM-CSF healthy control healthy controls high viral load HLA-DR Hospital admission IFN-α Immune checkpoints induce Infection initial innate immune innate immune response less membrane Mitochondria mitochondrial mitochondrial dysfunction Mitochondrial function monocyte Monocyte activation Monocytes oxygen pathological mechanism patients PD-1 phenotype reactive oxygen species reactive oxygen specy SARS-CoV-2 SARS-CoV-2 viral load severe COVID-19 severe COVID-19 patient severe COVID-19 patients severe SARS-CoV-2 severity the cell the median These data Viral viral burden Viral load with COVID-19 [DOI] 10.1016/j.intimp.2022.108697 PMC 바로가기 [Article Type] Article
ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike ProteinORFeome 파지 디스플레이, SARS-CoV-2 스파이크 단백질의 S2 하위 도메인에 대한 주요 면역원성 에피토프 공개Article Published on 2022-06-172022-09-11 Journal: Viruses [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] Amino acid amino acid sequence anti-SARS-CoV-2 antibodies antibodies antibody Antibody Response Antibody responses applied approved binding binding site blocking cell entry cleave COVID-19 COVID-19 pandemic COVID-19 patients Diseases display Efficacy epitope epitope mapping Epitopes fusion peptide genomic genomic library Host host cell identify immunogenic library Major mechanism monoclonal antibody mutate Mutation neutralization neutralize NGS Open reading frame open reading frames ORFeome ORFs Particle peptide phage phage display RBD RBD region Receptor binding domain representing SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 variant SARS-CoV-2 variants sequence Serine serine protease serine protease TMPRSS2 spike the cell the RBD the SARS-CoV-2 genome therapeutic therapy TMPRSS2 Vaccine virus variants [DOI] 10.3390/v14061326 PMC 바로가기 [Article Type] Article
Anti-nucleocapsid antibodies enhance the production of IL-6 induced by SARS-CoV-2 N protein항-뉴클레오캡시드 항체는 SARS-CoV-2 N 단백질에 의해 유도된 IL-6의 생산을 향상시킵니다Article Published on 2022-05-162022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 바이오마커, 진단, 치료법, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition antibody cause of death cell lysate coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient cultured macrophage cultured macrophages cytokine cytokine production Cytokine storm death disease ENhance IL-6 induce infected cells interleukin lysate macrophages mechanism myeloid cells N protein Patient patients Plasmid promote respiratory respiratory distress SARS-CoV-2 SARS-CoV-2 N protein SARS-CoV-2-infected cell SARS-CoV-2-infected cells Screening secreted sera severe acute respiratory syndrome Coronavirus syndrome the cell the cells the cytokine storm the disease [DOI] 10.1038/s41598-022-12252-y PMC 바로가기 [Article Type] Article
Enoxaparin augments alpha-1-antitrypsin inhibition of TMPRSS2, a promising drug combination against COVID-19Enoxaparin은 COVID-19에 대한 유망한 약물 조합인 TMPRSS2의 알파-1-항트립신 억제를 증가시킵니다.Article Published on 2022-03-252022-09-11 Journal: Scientific Reports [Category] SARS, 변종, 진단, 치료법, [키워드] affected alpha-1-antitrypsin anti-inflammatory activity antitrypsin Cell cells cleave complex consequence Coronavirus infection COVID-19 crystal structure drug combination ENhance enoxaparin epithelial cell epithelial cells hAEC HCoV HCoV-229E HEK293T cell HEK293T cells heparin human coronavirus human coronavirus 229E immunostaining Infection Inflammatory less molecular nafamostat Neutralizing nucleocapsid protein overexpressing Plaque assay primary human airway Primary human airway epithelial cells quantified reactive required SARS-CoV-2 SARS-CoV-2 mutations Serine serine protease severe COVID-19 Spike protein the cell the spike protein therapy TMPRSS2 TMPRSS2 inhibitor Treatment Viral viral entry virus was determined [DOI] 10.1038/s41598-022-09133-9 PMC 바로가기 [Article Type] Article
Cryo-EM structure of a SARS-CoV-2 omicron spike protein ectodomainSARS-CoV-2 오미크론 스파이크 단백질 엑토도메인의 Cryo-EM 구조Article Published on 2022-03-032022-09-11 Journal: Nature Communications [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] cell entry conformations Critical cryo-EM structure ectodomain globe immune immune evasion immune surveillance mechanism mixture Mutation Neutralizing antibodies neutralizing antibody Omicron variant open RBD RBD region Receptor binding Receptor-binding domain SARS-CoV-2 Spike protein standing up Surveillance the cell the receptor-binding domain the spike protein viral strain [DOI] 10.1038/s41467-022-28882-9 PMC 바로가기 [Article Type] Article
Binding mechanism and structural insights into the identified protein target of COVID-19 and importin-α with in-vitro effective drug ivermectinin-vitro 효과적인 약물 Ivermectin과 Covid-19 및 importin-α의 확인 된 단백질 표적에 대한 결합 메커니즘 및 구조적 통찰력Article Published on 2022-03-012022-08-31 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 치료제, [키워드] (RdRp Antiviral antiviral drug approved cell line complex COVID-19 drug complexes drug design effective FDA followed by free energy Helicase identification Importin In-vitro Interaction involved Ivermectin lead mechanism mechanism of action MM/PBSA molecular molecular dynamics molecular target Protein protein-drug complex protein-drug complexes RdRP reduce reported reveal RNA RNA dependent RNA polymerase RNA polymerase SARS-CoV-2 selectivity stability target the cell the strongest triggered while [DOI] 10.1080/07391102.2020.1839564 PMC 바로가기 [Article Type] Article
Expressions and significances of CTSL, the target of COVID-19 on GBMCTSL의 표현 및 중요성, GBM에서 Covid-19의 목표Article Published on 2022-03-012022-08-31 Journal: Journal of cancer research and clinical oncology [Category] MERS, SARS, 바이오마커, [키워드] analyzed Apoptosis association B cell biological activity Brain tissues cathepsin cathepsin L CD8 Cell Coronavirus infection correlated COVID-19 CTSL database expression level Glioblastoma glioblastoma multiforme growth Immune cell infiltration immune infiltration independent Infection inhibitor investigated mitochondrial New coronavirus overall survival Patient patients Prognosis Prognostic factor Proteases purity reduced risk significantly significantly lower subsequent survival survival rate T cell the cell therapeutic target tissue virus was tested [DOI] 10.1007/s00432-021-03843-9 PMC 바로가기 [Article Type] Article
Absence of YhdP, TamB, and YdbH leads to defects in glycerophospholipid transport and cell morphology in Gram-negative bacteriaYHDP, TAMB 및 YDBH의 부재는 그람 음성 박테리아에서 글리세로 포스 포스 폴리티드 수송 및 세포 형태의 결함으로 이어진다Research Article Published on 2022-02-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] absence accumulate adjust anterograde antibiotic Antibiotic resistance asymmetric Bacterial balance biosynthetic biosynthetic pathways Cell cell envelope cell lysis changes in characterized component contribute Critical Defense effective foundation gram Gram-negative bacteria homeostasis homologues inner leaflet leads lipopolysaccharide LPS maintain maintaining membrane membrane vesicles morphology mutant offer outer membrane overexpression pathway phenotype Phenotypes Protein provide reducing rescued restored sensitivity shedding the cell Therapies Threats translocated Transport understanding vesicles viability [DOI] 10.1371/journal.pgen.1010096 PMC 바로가기 [Article Type] Research Article
Activation of Complement Components on Circulating Blood Monocytes From COVID-19 PatientsCOVID-19 환자의 순환 혈액 단핵구에 대한 보체 성분 활성화Immunology Published on 2022-02-172022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 바이오마커, [키워드] Activation acute infection amyloid A Asymptomatic Biomarker blood monocyte C1q caused CD55 Cell cell surface cells cellular characterized circulating classical Coagulopathy complement Complement activation Complement inhibitor component coronavirus coronavirus disease COVID-19 COVID-19 disease COVID-19 pathogenesis COVID-19 patient COVID-19 patients CRP death downstream elevated HCs healthy control healthy controls highlight hyperinflammation implicated IMPROVE increase Increased Increases Inflammation Inflammatory marker inhibitor Interaction membrane membrane-bound monocyte Monocytes multi-organ failure myeloid cell myeloid cells plasma remained SARS-CoV-2 virus serum amyloid Severe infection surface expression the cell the SARS-CoV-2 virus upregulated upregulation with COVID-19 [DOI] 10.3389/fimmu.2022.815833 PMC 바로가기 [Article Type] Immunology