Ultrarapid and ultrasensitive detection of SARS-CoV-2 antibodies in COVID-19 patients via a 3D-printed nanomaterial-based biosensing platformArticle Published on 2022-12-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] 3D biosensor 3D printing Additive manufacturing antibody Antibody detection coated with Concentration COVID-19 COVID-19 antibodies COVID-19 patient COVID-19 patients Critical detected antibody disease domain Efficacy Epidemics Epidemiology evaluate Gold nanoparticle Graphene oxide human plasma samples immune response Immunity Infection Interaction manuscript nucleocapsid Outbreaks Patient patients without COVID-19 platform Quantitative Rapid rapid antibody detection. rapid antibody test RBD reported SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 antigens serological Spike protein the antibodies the N protein vaccination Vaccine Viral protein were used [DOI] 10.1002/jmv.28075 PMC 바로가기
Discovery and structural characterization of chicoric acid as a SARS-CoV-2 nucleocapsid protein ligand and RNA binding disruptorArticle Published on 2022-11-022022-11-15 Journal: Scientific Reports [Category] SARS, 치료제, [키워드] Antiviral antivirals binding C-terminal domain cell cultures compounds coronavirus Critical CTD disrupt Genome identify information isothermal titration calorimetry Ligand ligands N protein N-protein NMR nucleocapsid Protein reduced representing RNA SARS-CoV-2 nucleocapsid SARS-CoV-2 replication small molecule the N protein the SARS-CoV-2 the SARS-CoV-2 genome Transcription [DOI] 10.1038/s41598-022-22576-4 PMC 바로가기
A Rapid SARS-CoV-2 Nucleocapsid Protein Profiling Assay with High Sensitivity Comparable to Nucleic Acid DetectionArticle Published on 2022-10-252022-11-15 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] acid Antigen binding caused Concentration COVID-19 COVID-19 diagnosis detection DNA effective ELISA kits Epidemic Epidemics information limit of detection magnitude N protein nucleic acid nucleocapsid protein PCR Profiling Protein Rapid Region resulting Saliva SARS-CoV-2 sensitivity target protein The fluorescence intensity the N protein translation [DOI] 10.1021/acs.analchem.2c02670 PMC 바로가기
Protection from COVID-19 with a VSV-based vaccine expressing the spike and nucleocapsid proteinsArticle Published on 2022-10-242022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] acute respiratory syndrome addition Administered caused conserved coronavirus COVID-19 COVID-19 pandemic disease Efficacy effort expressing Hamster model highlighting intranasal intranasal vaccination memory morbidity and mortality nucleocapsid nucleocapsid protein pandemic PROTECT protection Protective Protein reduce reduced resulting SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 single dose the N protein the SARS-CoV-2 vaccination Vaccine variants of concern vesicular stomatitis virus Viral antigen viral shedding VoC with COVID-19 [DOI] 10.3389/fimmu.2022.1025500 PMC 바로가기
Comparison of the kinetics and magnitude of antibody responses to different SARS-CoV-2 proteins in Sinopharm/BBIBP-CorV vaccinees following the BNT162b2 booster or natural infectionArticle Published on 2022-10-132022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, [키워드] ACE2 anti-RBD antibodies antibody Antibody Response BNT162b2 booster Cohort dose Frequency highest IgG antibody immune response implication individual infected individual Infection investigated lowest magnitude natural infection persistence post vaccination Protein receive remained robust S1 and S2 SARS-CoV-2 protein second dose significantly higher Sinopharm subsequent the N protein the RBD the SARS-CoV-2 virus total antibody uninfected vaccinee vaccinees were infected [DOI] 10.1371/journal.pone.0274845 PMC 바로가기
Impact of antigen test target failure and testing strategies on the transmission of SARS-CoV-2 variantsArticle Published on 2022-10-052022-11-15 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] absence amino-acid Antigen compartmental model country COVID-19 diagnostic epidemiological data genomic highlight identify Impact increasingly Italian Italy limitation molecular Molecular tests N antigen Population SARS-CoV-2 variant Sequencing Spread Substitution Surveillance the N protein transmission of SARS-CoV-2 variant variants Veneto widespread [DOI] 10.1038/s41467-022-33460-0 PMC 바로가기
An electrochemical aptasensor with N protein binding aptamer-complementary oligonucleotide as probe for ultra-sensitive detection of COVID-19N 단백질 결합 앱타머-상보성 올리고뉴클레오티드를 COVID-19의 초고감도 검출을 위한 프로브로 사용하는 전기화학적 앱타센서Article Published on 2022-10-012022-09-11 Journal: Biosensors & bioelectronics [Category] 치료기술, 치료제, [키워드] affected applied aptamer binding blood sample Blood samples changes in complementary Complementary DNA Concentration conformational COVID-19 COVID-19 epidemic COVID-19 in patients DNA double-stranded Early detection effective Electrochemical aptasensor gold hybridization Incubation linear relationship log logarithm N protein N protein detection probe R 2 Rapid Rapid COVID-19 diagnosis Regenerable aptamer sensor. reported sensor solution target the N protein throat swab throat swabs vaccination volunteers was measured [DOI] 10.1016/j.bios.2022.114436 PMC 바로가기 [Article Type] Article
Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivationArticle Published on 2022-09-142022-11-16 Journal: Signal Transduction and Targeted Therapy [Category] SARS, 유전자 메커니즘, [키워드] activated Activation acute respiratory syndrome Adenovirus aggravate Aggravated alleviate complement Complement pathway contribute coronavirus Coronaviruses expressing highly pathogenic human coronaviruses Hyperactivation in vitro in vivo Inflammation inflammatory lung injury Inflammatory response Interaction lectin pathway Lung injury MASP-2 mechanism MERS-CoV mice N protein Pathogenesis pathogenic coronavirus Pneumonia respiratory syndrome coronavirus resulting SARS-CoV SARS-CoV-2 SARS-CoV-2-infected patients serine protease significantly suggested the N protein Therapeutic approach These data [DOI] 10.1038/s41392-022-01133-5 PMC 바로가기
HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2Article Published on 2022-09-062022-11-16 Journal: Communications Biology [Category] SARS, 치료기술, [키워드] age antibodies CD4 CD8 contributing to controls convalescent disease severity eight Factor functional heterogeneity HLA HLA alleles Humoral response Icelanders induce infection with SARS-CoV-2 investigated Protein reactive SARS-CoV-2 SARS-COV-2 infection Symptom T-cell immunity T-cell Response T-cell responses the N protein uninfected [DOI] 10.1038/s42003-022-03893-w PMC 바로가기
Utility of in silico-identified-peptides in spike-S1 domain and nucleocapsid of SARS-CoV-2 for antibody detection in COVID-19 patients and antibody productionArticle Published on 2022-09-052022-11-15 Journal: Scientific Reports [Category] SARS, 변종, 진단, 치료기술, [키워드] 2D structure 3D structure analyzed antibody Antibody detection antibody production Antibody Response Antigen antigenic peptides changes in COVID-19 patient COVID-19 patients domain eight Evidence homology immunogenic in silico analysis limitation N protein New nucleocapsid peptide performed Proteins provide RBD Result S1 domain SARS-CoV-2 SARS-CoV-2 variant selected sequence serum serum sample Seven Standardization structural proteins the N protein the spike protein trimer virus viruses were used [DOI] 10.1038/s41598-022-18517-w PMC 바로가기