Strategies to tackle SARS-CoV-2 Mu, a newly classified variant of interest likely to resist currently available COVID-19 vaccines현재 사용 가능한 COVID-19 백신에 저항할 가능성이 있는 새로 분류된 관심 변종인 SARS-CoV-2 Mu에 대처하기 위한 전략Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 administration adopted approach B.1 lineage B.1.621 BNT161b2 booster dose Characteristics coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 vaccine COVID-19 vaccine development Evidence exacerbated Genetic genomic Genomic surveillance global mass vaccination Health implementation infections Intervention Lineage mass vaccination Mu variant mutations Neutralizing non-pharmaceutical interventions (NPIs) NPIs potential risk public health measure public health measures Recombination reported required respiratory restrict SARS-CoV-2 SARS-CoV-2 B.1.621 SARS-CoV-2 virus sera shown Strains Strategy sub-lineage B.1.621.1 Surveillance survivor the SARS-CoV-2 virus therapeutic threat vaccination Vaccine Vaccine breakthrough Vaccine development variant variants [DOI] 10.1080/21645515.2022.2027197 PMC 바로가기 [Article Type] Article
A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant Simulations Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
A novel statistical method predicts mutability of the genomic segments of the SARS-CoV-2 virusResearch Article Published on 2022-12-132022-10-29 Journal: Qrb Discovery [Category] COVID-19, [키워드] affected antiviral drugs approach candidate coding regions codon conserved correlated correlation determine develop disease distribution effective epitope Frequency genomic identify immunogenic peptide large-scale analysis mutability offer overcome pandemic pathogenesis of SARS-CoV-2 predict predicted Protein SARS-CoV-2 SARS-CoV-2 virus SARS-CoV2 scientist sequence Seven spike glycoprotein statistical statistical analysis target the SARS-CoV-2 virus treatments for COVID-19 Vaccine viral genome viral mutation whole genome whole genome sequence Word Ranking [DOI] 10.1017/qrd.2021.13 PMC 바로가기 [Article Type] Research Article
ACE2 decoy receptor generated by high-throughput saturation mutagenesis efficiently neutralizes SARS-CoV-2 and its prevalent variants고처리량 포화 돌연변이 유발에 의해 생성된 ACE2 미끼 수용체는 SARS-CoV-2 및 그 유행하는 변이체를 효율적으로 중화합니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, [키워드] ACE2 ACE2 binding ACE2-RBD binding approach binding binding affinity C-terminal cellular receptor changes in convalescent sera Critical critical point D614G decoy receptor domain Effect fused global pandemic glycosylation site High-throughput screening increase in Microarray monoclonal antibodies Mutagenesis mutations neutralization neutralize neutralized Omicron variant Point mutation prevalent protease Protein protein engineering Pseudotyped virus RBD RBD binding RBD-ACE2 receptor Receptor binding domain rescued SARS-CoV-2 SARS-CoV-2 virus significantly single-cell soluble ACE2 Spike protein the SARS-CoV-2 the SARS-CoV-2 virus therapeutic potential Treatment Vaccine variant variants viral entry viral spike protein wild-type [DOI] 10.1080/22221751.2022.2079426 PMC 바로가기 [Article Type] Article
Sensitive detection of SARS-CoV-2 molecular markers in urban community sewersheds using automated viral RNA purification and digital droplet PCRArticle Published on 2022-11-152022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 바이오마커, 치료기술, [키워드] affecting approach automated Care Community correlation COVID-19 COVID-19 case detection of marker Detroit disadvantage Effectiveness Epidemiology faster Final handling Health identify inhibitor Local marker molecular number of sample outbreak PCR PerkinElmer Prevent Promega public health authority purification required RNA RNA purification SARS-CoV-2 sensitive sensitivity Standard state the SARS-CoV-2 virus Thermofisher time-consuming Viral RNA Volume wastewater [DOI] 10.1016/j.scitotenv.2022.157547 PMC 바로가기
Hydrothermal deconstruction of single-use personal protective equipment during the COVID-19 pandemicArticle Published on 2022-11-012022-11-15 Journal: Waste management (New York, N.Y.) [Category] SARS, 치료기술, [키워드] acetic adopted ammonia carbon dioxide Concentration Contamination COVID-19 COVID-19 pandemic Fatty acid Hydrothermal deconstruction increase in initial Isolation lowest Masks oxygen Personal protective equipment PPE produced Protective Regulation selected surgical temperature the SARS-CoV-2 virus Transmission TSS was reduced waste waste management Wet Wet oxidation. [DOI] 10.1016/j.wasman.2022.09.006 PMC 바로가기
A subunit vaccine candidate based on the Spike protein of SARS-CoV-2 prevents infectious virus shedding in catsSARS-CoV-2의 스파이크 단백질을 기반으로 하는 서브유닛 백신 후보는 고양이의 감염성 바이러스 발산을 방지합니다Article Published on 2022-11-012022-09-11 Journal: Research in veterinary science [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] affected cats demonstrated described effective human infection Infection Infectious virus Neutralizing antibody response occurred Oropharyngeal Population Prevent preventive measure preventive measures produced Protein rectal swab SARS-CoV-2 SARS-CoV-2 virus spike Spike protein submitted subunit Subunit vaccine susceptible the disease the SARS-CoV-2 virus the Spike Transmission Trial triggered vaccination Vaccine vaccine candidate Viral viral infection virus [DOI] 10.1016/j.rvsc.2022.05.003 PMC 바로가기 [Article Type] Article
An external quality assessment for the molecular testing of the SARS-CoV-2 virus genome in Zhejiang Province, ChinaArticle Published on 2022-11-012022-11-15 Journal: Diagnostic microbiology and infectious disease [Category] COVID19(2023년), SARS, 진단, [키워드] Accuracy Asymptomatic CDC China Combination Concentration concentrations Concordance COVID-19 COVID-19 pandemic Culture diagnostics external quality assessment false-negative False-positive Genome infected individual Laboratory medium molecular molecular diagnostics negative sample nucleic acid extraction organized participated PCR Population positive sample provide public health rapid expansion reagents SARS-CoV-2 SARS-CoV-2 test SARS-CoV-2 tests serial dilution the SARS-CoV-2 virus viral titer Zhejiang [DOI] 10.1016/j.diagmicrobio.2022.115766 PMC 바로가기
Systematic comparison of ranking aggregation methods for gene lists in experimental resultsArticle Published on 2022-10-312022-11-16 Journal: Bioinformatics [Category] COVID19(2023년), meta-analysis, SARS, [키워드] addition aggregation Algorithm Apoptosis automated Bacteria biological process Cancer Cell Characteristics code Consensus database dataset datasets disease downloaded Evaluating Features genomic data heterogeneity implementation implicated Inclusion information lack list of gene lung cancer Macrophage Meta-analysis noise level question reliability required resulting specific type Support the SARS-CoV-2 virus Variation was performed were used [DOI] 10.1093/bioinformatics/btac621 PMC 바로가기
Diffusion-Induced Ingress of Angiotensin-Converting Enzyme 2 into the Charge Conducting Path of a Pentacene Channel for Efficient Detection of SARS-CoV-2 in Saliva SamplesArticle Published on 2022-10-282022-11-15 Journal: ACS Sensors [Category] COVID19(2023년), SARS, 치료기술, [키워드] accelerate ACE2 angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) biosensor can be used channel charge Conducting correlation COVID-19 detection diagnostic test disease efficient false-negative field-effect transistor. gold standard growth handling highest integration Laboratory Large-scale testing less medium molecular Organic field-effect transistor path pathogen platform POC point-of-care Rapid receptor remote monitoring reported Saliva Sample SARS-CoV-2 sensitivity specimens Spread statistical analysis the disease the epidemic the SARS-CoV-2 virus the spike protein transfer Viral RNA viral titer virus [DOI] 10.1021/acssensors.2c01287 PMC 바로가기