Increased global integration in the brain after psilocybin therapy for depression Research Published on 2022-04-112022-10-05 Journal: Nature Medicine [Category] 바이오마커, 임상, [키워드] Administered Analysis baseline Brain changes changes in clinical trial correlated decrease Depression depressive disorder dose double-blind Effect flexible functional increase in Increased increases in indicated magnetic resonance imaging mechanism network Open-label Patient Placebo primary outcome measure psilocybin Randomized controlled trial robust sustained therapeutic action therapy Treatment Trial trials was recorded [DOI] 10.1038/s41591-022-01744-z [Article Type] Research
Assessment of Antioxidant, Immunomodulatory Activity of Oxidised Epigallocatechin-3-Gallate (Green Tea Polyphenol) and Its Action on the Main Protease of SARS-CoV-2—An In Vitro and In Silico ApproachArticle Published on 2022-01-312022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] Action activity Analysis antioxidant antioxidation applied assessment AutoDock cell line COVID-19 docking docking score effective Efficacy EGCG epigallocatechin evaluate green highest Human human clinical trials IL-1 IL-1β IL-6 immunomodulatory Improved in silico in silico Approach in vitro in vivo Inflammatory Inflammatory marker inhibitory action lipid peroxidation M pro marker mechanism of action molecular docking molecular docking analysis oxidised EGCG polyphenol pro-inflammatory protease residue SARS-CoV-2 shown significant decrease tea therapeutic action therapeutic effects these compound TNF- α TNF-α total antioxidant capacity undergo was performed were used [DOI] 10.3390/antiox11020294 PMC 바로가기 [Article Type] Article
Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and PharmacokineticsReview Published on 2021-10-142022-10-29 Journal: International Journal of Molecular Sciences [Category] Coronavirus, MERS, SARS, [키워드] Action administration antimicrobial antiseptic actions base caused Chinese Chinese herbal medicine Chinese herbal medicines Clinical efficacy complex COVID-19 current drug dysregulated Herbal host response incidence life-threatening management material basis mechanism Medicine Medicines modulating Mortality organ dysfunction Pathogenesis pathophysiology pharmacokinetics pharmacological phytochemistry Progress Qingwen Baidu decoction Research Sepsis Shengfu injection Shengmai supportive therapies therapeutic action Treatment treatment approach Xuanbai Chengqi decoction xuebijing injection [DOI] 10.3390/ijms222011078 PMC 바로가기 [Article Type] Review
The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic EfficacyReview Published on 2021-07-202022-10-28 Journal: The Cochrane database of systematic reviews [Category] COVID-19, [키워드] acute respiratory syndrome addition adjuvant therapy Anti-inflammatory antioxidant backbone circadian rhythms clinical study clinical trials Contact coronavirus coronavirus disease COVID-19 Critical demonstrated Efficacy exacerbated homeostasis Host hosts immune response Infection infective Inflammation melatonin microbe Mitochondria oxidative pandemic Protective reactive oxygen respiratory diseases response Safety SARS-CoV-2 supported therapeutic action virus virus variant [DOI] 10.3390/antiox10071152 PMC 바로가기 [Article Type] Review
Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across speciesResearch article Published on 2020-12-012022-10-05 Journal: Neurobiology of Learning and Memory [Category] 비임상, [키워드] Abstract addition ADHD Alter anti-inflammatory action Attention benefit Brain cognitive cortical deficit dendritic Effect Evidence executive expand explain function functions Guanfacine inhibit Injury Intuniv mechanism of action memory Mental disorder Mental Disorders microglia modulation neuronal NMDAR Norepinephrine off-label plasticity Potassium reducing Research Schizophrenia selective Signaling Stress stress-related disorder synaptic therapeutic action translation translational variety Working memory α2A-adrenoceptor [DOI] 10.1016/j.nlm.2020.107327 [Article Type] Research article
The role of pharmaceutical nanotechnology in the time of COVID-19 pandemic코로나19 팬데믹 시대에 제약 나노기술의 역할Review Published on 2020-11-202022-09-10 Journal: Future Microbiology [Category] SARS, 비임상, 임상, 치료제, [키워드] Antiviral antiviral activity approach approved breath Clinical use COVID-19 COVID-19 pandemic COVID-19 treatment COVID-19 treatments demonstrated drug drug toxicity drugs effective therapy Efficacy exhibiting IMPROVE in vitro nanostructured delivery systems Nanotechnology Potential treatment potential treatments tested therapeutic action Toxicity Treatment [DOI] 10.2217/fmb-2020-0118 PMC 바로가기 [Article Type] Review
Drug repurposing of nitazoxanide: can it be an effective therapy for COVID-19?Review Published on 2020-07-282022-10-30 Journal: Journal of Genetic Engineering & Biotechnology [Category] COVID-19, [키워드] Abstract aggravate airway antiparasitic drug antiviral activity antiviral drug Broad spectrum antiviral bronchodilation clinical trial clinical trials Concentration Coronaviruses COVID-19 COVID-19 patients cytokine Cytokine storm Cytokines disease Drug repurposing effective effective therapy Efficacy effort exhibited HBV HCV Hepatitis B virus hepatitis C virus highlight in vitro Influenza outbreak over pandemic coronavirus potential benefit reported Repurposed nitazoxanide Research SARS-CoV-2 suppresse Symptoms therapeutic action viral infection virus [DOI] 10.1186/s43141-020-00055-5 PMC 바로가기 [Article Type] Review