Vitamin D and interferon-γ co-operate to increase the ACE-2 receptor expression in primary cultures of human thyroid cellsArticle Published on 2022-11-012022-11-15 Journal: Journal of Endocrinological Investigation [Category] COVID19(2023년), SARS, 진단, [키워드] ACE-2 ACE-2 receptor angiotensin Cell Cell culture cell membrane cells chain Combination combination treatment Course COVID-19 defend demonstrated experiment expressed expression Host IFN-γ immune defense immunocytochemistry in vitro data interferon-γ material membrane mRNA mRNA level observation primary culture Protein protein level reaction receptor RT-PCR SARS-CoV-2 shown supported Therapeutic benefit Thyrocytes Thyroid tissue treated Treatment up-regulate up-regulated up-regulating Vitamin D were measured would increase [DOI] 10.1007/s40618-022-01857-9 PMC 바로가기
The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia FormationArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome appear assays catalytic caused Cell cell-cell fusion cell-cell fusion assay cells cellular cellular component cellular membrane contribute coronavirus coronavirus SARS-CoV-2 Coronaviruses COVID-19 COVID-19 pandemic dead defend Defense Efficiency ENhance entry of SARS-CoV-2 examined Formation genetic knockout global public health host cell membranes IFITM IFITMs in viral include Infection inhibiting inhibitory activity innate immune innate immune response Integral interact Interaction interfere intrinsic knockdown lentivirus maturation mechanism membrane membrane protein MHV mouse hepatitis virus nuclear overexpression pandemic Plaque assay precursor prelamin A Prevent protease Proteases PROTECT Protective protective role Protein proteolytic proteolytic activity reduce required restriction factor restriction factor. SARS-CoV-2 SARS-CoV-2 pseudovirus infection shown spike Therapeutic benefit transmembrane protein viral infection viral infections virus virus entry viruses wild-type ZMPSTE24 [DOI] 10.1128/mbio.02543-22 PMC 바로가기
The potential role of ischaemia-reperfusion injury in chronic, relapsing diseases such as rheumatoid arthritis, Long COVID, and ME/CFS: evidence, mechanisms, and therapeutic implicationsArticle Published on 2022-08-312022-11-15 Journal: Biochemical Journal [Category] 진단, [키워드] activities amyloid microclots antioxidants biochemical burst Capillaries cell activation conditions COVID disease element Evidence explain hyperinflammation hypoxia implication Inflammatory diseases initiated Injury involved ischaemia–reperfusion injury. Long Long COVID malaise marker mechanism mechanisms metabolite Occurrence oxidative stress pathology produced reactive oxygen specy relapsing reperfusion rheumatoid arthritis Safe therapeutic Therapeutic benefit variety [DOI] 10.1042/BCJ20220154 PMC 바로가기
Convalescent plasma donors show enhanced cross-reactive neutralizing antibody response to antigenic variants of SARS-CoV-2 following immunization회복기 혈장 기증자는 예방 접종 후 SARS-CoV-2의 항원 변이체에 대한 향상된 교차 반응성 중화 항체 반응을 보여줍니다Article Published on 2022-07-012022-09-11 Journal: Transfusion [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Alpha anti-SARS-CoV-2 anti-spike antibody antibody Antibody neutralization antigenic antigenic variant antigenic variants antigenic variation automated Beta circulating convalescent convalescent plasma COVID-19 cross-reactive Delta determined by Donor dose Effect Elecsy focus geometric mean geometric mean titer GMT GMTs immunization infected with SARS-CoV-2 Live virus microneutralization NAb NAb titers NAbs neutralization neutralization potency neutralization test neutralize Neutralizing antibodies neutralizing antibody Neutralizing antibody response omicron Pfizer plasma Predictive prototype Quantitative reactivity reduction ROC analysis Roche Sample SARS-CoV-2 SARS-CoV-2 strain specificity strain Strains Therapeutic benefit therapy titers treat vaccination Vaccinations vaccine dose Zeneca [DOI] 10.1111/trf.16934 PMC 바로가기 [Article Type] Article
Essential oil nebulization in mild COVID-19(EONCO): Early phase exploratory clinical trialResearch article Published on 2022-07-012022-10-05 Journal: Journal of Ayurveda and Integrative Medicine [Category] 임상, [키워드] Anosmia antiviral action appear approach Asymptomatic benefit carried clearance clinical trial Combination Concentration coronavirus disease COVID-19 doses Efficacy essential oil Eucalyptus oil evaluated Evolution exploratory frequencies Inconclusive Mild multiple ascending dose objective Open-label participant Peppermint oil phase Placebo polymerase chain produced Randomized reached reduced respiratory symptom Result reverse transcription Safety significantly Steroids study participant Symptom symptomatic Symptomatic relief Tea tree oil Therapeutic benefit therapeutic efficacy Toxicity Treatment Viremia with mild disease [DOI] 10.1016/j.jaim.2022.100626 [Article Type] Research article
Molecular modelling identification of phytocompounds from selected African botanicals as promising therapeutics against druggable human host cell targets of SARS-CoV-2SARS-CoV-2의 약물 가능한 인간 숙주 세포 표적에 대한 유망한 치료제로서 선택된 아프리카 식물의 식물 화합물의 분자 모델링 식별Article Published on 2022-07-012022-09-11 Journal: Journal of molecular graphics & modelling [Category] COVID19(2023년), SARS, 치료제, [키워드] active site acute respiratory syndrome coronavirus African Amino acid amino acid residue angiotensin Angiotensin converting enzyme-2 bafilomycin binding binding energy candidate drug cathepsin cathepsin L caused Cell clinical evaluation clinical evaluations Compound compounds Computational methods coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Critical enzyme galactoside hACE2 highly pathogenic host cell Host cell targets human cell human cells human host in vitro inhibitor inhibitors of TMPRSS2 inhibitory inhibitory action investigated kaempferol mechanism MLN-4760 Modification modifications modulate molecular dynamics Molecular dynamics simulation myricetin nafamostat Phytocompounds Protein Proteins Replication Research respiratory Respiratory disease respiratory diseases rutinoside SARS-CoV-2 selected Serine severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Structural analysis subjects subsequent target Therapeutic benefit these compound these compounds TMPRSS2 transmembrane serine protease Verbascoside viral entry viral spike protein viral spike proteins while [DOI] 10.1016/j.jmgm.2022.108185 PMC 바로가기 [Article Type] Article
JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoidsJAK 억제제는 사구체 세포에서 COVID-19 사이토카인 유도 JAK/STAT/APOL1 신호전달 및 인간 신장 오르가노이드에서 족세포병증을 차단합니다Article Published on 2022-06-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), MERS, SARS, 유전자 메커니즘, 진단, [키워드] abundantly expressed alleles APOL1 Baricitinib best block blocked capillary carried carrier cause Cell Cell Biology cells collapse controls COVID-19 COVID-19 infection cytokine Cytokines demonstrated Endothelial cell endothelial cells expression glomerular glomerular capillaries human kidney Infection inhibitor iPS cells. JAK inhibitor jak inhibitors JAK/STAT JAK/STAT pathway JAK/STAT signaling JAK1 kidney Kidney disease knowledge majority mechanism Nephrology nephropathy Organoid organoids pathogenic Patient phenotype podocyte Podocytes Protein reduced rescued resulting risk SARS-CoV-2 Signaling STAT Support Therapeutic benefit therapeutic benefits Trigger viability [DOI] 10.1172/jci.insight.157432 PMC 바로가기 [Article Type] Article
A phase II, double blind, placebo-controlled, randomized evaluation of the safety and efficacy of tafenoquine in patients with mild-moderate COVID-19 diseaseResearch article Published on 2022-04-012022-10-05 Journal: New Microbes and New Infections [Category] 임상, 치료제, [키워드] accelerated Administered administration adverse event Analysis ARMS bpm clinical recovery clinical trial cough COVID-19 COVID-19 disease COVID-19 patients COVID-19 symptom COVID-19 symptoms Day defined disease dose double blind Dyspnea Efficacy evaluated exhibited facilitate FDA-Approved Regimen for Malaria Pophylaxis Fever Hospitalization individual ITT population Mild Moderate COVID-19 occurred Outpatient outpatients Patient per day Placebo placebo-controlled PP population primary endpoint proportion Randomized recorded respiratory rate response Shortness of breath tafenoquine the primary endpoint Therapeutic benefit time Trial [DOI] 10.1016/j.nmni.2022.100986 [Article Type] Research article
Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicityArticle Published on 2022-02-082022-10-04 Journal: Nature Communications [Category] 유전자 메커니즘, [키워드] alcohol antioxidant Apoptosis bone marrow failure Caenorhabditis elegan Cancer metabolism cause cellular cellular damage Chemical genetics coding contributing to crosslinking cytotoxicity DNA DNA damage DNA repair endogenous enzyme formaldehyde functional GSH human cell Mechanisms of disease metabolic pathways metabolite Mutation oxidative stress Patient prevented PROTECT question raising Redox imbalance reduced resulting syndrome Therapeutic benefit thiol group thought Toxicity Trigger underlie yielding [DOI] 10.1038/s41467-022-28242-7 PMC 바로가기 [Article Type] Article
Pharmacokinetic/Pharmacodynamic Considerations of Alternate Dosing Strategies of Tocilizumab in COVID-19COVID-19에서 토실리주맙의 대체 투여 전략의 약동학/약력학적 고려사항Review Published on 2022-02-012022-09-12 Journal: Clinical pharmacokinetics [Category] COVID19(2023년), SARS, 진단, [키워드] analyses appear approval characterized coronavirus disease COVID-19 Critical distribution dose doses Dosing dosing regimen Efficacy evaluated fixed IMPROVE limitation Mortality observation parameter Patient pharmacokinetic REMAP-CAP trial required severe COVID-19 shown single dose Strategy suggested Therapeutic benefit threshold Tocilizumab Treatment Trial trials unlikely US FDA [DOI] 10.1007/s40262-021-01092-0 PMC 바로가기 [Article Type] Review