Current Uses of Bromelain in Children: A Narrative ReviewReview Published on 2024-03-212024-09-05 Journal: Children [Category] update2024, [키워드] Ananas comosus Biomarkers Bromelain children drug response nutraceuticals pineapple therapeutic effects [DOI] 10.3390/children11030377 PMC 바로가기 [Article Type] Review
Current evidence on the use of anakinra in COVID-19Review article Published on 2022-10-012022-10-05 Journal: International immunopharmacology [Category] COVID19(2023년), SARS, 바이오마커, 임상, 진단, 치료제, [키워드] acute respiratory distress syndrome administration Anakinra approval clinical evidence clinical status COVID-19 COVID-19 patient COVID-19 patients current cytokine cytokine release Cytokine release syndrome Cytokine storm dose early stage effective Evidence IL-1 IL-1 receptor antagonist Immunomodulatory agent include inhibit interleukin-1 intravenous knowledge management mechanical ventilation multiple organ failure off-label Prevent progression Remdesivir required secondary hemophagocytic lymphohistiocytosis shown syndrome the disease the SARS-CoV-2 therapeutic effect therapeutic effects therapy Treatment treatment approach viral replication [DOI] 10.1016/j.intimp.2022.109075 [Article Type] Review article
Structural determination of an antibody that specifically recognizes polyethylene glycol with a terminal methoxy group Research Published on 2022-08-012022-10-05 Journal: Communications Chemistry [Category] 변종, [키워드] Analysis antibodies antibody antigenicity bind binding circulation complex cross-reactivity glycol humanized hydrogen bond interaction hydrogen bond interactions hydrophobic hydroxyl groups IMPROVE induce mechanism Neutral offer polar Polymer recognize replacement residue resulting Serine specificity therapeutic effects therapeutic efficacy Therapeutic molecule Van [DOI] 10.1038/s42004-022-00709-0 [Article Type] Research
A SARS-CoV-2 nanobody that can bind to the RBD region may be used for treatment in COVID-19 in animalsRBD 영역에 결합할 수 있는 SARS-CoV-2 나노바디는 동물의 COVID-19 치료에 사용될 수 있습니다Article Published on 2022-07-012022-09-11 Journal: Research in veterinary science [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, 치료법, [키워드] animals binding caused cells coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disease in vitro in vivo infecting Infectious virus microorganism microorganisms nanobodies nanobody neutralizing antibody Prevent pseudovirus pseudoviruses RBD RBD protein respiratory S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 Spike RBD protein Severe acute respiratory syndrome spike the RBD the SARS-CoV-2 therapeutic effects therapeutic potential Treatment treatment of COVID-19 was obtained was used [DOI] 10.1016/j.rvsc.2022.02.003 PMC 바로가기 [Article Type] Article
Application of exosomes for the alleviation of COVID-19-related pathologiesReview Published on 2022-07-012023-07-09 Journal: Cell biochemistry and function [Category] COVID19(2023년), [키워드] COVID-19 Exosomes paracrine interaction regenerative potential stem cell therapeutic effects [DOI] 10.1002/cbf.3720 PMC 바로가기 [Article Type] Review
Induction of high affinity monoclonal antibodies against SARS-CoV-2 variant infection using a DNA prime-protein boost strategyDNA 프라임-단백질 부스트 전략을 이용한 SARS-CoV-2 변이체 감염에 대한 고친화성 단일클론항체 유도Article Published on 2022-06-092022-09-11 Journal: Journal of Biomedical Science [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Alpha alpha and delta variants angiotensin angiotensin-converting enzyme 2 animals Antibody titers approach approved best Beta Beta variant binding ability binding affinity boost broad spectrum clone coronavirus Coverage COVID-19 COVID-19 vaccination D614G Delta delta variant DNA ELISA Emergency use Endemic epitope epitope mapping Epitopes evaluated exhibit flu Gamma generate high affinity Human angiotensin-converting enzyme 2 include induction Infection Lambda monoclonal antibodies monoclonal antibody monoclonal antibody combination Multiple neutralization neutralization potency neutralize Neutralizing antibody titer neutralizing capacity neutralizing epitope neutralizing epitopes Outbreaks PROTECT RBD Receptor-binding domain regions SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant selected Spike protein the receptor-binding domain the spike protein therapeutic drug therapeutic effect therapeutic effects treat treated Treatment variant variants VoC VOCs were used Wuhan strain [DOI] 10.1186/s12929-022-00823-0 PMC 바로가기 [Article Type] Article
Tranilast as an Adjunctive Therapy in Hospitalized Patients with Severe COVID- 19: A Randomized Controlled Trial중증 COVID-19로 입원한 환자의 보조 요법으로서의 트라닐라스트: 무작위 대조 시험Randomized Controlled Trial Published on 2022-06-012022-09-11 Journal: Archives of medical research [Category] COVID19(2023년), SARS, 신약개발, 임상, 치료제, [키워드] 1:1 addition adjuvant therapy Admitted Patient antiviral drug antiviral drugs antiviral therapy assigned Clinical findings clinical trial collected data Combination Comparisons control group control groups Controlled COVID COVID-19 Cytokine storm death effective Efficacy ENhance evaluate expression hospital Hospitalization hospitalized patient ICU IL-1 Inflammation Inflammatory cytokine inhibitor Intervention intervention group Iran Laboratory tests LDH Long NLR NLRP3 NLRP3 inflammasome O2 Saturation open Open-label Patient patients with COVID-19 Randomly Safe SARS-CoV-2 severe COVID-19 significantly lower therapeutic effect therapeutic effects therapy TNF Tranilast Tranilast. was used with COVID-19 [DOI] 10.1016/j.arcmed.2022.03.002 PMC 바로가기 [Article Type] Randomized Controlled Trial
Potential plants for inflammatory dysfunction in the SARS-CoV-2 infectionSARS-CoV-2 감염에서 염증 기능 장애에 대한 잠재적 식물Review Published on 2022-06-012022-09-11 Journal: Inflammopharmacology [Category] COVID19(2023년), SARS, 치료기술, [키워드] Anti-inflammatory anti-inflammatory effect Anti-inflammatory effects antioxidant appear cardiovascular risk characterized clinical trial clinical trials CRP Cytokines described disease dysfunction Effects Efficacy evaluate form homeostasis IFN-γ IL-1 IL-6 Infection Inflammation Inflammatory Inflammatory cytokines Inflammatory marker inflammatory markers inflammatory process marker mechanism modulation organism oxidative plant plants Potential pro-inflammatory cytokine responsible SARS-CoV-2 SARS-COV-2 infection selected significantly increased systematic review the SARS-CoV-2 therapeutic effects TNF-a [DOI] 10.1007/s10787-022-00981-5 PMC 바로가기 [Article Type] Review
Cancer patient survival can be parametrized to improve trial precision and reveal time-dependent therapeutic effectsArticle Published on 2022-02-152022-10-04 Journal: Nature Communications [Category] 신약개발, 임상, [키워드] Analysis Arm assumption Cancer clinical outcomes clinical trial Cox proportional hazard deviation early phase events Factor form function generate Immune checkpoint inhibitors IMPROVE increase individual Interpretation likelihood oncology patient survival phase Precision Randomized controlled trials representing significantly statistical analysis Statistical methods Support survival survival curve therapeutic effect therapeutic effects Trial Weibull distribution [DOI] 10.1038/s41467-022-28410-9 PMC 바로가기 [Article Type] Article
Efficacy and safety of three new oral antiviral treatment (molnupiravir, fluvoxamine and Paxlovid) for COVID-19:a meta-analysisCovid-19에 대한 3 가지 새로운 경구 항 바이러스 처리 (Molnupiravir, Fluvoxamine 및 Paxlovid)의 효능 및 안전성 : 메타 분석Meta-Analysis Published on 2022-02-042022-09-10 Journal: Annals of Medicine [Category] COVID19(2023년), Fulltext, SARS, 치료제, [키워드] (molnupiravir 95% confidence interval addition adverse event adverse events Antiviral antiviral drug antiviral drugs Antiviral treatment antivirals article available data Cochrane Library conducted control group coronavirus coronavirus disease COVID-19 COVID-19 patient COVID-19 patients COVID-19 research died drug effective eight Epidemic evaluate exhibiting fluvoxamine Guidance Hospitalization Hospitalized Meta-analysis molnupiravir Mortality Occurrence Odds ratio Patient patients with COVID-19 Paxlovid Paxlovid™ placebo group reduced reducing Result retrieved screened searched shown therapeutic effect therapeutic effects treatment for COVID-19 Web of Science [DOI] 10.1080/07853890.2022.2034936 PMC 바로가기 [Article Type] Meta-Analysis