Circular RNAs in and out of Cells: Therapeutic Usages of Circular RNAsMinireview Published on 2023-01-312024-09-05 Journal: Molecules and cells [Category] update2024, [키워드] Biomarkers circular RNAs therapeutic molecules therapeutic targets [DOI] 10.14348/molcells.2023.2170 PMC 바로가기 [Article Type] Minireview
In silico investigation and potential therapeutic approaches of natural products for COVID-19: Computer-aided drug design perspectiveArticle Published on 2022-08-222022-11-16 Journal: Frontiers in Cellular and Infection Microbiology [Category] SARS, 신약개발, [키워드] absence acute respiratory syndrome alkaloids analyzed anti-SARS-CoV-2 approach approved assist binding binding energy caused Clinicians Compound computer-aided drug design contribute coronavirus COVID-19 death derivative determine Diseases drug candidate drug design Drug discovery drugs effective facilitate highest in silico Ligand mechanism Medicines natural natural products Perspective pharmacological physician phytochemical Practitioner public health RdRP reported Research researcher researchers RNA polymerase Safe SARS-CoV-2 SARS-CoV-2 main protease subsequent therapeutic Therapeutic approach therapeutic molecules therapeutic target took place Toxicity Treatment vaccination viral replication Virtual screening [DOI] 10.3389/fcimb.2022.929430 PMC 바로가기
Identification of differentially expressed genes and their major pathways among the patient with COVID-19, cystic fibrosis, and chronic kidney diseaseResearch article Published on 2022-08-072022-10-05 Journal: Informatics in Medicine Unlocked [Category] 바이오마커, 변종, [키워드] analysed Analysis bioinformatics cause Chronic kidney disease CKD Comorbidity COVID-19 COVID-19 disease cystic fibrosis dataset differentially expressed gene Differentially expressed genes disease disease categories drug expression profiling fibrosis FOXN2 functional Gene regulatory networks help HNF4A identification identify indicated Infectious disease Interaction involved majority MicroRNAs Mild moderate Multiple Ontology pathophysiological pathway Patient patients with COVID-19 performed Potential biomarker predicted protein-protein interaction PRPF31 reducing regulated researcher respiratory symptoms RIOK3 SARS-CoV-2 SARS-CoV-2 virus System biology the patient therapeutic molecules transcription factor Transcriptomic profiling UBC upregulated upregulated genes virus was done with COVID-19 [DOI] 10.1016/j.imu.2022.101038 [Article Type] Research article
A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo이중특이성 단량체 나노바디는 스파이크 삼량체 이량체를 유도하고 생체 내에서 SARS-CoV-2를 중화합니다Article Published on 2022-01-102022-09-10 Journal: Nature Communications [Category] SARS, 변종, 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibodies binding Antiviral Beta Beta variant binding coronavirus cross-neutralize Delta variants elicited host cell host cell receptor human ACE2 in vivo inactivation induce inhibit interact Isolation mechanisms mice monomeric nanobody neutralization neutralize RBD RBDs respiratory SARS-CoV SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus spike trimer therapeutic Therapeutic molecule therapeutic molecules therapeutic potential Transgenic mouse Trimers variant variants variants of concern Viral Viral antigen viral antigens viral infection virus [DOI] 10.1038/s41467-021-27610-z PMC 바로가기 [Article Type] Article
Sensitive visualization of SARS-CoV-2 RNA with CoronaFISHCoronaFISH를 사용한 SARS-CoV-2 RNA의 민감한 시각화Research Article Published on 2022-01-072022-09-10 Journal: Life Science Alliance [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adaptation African green monkey caused cell lines complement coronavirus COVID-19 COVID-19 pandemic Critical diagnostics Drug screening electron microscopy green monkey human cell lines infected cell infected cells Infection initial linear lung tissue Microscopy nasal swabs oligonucleotide sequences pathophysiology Patient positive positive-sense single-stranded RNA probe probes protocol Replication required Research respiratory RNA RNA virus SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 RNA Screen sensitive severe acute respiratory syndrome Coronavirus source code synthesis Template therapeutic molecules tissue Transcription Viral viral replication Viral RNA virus vRNA [DOI] 10.26508/lsa.202101124 PMC 바로가기 [Article Type] Research Article
Construction of the Enterococcal Strain Expressing Immunogenic Fragment of SARS-Cov-2 VirusPharmacology Published on 2022-01-052022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] Antigen Bacteria construction demonstrated DNA fragment DNA sequencing domain Enterococcus experiment expression fragment of Frame Genome Gut health care systems human sera IgA response IgG response immune electron microscopy immune response Immunity immunoprecipitation Infection knowledge memory mucosal mucous membrane nasal Oral vaccine pandemic pathogen Patient Probiotic probiotic-based vaccines Protein RNA S protein SARS-CoV-2 strain T-cell therapeutic molecules Transcription vaccination Vaccine vaccine candidate [DOI] 10.3389/fphar.2021.807256 PMC 바로가기 [Article Type] Pharmacology
Molecular modelling studies unveil potential binding sites on human serum albumin for selected experimental and in silico COVID-19 drug candidate moleculesResearch article Published on 2022-01-012022-10-05 Journal: Saudi Journal of Biological Sciences [Category] 신약개발, 치료제, [키워드] analyzed approach Arbidol bind binding binding energy binding free energy binding site blood plasma calculated Carmofur complexes Compound compounds coronavirus disease COVID-19 daclatasvir demonstrated dihydroergotamine disulfiram drug drug candidate Effects evaluate geometric HAS Human Human serum albumin Hydrogen bond hydrophobic interactions identify in silico inhibitor interacting residue mechanism MM/PBSA moderate molecular molecular docking Molecular dynamics simulation molecular interaction Molecular mechanics P-glycoprotein P450 paritaprevir permeation Pharmacodynamics pharmacokinetic pharmacokinetics pharmacological prevalent Protein saquinavir selected serum albumin Serum protein stability therapeutic therapeutic molecules were used [DOI] 10.1016/j.sjbs.2021.09.042 [Article Type] Research article
Therapeutic development by repurposing drugs targeting SARS-CoV-2 spike protein interactions by simulation studiesResearch article Published on 2021-08-012022-10-05 Journal: Saudi Journal of Biological Sciences [Category] 신약개발, [키워드] affected Analysis antiviral drugs binding energy conducted Corona COVID-19 COVID-19 disease deviation docking Doxorubicin drug drugs drugs targeting evaluate Exemestane fluctuation Gatifloxacin gyration host cell Hydrogen bond in silico inhibit Interaction Interpretation MDs molecular interaction Molecular simulation pandemic pathogenic Prevent radius RBD complex reference Research respiratory Respiratory illness RMSD RMSF root SARS-CoV-2 SARS-CoV-2 spike protein Simulation study Spike protein Spread square suggested the SARS-CoV-2 therapeutic molecules transmitted virus spike protein Wuhan, China [DOI] 10.1016/j.sjbs.2021.04.057 [Article Type] Research article
An Updated Review of Computer-Aided Drug Design and Its Application to COVID-19Review Published on 2021-06-242022-10-27 Journal: BioMed Research International [Category] [키워드] accelerated acute respiratory syndrome application approved drug category clinicians and researcher computer-aided drug design coronavirus coronavirus disease COVID-19 drug drug candidate drug design Drug discovery drug target fatal disease Health help helping highlight implicated include involved lack management molecular molecular docking outbreak pandemic Pathogenesis pharmacological Quantitative researcher review SARS-CoV-2 therapeutic molecules Vaccine [DOI] 10.1155/2021/8853056 PMC 바로가기 [Article Type] Review
An Updated Review of Computer-Aided Drug Design and Its Application to COVID-19Review Published on 2021-06-242022-10-27 Journal: BioMed Research International [Category] COVID-19, SARS, [키워드] accelerated acute respiratory syndrome application approved drug category clinicians and researcher computer-aided drug design coronavirus coronavirus disease COVID-19 drug drug candidate drug design Drug discovery drug target fatal disease Health help helping highlight implicated include involved lack management molecular molecular docking outbreak pandemic Pathogenesis pharmacological Quantitative researcher review SARS-CoV-2 therapeutic molecules Vaccine [DOI] 10.1155/2021/8853056 PMC 바로가기 [Article Type] Review